Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis

CREB-regulated transcription coactivator 2, CRTC2, has been associated with regulation of glucose and lipid homeostasis. Here Han et al. show that Creb/Crtc2 modulates lipid and glucose metabolism by inhibiting the expression of mi-R34 that, in turn, represses the expression of Sirt1 and PPARα and c...

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Autores principales: Hye-Sook Han, Byeong Hun Choi, Jun Seok Kim, Geon Kang, Seung-Hoi Koo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/95fe6a39c576491889a4a394d3aca70c
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