The effect of recombinant human interferon α1b treatment of infants hospitalized with lower respiratory tract infection on subsequent wheezing

The effect of recombinant human interferon α1b treatment of infants hospitalized with lower respiratory tract infection on subsequent wheezing

Objective: To investigate the impact of recombinant human interferon α1b (rhIFNα1b) treatment in infants hospitalized with lower respiratory tract infections on subsequent wheezing. Methods: The clinical data of infants (n = 540) with viral pneumonia, wheezy bronchitis, or bronchiolitis hospitalized...

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Autores principales: Lihua Yang, Guocheng Zhang, Lusheng Huang, Xiaoling Ren, Yanqi Su, Chengxiu Wang, Yuanbin Shi, Liao Li, Hui Shan, Jing Chen, Jianxin Xiong, Xue Xue, Shaofeng Song, Li Zhao, Shuhua An, Haiming Yu, Hong Cao, Lin Zhao, Ming Li, Xiaocui Sheng, Yajun Wang
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
Wheezing
Infant
Lower respiratory tract infection
Recombinant human interferon α1b
Breastfeeding
Pediatrics
RJ1-570
Acceso en línea:https://doaj.org/article/95fbcbfea8c845a0bf010b9a085f67a2
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spelling oai:doaj.org-article:95fbcbfea8c845a0bf010b9a085f67a22021-11-06T04:12:49ZThe effect of recombinant human interferon α1b treatment of infants hospitalized with lower respiratory tract infection on subsequent wheezing0021-755710.1016/j.jped.2020.12.005https://doaj.org/article/95fbcbfea8c845a0bf010b9a085f67a22021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0021755721000309https://doaj.org/toc/0021-7557Objective: To investigate the impact of recombinant human interferon α1b (rhIFNα1b) treatment in infants hospitalized with lower respiratory tract infections on subsequent wheezing. Methods: The clinical data of infants (n = 540) with viral pneumonia, wheezy bronchitis, or bronchiolitis hospitalized in 19 Chinese hospitals from June 2009 to June 2015 were retrospectively analyzed. The parameters relevant to wheezing episodes within the last year were collected by telephone and questionnaires. The rhIFNα1b treatment group (n = 253) and control group (n = 287) were compared in terms of wheezing episodes within the last year. Moreover, the wheezing group (95 cases) and non-wheezing group (445 cases) were compared. Results: Out of 540 cases, 95 (17.6%) experienced wheezing episodes, 13.8% (35/253) cases treated with rhIFNα1b, and 20.9% (60/287) cases without rhIFNα1b experienced wheezing episodes within the last year. The rhIFNα1b treatment significantly improved wheezing episodes within the last year, compared with the control peers (p = 0.031). Single-factor regression showed statistically significant differences between the wheezing and non-wheezing groups in terms of age, rhIFNα1b use, childhood and family history of allergy, housing situation, and feeding history (p < 0.05). Binary logistic regression showed a childhood history of allergy (OR = 2.14, p = 0.004), no rhIFNα1b use (OR = 1.70, p = 0.028), and living in a crowded house (OR = 1.92, p = 0.012) might be risk factors of subsequent wheezing. Accordingly, breastfeeding (OR = 0.44, p = 0.008) and hospitalization age of ≤1-year-old (OR = 0.58, p = 0.024) were protective factors. Conclusions: Early use of rhIFNα1b in infants hospitalized with lower respiratory tract infections and breastfeeding could prevent subsequent wheezing. Living in a crowded house could promote subsequent wheezing.Lihua YangGuocheng ZhangLusheng HuangXiaoling RenYanqi SuChengxiu WangYuanbin ShiLiao LiHui ShanJing ChenJianxin XiongXue XueShaofeng SongLi ZhaoShuhua AnHaiming YuHong CaoLin ZhaoMing LiXiaocui ShengYajun WangElsevierarticleWheezingInfantLower respiratory tract infectionRecombinant human interferon α1bBreastfeedingPediatricsRJ1-570ENJornal de Pediatria, Vol 97, Iss 6, Pp 617-622 (2021)
institution DOAJ
collection DOAJ
language EN
topic Wheezing
Infant
Lower respiratory tract infection
Recombinant human interferon α1b
