The JAK/STAT signaling pathway: from bench to clinic

Abstract The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the express...

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Autores principales:	Xiaoyi Hu, Jing li, Maorong Fu, Xia Zhao, Wei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/95f80005b470457aa1e03054a2091234
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spelling	oai:doaj.org-article:95f80005b470457aa1e03054a20912342021-11-28T12:08:39ZThe JAK/STAT signaling pathway: from bench to clinic10.1038/s41392-021-00791-12059-3635https://doaj.org/article/95f80005b470457aa1e03054a20912342021-11-01T00:00:00Zhttps://doi.org/10.1038/s41392-021-00791-1https://doaj.org/toc/2059-3635Abstract The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.Xiaoyi HuJing liMaorong FuXia ZhaoWei WangNature Publishing GrouparticleMedicineRBiology (General)QH301-705.5ENSignal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-33 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biology (General) QH301-705.5
spellingShingle	Medicine R Biology (General) QH301-705.5 Xiaoyi Hu Jing li Maorong Fu Xia Zhao Wei Wang The JAK/STAT signaling pathway: from bench to clinic
description	Abstract The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.
format	article
author	Xiaoyi Hu Jing li Maorong Fu Xia Zhao Wei Wang
author_facet	Xiaoyi Hu Jing li Maorong Fu Xia Zhao Wei Wang
author_sort	Xiaoyi Hu
title	The JAK/STAT signaling pathway: from bench to clinic
title_short	The JAK/STAT signaling pathway: from bench to clinic
title_full	The JAK/STAT signaling pathway: from bench to clinic
title_fullStr	The JAK/STAT signaling pathway: from bench to clinic
title_full_unstemmed	The JAK/STAT signaling pathway: from bench to clinic
title_sort	jak/stat signaling pathway: from bench to clinic
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/95f80005b470457aa1e03054a2091234
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The JAK/STAT signaling pathway: from bench to clinic

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