STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas

STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas

The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule...

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Autores principales: Yi-Ru Pan, Chih-Cheng Chen, Yu-Tien Chan, Hsiao-Jung Wang, Fan-Tso Chien, Yeng-Long Chen, Jing-Lan Liu, Muh-Hwa Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/95f73b88a6d342eb9cd45626c936f80a
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spelling oai:doaj.org-article:95f73b88a6d342eb9cd45626c936f80a2021-12-02T15:34:49ZSTAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas10.1038/s41467-018-06134-z2041-1723https://doaj.org/article/95f73b88a6d342eb9cd45626c936f80a2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06134-zhttps://doaj.org/toc/2041-1723The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule dynamics to activate RhoA.Yi-Ru PanChih-Cheng ChenYu-Tien ChanHsiao-Jung WangFan-Tso ChienYeng-Long ChenJing-Lan LiuMuh-Hwa YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yi-Ru Pan
Chih-Cheng Chen
Yu-Tien Chan
Hsiao-Jung Wang
Fan-Tso Chien
Yeng-Long Chen
Jing-Lan Liu
Muh-Hwa Yang
STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
description The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule dynamics to activate RhoA.
format article
author Yi-Ru Pan
Chih-Cheng Chen
Yu-Tien Chan
Hsiao-Jung Wang
Fan-Tso Chien
Yeng-Long Chen
Jing-Lan Liu
Muh-Hwa Yang
author_facet Yi-Ru Pan
Chih-Cheng Chen
Yu-Tien Chan
Hsiao-Jung Wang
Fan-Tso Chien
Yeng-Long Chen
Jing-Lan Liu
Muh-Hwa Yang
author_sort Yi-Ru Pan
title STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
title_short STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
title_full STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
title_fullStr STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
title_full_unstemmed STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
title_sort stat3-coordinated migration facilitates the dissemination of diffuse large b-cell lymphomas
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/95f73b88a6d342eb9cd45626c936f80a
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