Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis

CREB-regulated transcription coactivator 2, CRTC2, has been associated with regulation of glucose and lipid homeostasis. Here Han et al. show that Creb/Crtc2 modulates lipid and glucose metabolism by inhibiting the expression of mi-R34 that, in turn, represses the expression of Sirt1 and PPARα and c...

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Autores principales:	Hye-Sook Han, Byeong Hun Choi, Jun Seok Kim, Geon Kang, Seung-Hoi Koo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95fe6a39c576491889a4a394d3aca70c
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spelling	oai:doaj.org-article:95fe6a39c576491889a4a394d3aca70c2021-12-02T17:06:00ZHepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis10.1038/s41467-017-01878-62041-1723https://doaj.org/article/95fe6a39c576491889a4a394d3aca70c2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01878-6https://doaj.org/toc/2041-1723CREB-regulated transcription coactivator 2, CRTC2, has been associated with regulation of glucose and lipid homeostasis. Here Han et al. show that Creb/Crtc2 modulates lipid and glucose metabolism by inhibiting the expression of mi-R34 that, in turn, represses the expression of Sirt1 and PPARα and consequently Fgf21 levels.Hye-Sook HanByeong Hun ChoiJun Seok KimGeon KangSeung-Hoi KooNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hye-Sook Han Byeong Hun Choi Jun Seok Kim Geon Kang Seung-Hoi Koo Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
description	CREB-regulated transcription coactivator 2, CRTC2, has been associated with regulation of glucose and lipid homeostasis. Here Han et al. show that Creb/Crtc2 modulates lipid and glucose metabolism by inhibiting the expression of mi-R34 that, in turn, represses the expression of Sirt1 and PPARα and consequently Fgf21 levels.
format	article
author	Hye-Sook Han Byeong Hun Choi Jun Seok Kim Geon Kang Seung-Hoi Koo
author_facet	Hye-Sook Han Byeong Hun Choi Jun Seok Kim Geon Kang Seung-Hoi Koo
author_sort	Hye-Sook Han
title	Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
title_short	Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
title_full	Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
title_fullStr	Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
title_full_unstemmed	Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
title_sort	hepatic crtc2 controls whole body energy metabolism via a mir-34a-fgf21 axis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/95fe6a39c576491889a4a394d3aca70c
work_keys_str_mv	AT hyesookhan hepaticcrtc2controlswholebodyenergymetabolismviaamir34afgf21axis AT byeonghunchoi hepaticcrtc2controlswholebodyenergymetabolismviaamir34afgf21axis AT junseokkim hepaticcrtc2controlswholebodyenergymetabolismviaamir34afgf21axis AT geonkang hepaticcrtc2controlswholebodyenergymetabolismviaamir34afgf21axis AT seunghoikoo hepaticcrtc2controlswholebodyenergymetabolismviaamir34afgf21axis
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Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis

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