HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways

Human cytomegalovirus (HCMV) has evolved several mechanisms to evade the host immune response. Here, Park et al. show that HCMV-encoded US7 and US8 proteins bind TLR3 and TLR4 and facilitate TLR degradation by distinct mechanisms, including ER-associated and lysosomal degradation.

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Autores principales:	Areum Park, Eun A. Ra, Taeyun A. Lee, Hyun jin Choi, Eunhye Lee, Sujin Kang, Jun-Young Seo, Sungwook Lee, Boyoun Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95f0e0a3d5bc417b873a6782f779185b
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spelling	oai:doaj.org-article:95f0e0a3d5bc417b873a6782f779185b2021-12-02T15:36:23ZHCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways10.1038/s41467-019-12641-42041-1723https://doaj.org/article/95f0e0a3d5bc417b873a6782f779185b2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12641-4https://doaj.org/toc/2041-1723Human cytomegalovirus (HCMV) has evolved several mechanisms to evade the host immune response. Here, Park et al. show that HCMV-encoded US7 and US8 proteins bind TLR3 and TLR4 and facilitate TLR degradation by distinct mechanisms, including ER-associated and lysosomal degradation.Areum ParkEun A. RaTaeyun A. LeeHyun jin ChoiEunhye LeeSujin KangJun-Young SeoSungwook LeeBoyoun ParkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Areum Park Eun A. Ra Taeyun A. Lee Hyun jin Choi Eunhye Lee Sujin Kang Jun-Young Seo Sungwook Lee Boyoun Park HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways
description	Human cytomegalovirus (HCMV) has evolved several mechanisms to evade the host immune response. Here, Park et al. show that HCMV-encoded US7 and US8 proteins bind TLR3 and TLR4 and facilitate TLR degradation by distinct mechanisms, including ER-associated and lysosomal degradation.
format	article
author	Areum Park Eun A. Ra Taeyun A. Lee Hyun jin Choi Eunhye Lee Sujin Kang Jun-Young Seo Sungwook Lee Boyoun Park
author_facet	Areum Park Eun A. Ra Taeyun A. Lee Hyun jin Choi Eunhye Lee Sujin Kang Jun-Young Seo Sungwook Lee Boyoun Park
author_sort	Areum Park
title	HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways
title_short	HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways
title_full	HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways
title_fullStr	HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways
title_full_unstemmed	HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways
title_sort	hcmv-encoded us7 and us8 act as antagonists of innate immunity by distinctively targeting tlr-signaling pathways
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/95f0e0a3d5bc417b873a6782f779185b
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HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways

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