Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies

Over 90% of potential anti-cancer drug candidates results in translational failures in clinical trials. The main reason for this failure can be attributed to the non-accurate pre-clinical models that are being currently used for drug development and in personalised therapies. To ensure that the asse...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrew M. K. Law, Laura Rodriguez de la Fuente, Thomas J. Grundy, Guocheng Fang, Fatima Valdes-Mora, David Gallego-Ortega
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	3D culture systems personalised medicine drug resistance prevention tumor microenvironment 3D bioprinting extracellular matrix Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/95fb65fb5899476aa52b33cf93b7182e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:95fb65fb5899476aa52b33cf93b7182e
record_format	dspace
spelling	oai:doaj.org-article:95fb65fb5899476aa52b33cf93b7182e2021-12-01T18:04:19ZAdvancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies2234-943X10.3389/fonc.2021.782766https://doaj.org/article/95fb65fb5899476aa52b33cf93b7182e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.782766/fullhttps://doaj.org/toc/2234-943XOver 90% of potential anti-cancer drug candidates results in translational failures in clinical trials. The main reason for this failure can be attributed to the non-accurate pre-clinical models that are being currently used for drug development and in personalised therapies. To ensure that the assessment of drug efficacy and their mechanism of action have clinical translatability, the complexity of the tumor microenvironment needs to be properly modelled. 3D culture models are emerging as a powerful research tool that recapitulates in vivo characteristics. Technological advancements in this field show promising application in improving drug discovery, pre-clinical validation, and precision medicine. In this review, we discuss the significance of the tumor microenvironment and its impact on therapy success, the current developments of 3D culture, and the opportunities that advancements that in vitro technologies can provide to improve cancer therapeutics.Andrew M. K. LawAndrew M. K. LawLaura Rodriguez de la FuenteLaura Rodriguez de la FuenteLaura Rodriguez de la FuenteThomas J. GrundyGuocheng FangFatima Valdes-MoraFatima Valdes-MoraDavid Gallego-OrtegaDavid Gallego-OrtegaDavid Gallego-OrtegaFrontiers Media S.A.article3D culture systemspersonalised medicinedrug resistance preventiontumor microenvironment3D bioprintingextracellular matrixNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D culture systems personalised medicine drug resistance prevention tumor microenvironment 3D bioprinting extracellular matrix Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	3D culture systems personalised medicine drug resistance prevention tumor microenvironment 3D bioprinting extracellular matrix Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Andrew M. K. Law Andrew M. K. Law Laura Rodriguez de la Fuente Laura Rodriguez de la Fuente Laura Rodriguez de la Fuente Thomas J. Grundy Guocheng Fang Fatima Valdes-Mora Fatima Valdes-Mora David Gallego-Ortega David Gallego-Ortega David Gallego-Ortega Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies
description	Over 90% of potential anti-cancer drug candidates results in translational failures in clinical trials. The main reason for this failure can be attributed to the non-accurate pre-clinical models that are being currently used for drug development and in personalised therapies. To ensure that the assessment of drug efficacy and their mechanism of action have clinical translatability, the complexity of the tumor microenvironment needs to be properly modelled. 3D culture models are emerging as a powerful research tool that recapitulates in vivo characteristics. Technological advancements in this field show promising application in improving drug discovery, pre-clinical validation, and precision medicine. In this review, we discuss the significance of the tumor microenvironment and its impact on therapy success, the current developments of 3D culture, and the opportunities that advancements that in vitro technologies can provide to improve cancer therapeutics.
format	article
author	Andrew M. K. Law Andrew M. K. Law Laura Rodriguez de la Fuente Laura Rodriguez de la Fuente Laura Rodriguez de la Fuente Thomas J. Grundy Guocheng Fang Fatima Valdes-Mora Fatima Valdes-Mora David Gallego-Ortega David Gallego-Ortega David Gallego-Ortega
author_facet	Andrew M. K. Law Andrew M. K. Law Laura Rodriguez de la Fuente Laura Rodriguez de la Fuente Laura Rodriguez de la Fuente Thomas J. Grundy Guocheng Fang Fatima Valdes-Mora Fatima Valdes-Mora David Gallego-Ortega David Gallego-Ortega David Gallego-Ortega
author_sort	Andrew M. K. Law
title	Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies
title_short	Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies
title_full	Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies
title_fullStr	Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies
title_full_unstemmed	Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies
title_sort	advancements in 3d cell culture systems for personalizing anti-cancer therapies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/95fb65fb5899476aa52b33cf93b7182e
work_keys_str_mv	AT andrewmklaw advancementsin3dcellculturesystemsforpersonalizinganticancertherapies AT andrewmklaw advancementsin3dcellculturesystemsforpersonalizinganticancertherapies AT laurarodriguezdelafuente advancementsin3dcellculturesystemsforpersonalizinganticancertherapies AT laurarodriguezdelafuente advancementsin3dcellculturesystemsforpersonalizinganticancertherapies AT laurarodriguezdelafuente advancementsin3dcellculturesystemsforpersonalizinganticancertherapies AT thomasjgrundy advancementsin3dcellculturesystemsforpersonalizinganticancertherapies AT guochengfang advancementsin3dcellculturesystemsforpersonalizinganticancertherapies AT fatimavaldesmora advancementsin3dcellculturesystemsforpersonalizinganticancertherapies AT fatimavaldesmora advancementsin3dcellculturesystemsforpersonalizinganticancertherapies AT davidgallegoortega advancementsin3dcellculturesystemsforpersonalizinganticancertherapies AT davidgallegoortega advancementsin3dcellculturesystemsforpersonalizinganticancertherapies AT davidgallegoortega advancementsin3dcellculturesystemsforpersonalizinganticancertherapies
_version_	1718404765486940160

Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies

Ejemplares similares