Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma

Melanoma: Tumor differences within a patient may explain heterogeneous responses Patients with metastatic melanoma display molecular and immune differences across tumor sites associated with differential drug responses. A team led by Jennifer Wargo from the University of Texas MD Anderson Cancer Cen...

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Autores principales:	Alexandre Reuben, Christine N. Spencer, Peter A. Prieto, Vancheswaran Gopalakrishnan, Sangeetha M. Reddy, John P. Miller, Xizeng Mao, Mariana Petaccia De Macedo, Jiong Chen, Xingzhi Song, Hong Jiang, Pei-Ling Chen, Hannah C. Beird, Haven R. Garber, Whijae Roh, Khalida Wani, Eveline Chen, Cara Haymaker, Marie-Andrée Forget, Latasha D. Little, Curtis Gumbs, Rebecca L. Thornton, Courtney W. Hudgens, Wei-Shen Chen, Jacob Austin-Breneman, Robert Szczepaniak Sloane, Luigi Nezi, Alexandria P. Cogdill, Chantale Bernatchez, Jason Roszik, Patrick Hwu, Scott E. Woodman, Lynda Chin, Hussein Tawbi, Michael A. Davies, Jeffrey E. Gershenwald, Rodabe N. Amaria, Isabella C. Glitza, Adi Diab, Sapna P. Patel, Jianhua Hu, Jeffrey E. Lee, Elizabeth A. Grimm, Michael T. Tetzlaff, Alexander J. Lazar, Ignacio I. Wistuba, Karen Clise-Dwyer, Brett W. Carter, Jianhua Zhang, P. Andrew Futreal, Padmanee Sharma, James P. Allison, Zachary A. Cooper, Jennifer A. Wargo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/95f4f8da81aa4220b7ea3fea4b7af4b6
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spelling	oai:doaj.org-article:95f4f8da81aa4220b7ea3fea4b7af4b62021-12-02T12:34:18ZGenomic and immune heterogeneity are associated with differential responses to therapy in melanoma10.1038/s41525-017-0013-82056-7944https://doaj.org/article/95f4f8da81aa4220b7ea3fea4b7af4b62017-04-01T00:00:00Zhttps://doi.org/10.1038/s41525-017-0013-8https://doaj.org/toc/2056-7944Melanoma: Tumor differences within a patient may explain heterogeneous responses Patients with metastatic melanoma display molecular and immune differences across tumor sites associated with differential drug responses. A team led by Jennifer Wargo from the University of Texas MD Anderson Cancer Center, Houston, USA, studied the radiological responses of 60 patients with metastatic melanoma, half of whom received targeted drug therapy and half of whom received an immune checkpoint inhibitor. The majority (83%) showed differences in responses across metastases. The group then profiled tumors in a subset, and found molecular and immune heterogeneity in different tumors within the same patient. Heterogeneity in mutational and immune profiles within tumors from individual patients could explain differences in treatment response. Knowing this, the authors emphasize the importance of acquiring biopsies from more than one tumor site in order to best tailor therapies to the features of metastatic cancer.Alexandre ReubenChristine N. SpencerPeter A. PrietoVancheswaran GopalakrishnanSangeetha M. ReddyJohn P. MillerXizeng MaoMariana Petaccia De MacedoJiong ChenXingzhi SongHong JiangPei-Ling ChenHannah C. BeirdHaven R. GarberWhijae RohKhalida WaniEveline ChenCara HaymakerMarie-Andrée ForgetLatasha D. LittleCurtis GumbsRebecca L. ThorntonCourtney W. HudgensWei-Shen ChenJacob Austin-BrenemanRobert Szczepaniak SloaneLuigi NeziAlexandria P. CogdillChantale BernatchezJason RoszikPatrick HwuScott E. WoodmanLynda ChinHussein TawbiMichael A. DaviesJeffrey E. GershenwaldRodabe N. AmariaIsabella C. GlitzaAdi DiabSapna P. PatelJianhua HuJeffrey E. LeeElizabeth A. GrimmMichael T. TetzlaffAlexander J. LazarIgnacio I. WistubaKaren Clise-DwyerBrett W. CarterJianhua ZhangP. Andrew FutrealPadmanee SharmaJames P. AllisonZachary A. CooperJennifer A. WargoNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 2, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Alexandre Reuben Christine N. Spencer Peter A. Prieto Vancheswaran Gopalakrishnan Sangeetha M. Reddy John P. Miller Xizeng Mao Mariana Petaccia De Macedo Jiong Chen Xingzhi Song Hong Jiang Pei-Ling Chen Hannah C. Beird Haven R. Garber Whijae Roh Khalida Wani Eveline Chen Cara Haymaker