Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

Inhibitory interneuron subtypes differentially control place cell representations in CA1. Here, the authors show that parvalbumin and somatostatin interneuron synapses onto CA1 pyramidal neurons exhibit distinct plasticity mechanisms and incorporating this insight into circuit-level modeling leads t...

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Autores principales:	Matt Udakis, Victor Pedrosa, Sophie E. L. Chamberlain, Claudia Clopath, Jack R. Mellor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95ef49a5a5cf4af0b8a71422dec6512e
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spelling	oai:doaj.org-article:95ef49a5a5cf4af0b8a71422dec6512e2021-12-02T19:10:37ZInterneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output10.1038/s41467-020-18074-82041-1723https://doaj.org/article/95ef49a5a5cf4af0b8a71422dec6512e2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18074-8https://doaj.org/toc/2041-1723Inhibitory interneuron subtypes differentially control place cell representations in CA1. Here, the authors show that parvalbumin and somatostatin interneuron synapses onto CA1 pyramidal neurons exhibit distinct plasticity mechanisms and incorporating this insight into circuit-level modeling leads to stable place cell representations.Matt UdakisVictor PedrosaSophie E. L. ChamberlainClaudia ClopathJack R. MellorNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matt Udakis Victor Pedrosa Sophie E. L. Chamberlain Claudia Clopath Jack R. Mellor Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
description	Inhibitory interneuron subtypes differentially control place cell representations in CA1. Here, the authors show that parvalbumin and somatostatin interneuron synapses onto CA1 pyramidal neurons exhibit distinct plasticity mechanisms and incorporating this insight into circuit-level modeling leads to stable place cell representations.
format	article
author	Matt Udakis Victor Pedrosa Sophie E. L. Chamberlain Claudia Clopath Jack R. Mellor
author_facet	Matt Udakis Victor Pedrosa Sophie E. L. Chamberlain Claudia Clopath Jack R. Mellor
author_sort	Matt Udakis
title	Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
title_short	Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
title_full	Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
title_fullStr	Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
title_full_unstemmed	Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
title_sort	interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto ca1 pyramidal neurons shapes hippocampal output
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/95ef49a5a5cf4af0b8a71422dec6512e
work_keys_str_mv	AT mattudakis interneuronspecificplasticityatparvalbuminandsomatostatininhibitorysynapsesontoca1pyramidalneuronsshapeshippocampaloutput AT victorpedrosa interneuronspecificplasticityatparvalbuminandsomatostatininhibitorysynapsesontoca1pyramidalneuronsshapeshippocampaloutput AT sophieelchamberlain interneuronspecificplasticityatparvalbuminandsomatostatininhibitorysynapsesontoca1pyramidalneuronsshapeshippocampaloutput AT claudiaclopath interneuronspecificplasticityatparvalbuminandsomatostatininhibitorysynapsesontoca1pyramidalneuronsshapeshippocampaloutput AT jackrmellor interneuronspecificplasticityatparvalbuminandsomatostatininhibitorysynapsesontoca1pyramidalneuronsshapeshippocampaloutput
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Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

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