Reduced mitochondrial respiration in T cells of patients with major depressive disorder

Summary: Converging evidence indicates that major depressive disorder (MDD) and metabolic disorders might be mediated by shared (patho)biological pathways. However, the converging cellular and molecular signatures remain unknown. Here, we investigated metabolic dysfunction on a systemic, cellular, a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Stefanie Gamradt, Helge Hasselmann, Aline Taenzer, Jelena Brasanac, Victoria Stiglbauer, Arne Sattler, Max Sajitz-Hermstein, Sylwia Kierszniowska, Caren Ramien, Jan Nowacki, Lea Mascarell-Maricic, Katja Wingenfeld, Dominique Piber, Andreas Ströhle, Katja Kotsch, Friedemann Paul, Christian Otte, Stefan M. Gold
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cellular neuroscience Immunology Metabolomics Science Q
Acceso en línea:	https://doaj.org/article/95ed7e57e8464bdcaee0486faec91eaa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:95ed7e57e8464bdcaee0486faec91eaa
record_format	dspace
spelling	oai:doaj.org-article:95ed7e57e8464bdcaee0486faec91eaa2021-11-20T05:09:49ZReduced mitochondrial respiration in T cells of patients with major depressive disorder2589-004210.1016/j.isci.2021.103312https://doaj.org/article/95ed7e57e8464bdcaee0486faec91eaa2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012815https://doaj.org/toc/2589-0042Summary: Converging evidence indicates that major depressive disorder (MDD) and metabolic disorders might be mediated by shared (patho)biological pathways. However, the converging cellular and molecular signatures remain unknown. Here, we investigated metabolic dysfunction on a systemic, cellular, and molecular level in unmedicated patients with MDD compared with matched healthy controls (HC). Despite comparable BMI scores and absence of cardiometabolic disease, patients with MDD presented with significant dyslipidemia. On a cellular level, T cells obtained from patients with MDD exhibited reduced respiratory and glycolytic capacity. Gene expression analysis revealed increased carnitine palmitoyltransferase IA (CPT1a) levels in T cells, the rate-limiting enzyme for mitochondrial long-chain fatty acid oxidation. Together, our results indicate metabolic dysfunction in unmedicated, non-overweight patients with MDD on a systemic, cellular, and molecular level. This evidence for reduced mitochondrial respiration in T cells of patients with MDD provides translation of previous animal studies regarding a putative role of altered immunometabolism in depression pathobiology.Stefanie GamradtHelge HasselmannAline TaenzerJelena BrasanacVictoria StiglbauerArne SattlerMax Sajitz-HermsteinSylwia KierszniowskaCaren RamienJan NowackiLea Mascarell-MaricicKatja WingenfeldDominique PiberAndreas StröhleKatja KotschFriedemann PaulChristian OtteStefan M. GoldElsevierarticleCellular neuroscienceImmunologyMetabolomicsScienceQENiScience, Vol 24, Iss 11, Pp 103312- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cellular neuroscience Immunology Metabolomics Science Q
spellingShingle	Cellular neuroscience Immunology Metabolomics Science Q Stefanie Gamradt Helge Hasselmann Aline Taenzer Jelena Brasanac Victoria Stiglbauer Arne Sattler Max Sajitz-Hermstein Sylwia Kierszniowska Caren Ramien Jan Nowacki Lea Mascarell-Maricic Katja Wingenfeld Dominique Piber Andreas Ströhle Katja Kotsch Friedemann Paul Christian Otte Stefan M. Gold Reduced mitochondrial respiration in T cells of patients with major depressive disorder
description	Summary: Converging evidence indicates that major depressive disorder (MDD) and metabolic disorders might be mediated by shared (patho)biological pathways. However, the converging cellular and molecular signatures remain unknown. Here, we investigated metabolic dysfunction on a systemic, cellular, and molecular level in unmedicated patients with MDD compared with matched healthy controls (HC). Despite comparable BMI scores and absence of cardiometabolic disease, patients with MDD presented with significant dyslipidemia. On a cellular level, T cells obtained from patients with MDD exhibited reduced respiratory and glycolytic capacity. Gene expression analysis revealed increased carnitine palmitoyltransferase IA (CPT1a) levels in T cells, the rate-limiting enzyme for mitochondrial long-chain fatty acid oxidation. Together, our results indicate metabolic dysfunction in unmedicated, non-overweight patients with MDD on a systemic, cellular, and molecular level. This evidence for reduced mitochondrial respiration in T cells of patients with MDD provides translation of previous animal studies regarding a putative role of altered immunometabolism in depression pathobiology.
format	article
author	Stefanie Gamradt Helge Hasselmann Aline Taenzer Jelena Brasanac Victoria Stiglbauer Arne Sattler Max Sajitz-Hermstein Sylwia Kierszniowska Caren Ramien Jan Nowacki Lea Mascarell-Maricic Katja Wingenfeld Dominique Piber Andreas Ströhle Katja Kotsch Friedemann Paul Christian Otte Stefan M. Gold
author_facet	Stefanie Gamradt Helge Hasselmann Aline Taenzer Jelena Brasanac Victoria Stiglbauer Arne Sattler Max Sajitz-Hermstein Sylwia Kierszniowska Caren Ramien Jan Nowacki Lea Mascarell-Maricic Katja Wingenfeld Dominique Piber Andreas Ströhle Katja Kotsch Friedemann Paul Christian Otte Stefan M. Gold
author_sort	Stefanie Gamradt
title	Reduced mitochondrial respiration in T cells of patients with major depressive disorder
title_short	Reduced mitochondrial respiration in T cells of patients with major depressive disorder
title_full	Reduced mitochondrial respiration in T cells of patients with major depressive disorder
title_fullStr	Reduced mitochondrial respiration in T cells of patients with major depressive disorder
title_full_unstemmed	Reduced mitochondrial respiration in T cells of patients with major depressive disorder
title_sort	reduced mitochondrial respiration in t cells of patients with major depressive disorder
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/95ed7e57e8464bdcaee0486faec91eaa
work_keys_str_mv	AT stefaniegamradt reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT helgehasselmann reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT alinetaenzer reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT jelenabrasanac reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT victoriastiglbauer reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT arnesattler reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT maxsajitzhermstein reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT sylwiakierszniowska reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT carenramien reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT jannowacki reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT leamascarellmaricic reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT katjawingenfeld reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT dominiquepiber reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT andreasstrohle reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT katjakotsch reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT friedemannpaul reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT christianotte reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder AT stefanmgold reducedmitochondrialrespirationintcellsofpatientswithmajordepressivedisorder
_version_	1718419556137959424

Reduced mitochondrial respiration in T cells of patients with major depressive disorder

Ejemplares similares