Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy

As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests...

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Autores principales:	Aditya Bhalerao, Snehal Raut, Behnam Noorani, Salvatore Mancuso, Luca Cucullo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 COVID-19 stem cells mesenchymal therapeutics regenerative Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/95ec41c5284d4e9c98b2bd05700c4b69
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spelling	oai:doaj.org-article:95ec41c5284d4e9c98b2bd05700c4b692021-11-25T17:08:27ZMolecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy10.3390/cells101128782073-4409https://doaj.org/article/95ec41c5284d4e9c98b2bd05700c4b692021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2878https://doaj.org/toc/2073-4409As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests itself in the form of severe respiratory distress, it is also known to cause systemic damage to almost all major organs and organ systems within the body. In this review, we discuss the molecular mechanisms leading to multi-organ failure seen in COVID-19 patients. We also examine the potential of stem cell therapy in treating COVID-19 multi-organ failure cases.Aditya BhaleraoSnehal RautBehnam NooraniSalvatore MancusoLuca CuculloMDPI AGarticleSARS-CoV-2COVID-19stem cellsmesenchymaltherapeuticsregenerativeBiology (General)QH301-705.5ENCells, Vol 10, Iss 2878, p 2878 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 stem cells mesenchymal therapeutics regenerative Biology (General) QH301-705.5
spellingShingle	SARS-CoV-2 COVID-19 stem cells mesenchymal therapeutics regenerative Biology (General) QH301-705.5 Aditya Bhalerao Snehal Raut Behnam Noorani Salvatore Mancuso Luca Cucullo Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
description	As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests itself in the form of severe respiratory distress, it is also known to cause systemic damage to almost all major organs and organ systems within the body. In this review, we discuss the molecular mechanisms leading to multi-organ failure seen in COVID-19 patients. We also examine the potential of stem cell therapy in treating COVID-19 multi-organ failure cases.
format	article
author	Aditya Bhalerao Snehal Raut Behnam Noorani Salvatore Mancuso Luca Cucullo
author_facet	Aditya Bhalerao Snehal Raut Behnam Noorani Salvatore Mancuso Luca Cucullo
author_sort	Aditya Bhalerao
title	Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
title_short	Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
title_full	Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
title_fullStr	Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
title_full_unstemmed	Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
title_sort	molecular mechanisms of multi-organ failure in covid-19 and potential of stem cell therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/95ec41c5284d4e9c98b2bd05700c4b69
work_keys_str_mv	AT adityabhalerao molecularmechanismsofmultiorganfailureincovid19andpotentialofstemcelltherapy AT snehalraut molecularmechanismsofmultiorganfailureincovid19andpotentialofstemcelltherapy AT behnamnoorani molecularmechanismsofmultiorganfailureincovid19andpotentialofstemcelltherapy AT salvatoremancuso molecularmechanismsofmultiorganfailureincovid19andpotentialofstemcelltherapy AT lucacucullo molecularmechanismsofmultiorganfailureincovid19andpotentialofstemcelltherapy
_version_	1718412727467114496

Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy

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