Epidemiological and clinical characteristics of children with human parainfluenza virus associated acute respiratory infection in a general hospital in Sri Lanka

Background: Human parainfluenza viruses (HPIVs) are one of the leading cause of Acute Respiratory Infection (ARI) in children. The prevalence and clinical presentation of HPIV infection in Sri Lankan children is not studied well, therefore the objective of this study was to identify the prevalence a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	RAM Rafeek, MVM Divarathna, AJ Morel, F Noordeen
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Acute respiratory infections Human parainfluenza viruses Epidemiology Children Sri Lanka Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/95ed95728b80475d83a4b332b1a7cd5e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:95ed95728b80475d83a4b332b1a7cd5e
record_format	dspace
spelling	oai:doaj.org-article:95ed95728b80475d83a4b332b1a7cd5e2021-11-04T04:44:05ZEpidemiological and clinical characteristics of children with human parainfluenza virus associated acute respiratory infection in a general hospital in Sri Lanka2667-038010.1016/j.jcvp.2021.100049https://doaj.org/article/95ed95728b80475d83a4b332b1a7cd5e2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667038021000417https://doaj.org/toc/2667-0380Background: Human parainfluenza viruses (HPIVs) are one of the leading cause of Acute Respiratory Infection (ARI) in children. The prevalence and clinical presentation of HPIV infection in Sri Lankan children is not studied well, therefore the objective of this study was to identify the prevalence and clinical features of HPIV infections in children with ARI in General Hospital, Kegalle, Sri Lanka. Methods: Nasopharyngeal aspirate samples (NPA) were collected from hospitalized children with ≤4 days history of ARIs and were tested for HPIV-1, HIPV-2 and HIPV-3 using Direct immunofluorescence assay (DFA). Results: HPIV was detected in 9.4% (47/500) of the children with ARIs. Of this 5 (0.1%) children had HPIV-1 infection, 8 (1.6%) had HPIV-2 infection and 34 (6.8%) had HPIV-3 infection with a male to female ratio of 1.13: 1. Children infected with HPIV-1 and HPIV-3 had moderate bronchiolitis whereas HPIV-2, had mild bronchiolitis. Of the 34 HPIV-3 infected children, 11 had co-infection with human respiratory syncytial virus (HRSV) and 2 had co-infection with influenza A and B, respectively. Two children had co-infection with HPIV-1 and HPIV-2. HPIV-3 circulated throughout the year, however, HPIV-2 circulated only in February and March 2017 in the study area during the study. Conclusion: HPIV infections led to a wide range of symptoms in children and are prevalent throughout the year in the study area. HPIV-3 was the most prevalent HPIV type in the study sample and were associated with mild to moderate ARI in children less than 5 years of age.RAM RafeekMVM DivarathnaAJ MorelF NoordeenElsevierarticleAcute respiratory infectionsHuman parainfluenza virusesEpidemiologyChildrenSri LankaInfectious and parasitic diseasesRC109-216ENJournal of Clinical Virology Plus, Vol 1, Iss 4, Pp 100049- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acute respiratory infections Human parainfluenza viruses Epidemiology Children Sri Lanka Infectious and parasitic diseases RC109-216
spellingShingle	Acute respiratory infections Human parainfluenza viruses Epidemiology Children Sri Lanka Infectious and parasitic diseases RC109-216 RAM Rafeek MVM Divarathna AJ Morel F Noordeen Epidemiological and clinical characteristics of children with human parainfluenza virus associated acute respiratory infection in a general hospital in Sri Lanka
description	Background: Human parainfluenza viruses (HPIVs) are one of the leading cause of Acute Respiratory Infection (ARI) in children. The prevalence and clinical presentation of HPIV infection in Sri Lankan children is not studied well, therefore the objective of this study was to identify the prevalence and clinical features of HPIV infections in children with ARI in General Hospital, Kegalle, Sri Lanka. Methods: Nasopharyngeal aspirate samples (NPA) were collected from hospitalized children with ≤4 days history of ARIs and were tested for HPIV-1, HIPV-2 and HIPV-3 using Direct immunofluorescence assay (DFA). Results: HPIV was detected in 9.4% (47/500) of the children with ARIs. Of this 5 (0.1%) children had HPIV-1 infection, 8 (1.6%) had HPIV-2 infection and 34 (6.8%) had HPIV-3 infection with a male to female ratio of 1.13: 1. Children infected with HPIV-1 and HPIV-3 had moderate bronchiolitis whereas HPIV-2, had mild bronchiolitis. Of the 34 HPIV-3 infected children, 11 had co-infection with human respiratory syncytial virus (HRSV) and 2 had co-infection with influenza A and B, respectively. Two children had co-infection with HPIV-1 and HPIV-2. HPIV-3 circulated throughout the year, however, HPIV-2 circulated only in February and March 2017 in the study area during the study. Conclusion: HPIV infections led to a wide range of symptoms in children and are prevalent throughout the year in the study area. HPIV-3 was the most prevalent HPIV type in the study sample and were associated with mild to moderate ARI in children less than 5 years of age.
format	article
author	RAM Rafeek MVM Divarathna AJ Morel F Noordeen
author_facet	RAM Rafeek MVM Divarathna AJ Morel F Noordeen
author_sort	RAM Rafeek
title	Epidemiological and clinical characteristics of children with human parainfluenza virus associated acute respiratory infection in a general hospital in Sri Lanka
title_short	Epidemiological and clinical characteristics of children with human parainfluenza virus associated acute respiratory infection in a general hospital in Sri Lanka
title_full	Epidemiological and clinical characteristics of children with human parainfluenza virus associated acute respiratory infection in a general hospital in Sri Lanka
title_fullStr	Epidemiological and clinical characteristics of children with human parainfluenza virus associated acute respiratory infection in a general hospital in Sri Lanka
title_full_unstemmed	Epidemiological and clinical characteristics of children with human parainfluenza virus associated acute respiratory infection in a general hospital in Sri Lanka
title_sort	epidemiological and clinical characteristics of children with human parainfluenza virus associated acute respiratory infection in a general hospital in sri lanka
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/95ed95728b80475d83a4b332b1a7cd5e
work_keys_str_mv	AT ramrafeek epidemiologicalandclinicalcharacteristicsofchildrenwithhumanparainfluenzavirusassociatedacuterespiratoryinfectioninageneralhospitalinsrilanka AT mvmdivarathna epidemiologicalandclinicalcharacteristicsofchildrenwithhumanparainfluenzavirusassociatedacuterespiratoryinfectioninageneralhospitalinsrilanka AT ajmorel epidemiologicalandclinicalcharacteristicsofchildrenwithhumanparainfluenzavirusassociatedacuterespiratoryinfectioninageneralhospitalinsrilanka AT fnoordeen epidemiologicalandclinicalcharacteristicsofchildrenwithhumanparainfluenzavirusassociatedacuterespiratoryinfectioninageneralhospitalinsrilanka
_version_	1718445226954063872

Epidemiological and clinical characteristics of children with human parainfluenza virus associated acute respiratory infection in a general hospital in Sri Lanka

Ejemplares similares