Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms

Developing an in vitro blood-brain-barrier (BBB) model that reproduces the organ’s complex structure and function is an open challenge. Here the authors present a BBB-on-a-chip that includes endothelial cells, pericytes and a 3D astrocytic network which resembles the morphology and function of astro...

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Autores principales:	Song Ih Ahn, Yoshitaka J. Sei, Hyun-Ji Park, Jinhwan Kim, Yujung Ryu, Jeongmoon J. Choi, Hak-Joon Sung, Tobey J. MacDonald, Allan I. Levey, YongTae Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95fd2b9d6594462fac69a3cba4e9f50b
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spelling	oai:doaj.org-article:95fd2b9d6594462fac69a3cba4e9f50b2021-12-02T14:42:13ZMicroengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms10.1038/s41467-019-13896-72041-1723https://doaj.org/article/95fd2b9d6594462fac69a3cba4e9f50b2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13896-7https://doaj.org/toc/2041-1723Developing an in vitro blood-brain-barrier (BBB) model that reproduces the organ’s complex structure and function is an open challenge. Here the authors present a BBB-on-a-chip that includes endothelial cells, pericytes and a 3D astrocytic network which resembles the morphology and function of astrocytes in the BBB in vivo.Song Ih AhnYoshitaka J. SeiHyun-Ji ParkJinhwan KimYujung RyuJeongmoon J. ChoiHak-Joon SungTobey J. MacDonaldAllan I. LeveyYongTae KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Song Ih Ahn Yoshitaka J. Sei Hyun-Ji Park Jinhwan Kim Yujung Ryu Jeongmoon J. Choi Hak-Joon Sung Tobey J. MacDonald Allan I. Levey YongTae Kim Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
description	Developing an in vitro blood-brain-barrier (BBB) model that reproduces the organ’s complex structure and function is an open challenge. Here the authors present a BBB-on-a-chip that includes endothelial cells, pericytes and a 3D astrocytic network which resembles the morphology and function of astrocytes in the BBB in vivo.
format	article
author	Song Ih Ahn Yoshitaka J. Sei Hyun-Ji Park Jinhwan Kim Yujung Ryu Jeongmoon J. Choi Hak-Joon Sung Tobey J. MacDonald Allan I. Levey YongTae Kim
author_facet	Song Ih Ahn Yoshitaka J. Sei Hyun-Ji Park Jinhwan Kim Yujung Ryu Jeongmoon J. Choi Hak-Joon Sung Tobey J. MacDonald Allan I. Levey YongTae Kim
author_sort	Song Ih Ahn
title	Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
title_short	Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
title_full	Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
title_fullStr	Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
title_full_unstemmed	Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
title_sort	microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/95fd2b9d6594462fac69a3cba4e9f50b
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_version_	1718389766058147840

Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms

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