Marie-Andrée Forget Latasha D. Little Curtis Gumbs Rebecca L. Thornton Courtney W. Hudgens Wei-Shen Chen Jacob Austin-Breneman Robert Szczepaniak Sloane Luigi Nezi Alexandria P. Cogdill Chantale Bernatchez Jason Roszik Patrick Hwu Scott E. Woodman Lynda Chin Hussein Tawbi Michael A. Davies Jeffrey E. Gershenwald Rodabe N. Amaria Isabella C. Glitza Adi Diab Sapna P. Patel Jianhua Hu Jeffrey E. Lee Elizabeth A. Grimm Michael T. Tetzlaff Alexander J. Lazar Ignacio I. Wistuba Karen Clise-Dwyer Brett W. Carter Jianhua Zhang P. Andrew Futreal Padmanee Sharma James P. Allison Zachary A. Cooper Jennifer A. Wargo Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
description	Melanoma: Tumor differences within a patient may explain heterogeneous responses Patients with metastatic melanoma display molecular and immune differences across tumor sites associated with differential drug responses. A team led by Jennifer Wargo from the University of Texas MD Anderson Cancer Center, Houston, USA, studied the radiological responses of 60 patients with metastatic melanoma, half of whom received targeted drug therapy and half of whom received an immune checkpoint inhibitor. The majority (83%) showed differences in responses across metastases. The group then profiled tumors in a subset, and found molecular and immune heterogeneity in different tumors within the same patient. Heterogeneity in mutational and immune profiles within tumors from individual patients could explain differences in treatment response. Knowing this, the authors emphasize the importance of acquiring biopsies from more than one tumor site in order to best tailor therapies to the features of metastatic cancer.
format	article
author	Alexandre Reuben Christine N. Spencer Peter A. Prieto Vancheswaran Gopalakrishnan Sangeetha M. Reddy John P. Miller Xizeng Mao Mariana Petaccia De Macedo Jiong Chen Xingzhi Song Hong Jiang Pei-Ling Chen Hannah C. Beird Haven R. Garber Whijae Roh Khalida Wani Eveline Chen Cara Haymaker Marie-Andrée Forget Latasha D. Little Curtis Gumbs Rebecca L. Thornton Courtney W. Hudgens Wei-Shen Chen Jacob Austin-Breneman Robert Szczepaniak Sloane Luigi Nezi Alexandria P. Cogdill Chantale Bernatchez Jason Roszik Patrick Hwu Scott E. Woodman Lynda Chin Hussein Tawbi Michael A. Davies Jeffrey E. Gershenwald Rodabe N. Amaria Isabella C. Glitza Adi Diab Sapna P. Patel Jianhua Hu Jeffrey E. Lee Elizabeth A. Grimm Michael T. Tetzlaff Alexander J. Lazar Ignacio I. Wistuba Karen Clise-Dwyer Brett W. Carter Jianhua Zhang P. Andrew Futreal Padmanee Sharma James P. Allison Zachary A. Cooper Jennifer A. Wargo
author_facet	Alexandre Reuben Christine N. Spencer Peter A. Prieto Vancheswaran Gopalakrishnan Sangeetha M. Reddy John P. Miller Xizeng Mao Mariana Petaccia De Macedo Jiong Chen Xingzhi Song Hong Jiang Pei-Ling Chen Hannah C. Beird Haven R. Garber Whijae Roh Khalida Wani Eveline Chen Cara Haymaker Marie-Andrée Forget Latasha D. Little Curtis Gumbs Rebecca L. Thornton Courtney W. Hudgens Wei-Shen Chen Jacob Austin-Breneman Robert Szczepaniak Sloane Luigi Nezi Alexandria P. Cogdill Chantale Bernatchez Jason Roszik Patrick Hwu Scott E. Woodman Lynda Chin Hussein Tawbi Michael A. Davies Jeffrey E. Gershenwald Rodabe N. Amaria Isabella C. Glitza Adi Diab Sapna P. Patel Jianhua Hu Jeffrey E. Lee Elizabeth A. Grimm Michael T. Tetzlaff Alexander J. Lazar Ignacio I. Wistuba Karen Clise-Dwyer Brett W. Carter Jianhua Zhang P. Andrew Futreal Padmanee Sharma James P. Allison Zachary A. Cooper Jennifer A. Wargo
author_sort	Alexandre Reuben
title	Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
title_short	Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
title_full	Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
title_fullStr	Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
title_full_unstemmed	Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
title_sort	genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/95f4f8da81aa4220b7ea3fea4b7af4b6
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Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma

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