Variant-specific inflation factors for assessing population stratification at the phenotypic variance level

Pooling participant-level genetic data into a single analysis can result in variance stratification, reducing statistical performance. Here, the authors develop variant-specific inflation factors to assess variance stratification and apply this to pooled individual-level data from whole genome seque...

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Autores principales:	Tamar Sofer, Xiuwen Zheng, Cecelia A. Laurie, Stephanie M. Gogarten, Jennifer A. Brody, Matthew P. Conomos, Joshua C. Bis, Timothy A. Thornton, Adam Szpiro, Jeffrey R. O’Connell, Ethan M. Lange, Yan Gao, L. Adrienne Cupples, Bruce M. Psaty, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Kenneth M. Rice
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95ef2a1716c643edaaee931435315164
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spelling	oai:doaj.org-article:95ef2a1716c643edaaee9314353151642021-12-02T18:06:24ZVariant-specific inflation factors for assessing population stratification at the phenotypic variance level10.1038/s41467-021-23655-22041-1723https://doaj.org/article/95ef2a1716c643edaaee9314353151642021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23655-2https://doaj.org/toc/2041-1723Pooling participant-level genetic data into a single analysis can result in variance stratification, reducing statistical performance. Here, the authors develop variant-specific inflation factors to assess variance stratification and apply this to pooled individual-level data from whole genome sequencing.Tamar SoferXiuwen ZhengCecelia A. LaurieStephanie M. GogartenJennifer A. BrodyMatthew P. ConomosJoshua C. BisTimothy A. ThorntonAdam SzpiroJeffrey R. O’ConnellEthan M. LangeYan GaoL. Adrienne CupplesBruce M. PsatyNHLBI Trans-Omics for Precision Medicine (TOPMed) ConsortiumKenneth M. RiceNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tamar Sofer Xiuwen Zheng Cecelia A. Laurie Stephanie M. Gogarten Jennifer A. Brody Matthew P. Conomos Joshua C. Bis Timothy A. Thornton Adam Szpiro Jeffrey R. O’Connell Ethan M. Lange Yan Gao L. Adrienne Cupples Bruce M. Psaty NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Kenneth M. Rice Variant-specific inflation factors for assessing population stratification at the phenotypic variance level
description	Pooling participant-level genetic data into a single analysis can result in variance stratification, reducing statistical performance. Here, the authors develop variant-specific inflation factors to assess variance stratification and apply this to pooled individual-level data from whole genome sequencing.
format	article
author	Tamar Sofer Xiuwen Zheng Cecelia A. Laurie Stephanie M. Gogarten Jennifer A. Brody Matthew P. Conomos Joshua C. Bis Timothy A. Thornton Adam Szpiro Jeffrey R. O’Connell Ethan M. Lange Yan Gao L. Adrienne Cupples Bruce M. Psaty NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Kenneth M. Rice
author_facet	Tamar Sofer Xiuwen Zheng Cecelia A. Laurie Stephanie M. Gogarten Jennifer A. Brody Matthew P. Conomos Joshua C. Bis Timothy A. Thornton Adam Szpiro Jeffrey R. O’Connell Ethan M. Lange Yan Gao L. Adrienne Cupples Bruce M. Psaty NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Kenneth M. Rice
author_sort	Tamar Sofer
title	Variant-specific inflation factors for assessing population stratification at the phenotypic variance level
title_short	Variant-specific inflation factors for assessing population stratification at the phenotypic variance level
title_full	Variant-specific inflation factors for assessing population stratification at the phenotypic variance level
title_fullStr	Variant-specific inflation factors for assessing population stratification at the phenotypic variance level
title_full_unstemmed	Variant-specific inflation factors for assessing population stratification at the phenotypic variance level
title_sort	variant-specific inflation factors for assessing population stratification at the phenotypic variance level
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/95ef2a1716c643edaaee931435315164
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Variant-specific inflation factors for assessing population stratification at the phenotypic variance level

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