Breastfeeding
Pediatrics
RJ1-570
spellingShingle Wheezing
Infant
Lower respiratory tract infection
Recombinant human interferon α1b
Breastfeeding
Pediatrics
RJ1-570
Lihua Yang
Guocheng Zhang
Lusheng Huang
Xiaoling Ren
Yanqi Su
Chengxiu Wang
Yuanbin Shi
Liao Li
Hui Shan
Jing Chen
Jianxin Xiong
Xue Xue
Shaofeng Song
Li Zhao
Shuhua An
Haiming Yu
Hong Cao
Lin Zhao
Ming Li
Xiaocui Sheng
Yajun Wang
The effect of recombinant human interferon α1b treatment of infants hospitalized with lower respiratory tract infection on subsequent wheezing
description Objective: To investigate the impact of recombinant human interferon α1b (rhIFNα1b) treatment in infants hospitalized with lower respiratory tract infections on subsequent wheezing. Methods: The clinical data of infants (n = 540) with viral pneumonia, wheezy bronchitis, or bronchiolitis hospitalized in 19 Chinese hospitals from June 2009 to June 2015 were retrospectively analyzed. The parameters relevant to wheezing episodes within the last year were collected by telephone and questionnaires. The rhIFNα1b treatment group (n = 253) and control group (n = 287) were compared in terms of wheezing episodes within the last year. Moreover, the wheezing group (95 cases) and non-wheezing group (445 cases) were compared. Results: Out of 540 cases, 95 (17.6%) experienced wheezing episodes, 13.8% (35/253) cases treated with rhIFNα1b, and 20.9% (60/287) cases without rhIFNα1b experienced wheezing episodes within the last year. The rhIFNα1b treatment significantly improved wheezing episodes within the last year, compared with the control peers (p = 0.031). Single-factor regression showed statistically significant differences between the wheezing and non-wheezing groups in terms of age, rhIFNα1b use, childhood and family history of allergy, housing situation, and feeding history (p < 0.05). Binary logistic regression showed a childhood history of allergy (OR = 2.14, p = 0.004), no rhIFNα1b use (OR = 1.70, p = 0.028), and living in a crowded house (OR = 1.92, p = 0.012) might be risk factors of subsequent wheezing. Accordingly, breastfeeding (OR = 0.44, p = 0.008) and hospitalization age of ≤1-year-old (OR = 0.58, p = 0.024) were protective factors. Conclusions: Early use of rhIFNα1b in infants hospitalized with lower respiratory tract infections and breastfeeding could prevent subsequent wheezing. Living in a crowded house could promote subsequent wheezing.
format article
author Lihua Yang
Guocheng Zhang
Lusheng Huang
Xiaoling Ren
Yanqi Su
Chengxiu Wang
Yuanbin Shi
Liao Li
Hui Shan
Jing Chen
Jianxin Xiong
Xue Xue
Shaofeng Song
Li Zhao
Shuhua An
Haiming Yu
Hong Cao
Lin Zhao
Ming Li
Xiaocui Sheng
Yajun Wang
author_facet Lihua Yang
Guocheng Zhang
Lusheng Huang
Xiaoling Ren
Yanqi Su
Chengxiu Wang
Yuanbin Shi
Liao Li
Hui Shan
Jing Chen
Jianxin Xiong
Xue Xue
Shaofeng Song
Li Zhao
Shuhua An
Haiming Yu
Hong Cao
Lin Zhao
Ming Li
Xiaocui Sheng
Yajun Wang
author_sort Lihua Yang
title The effect of recombinant human interferon α1b treatment of infants hospitalized with lower respiratory tract infection on subsequent wheezing
title_short The effect of recombinant human interferon α1b treatment of infants hospitalized with lower respiratory tract infection on subsequent wheezing
title_full The effect of recombinant human interferon α1b treatment of infants hospitalized with lower respiratory tract infection on subsequent wheezing
title_fullStr The effect of recombinant human interferon α1b treatment of infants hospitalized with lower respiratory tract infection on subsequent wheezing
title_full_unstemmed The effect of recombinant human interferon α1b treatment of infants hospitalized with lower respiratory tract infection on subsequent wheezing
title_sort effect of recombinant human interferon α1b treatment of infants hospitalized with lower respiratory tract infection on subsequent wheezing
publisher Elsevier
publishDate 2021
url https://doaj.org/article/95fbcbfea8c845a0bf010b9a085f67a2
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