Highly sensitive non-enzymatic electrochemical glucose sensor based on dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures

Abstract A high-performance non-enzymatic glucose sensor based on hybrid metal-oxides is proposed. Dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures (CuO/ZnO-DSDSHNM) were prepared via the hydrothermal method using pluronic F-127 as a surfactant. This structure is studied by v...

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Autores principales:	Zahra Haghparas, Zoheir Kordrostami, Mohsen Sorouri, Maryam Rajabzadeh, Reza Khalifeh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/95fe6b8a1e3348ccb390ffc8d01231f5
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spelling	oai:doaj.org-article:95fe6b8a1e3348ccb390ffc8d01231f52021-12-02T15:23:08ZHighly sensitive non-enzymatic electrochemical glucose sensor based on dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures10.1038/s41598-020-79460-22045-2322https://doaj.org/article/95fe6b8a1e3348ccb390ffc8d01231f52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79460-2https://doaj.org/toc/2045-2322Abstract A high-performance non-enzymatic glucose sensor based on hybrid metal-oxides is proposed. Dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures (CuO/ZnO-DSDSHNM) were prepared via the hydrothermal method using pluronic F-127 as a surfactant. This structure is studied by various physicochemical characterizations such as scanning electron microscopy, X-ray diffraction spectroscopy, inductively coupled plasma atomic emission spectroscopy, elemental mapping techniques, X-ray photoelectron spectroscopy, and transmission electron microscopy. This unique CuO/ZnO-DSDSHNM provides both a large surface area and an easy penetrable structure facilitating improved electrochemical reactivity toward glucose oxidation. The prepared CuO/ZnO-DSDSHNM was used over the glassy carbon electrode (GCE) as the active material for glucose detection and then coated by Nafion to provide the proposed Nafion/CuO/ZnO-DSDSHNM/GCE. The fabricated glucose sensor exhibits an extremely wide dynamic range from 500 nM to 100 mM, a sensitivity of 1536.80 µA mM−1 cm−2, a low limit of detection of 357.5 nM, and a short response time of 1.60 s. The proposed sensor also showed long-term stability, good reproducibility, favorable repeatability, excellent selectivity, and satisfactory applicability for glucose detection in human serum samples. The achieved high-performance glucose sensing based on Nafion/CuO/ZnO-DSDSHNM/GCE shows that both the material synthesis and the sensor fabrication methods have been promising and they can be used in future researches.Zahra HaghparasZoheir KordrostamiMohsen SorouriMaryam RajabzadehReza KhalifehNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zahra Haghparas Zoheir Kordrostami Mohsen Sorouri Maryam Rajabzadeh Reza Khalifeh Highly sensitive non-enzymatic electrochemical glucose sensor based on dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures
description	Abstract A high-performance non-enzymatic glucose sensor based on hybrid metal-oxides is proposed. Dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures (CuO/ZnO-DSDSHNM) were prepared via the hydrothermal method using pluronic F-127 as a surfactant. This structure is studied by various physicochemical characterizations such as scanning electron microscopy, X-ray diffraction spectroscopy, inductively coupled plasma atomic emission spectroscopy, elemental mapping techniques, X-ray photoelectron spectroscopy, and transmission electron microscopy. This unique CuO/ZnO-DSDSHNM provides both a large surface area and an easy penetrable structure facilitating improved electrochemical reactivity toward glucose oxidation. The prepared CuO/ZnO-DSDSHNM was used over the glassy carbon electrode (GCE) as the active material for glucose detection and then coated by Nafion to provide the proposed Nafion/CuO/ZnO-DSDSHNM/GCE. The fabricated glucose sensor exhibits an extremely wide dynamic range from 500 nM to 100 mM, a sensitivity of 1536.80 µA mM−1 cm−2, a low limit of detection of 357.5 nM, and a short response time of 1.60 s. The proposed sensor also showed long-term stability, good reproducibility, favorable repeatability, excellent selectivity, and satisfactory applicability for glucose detection in human serum samples. The achieved high-performance glucose sensing based on Nafion/CuO/ZnO-DSDSHNM/GCE shows that both the material synthesis and the sensor fabrication methods have been promising and they can be used in future researches.
format	article
author	Zahra Haghparas Zoheir Kordrostami Mohsen Sorouri Maryam Rajabzadeh Reza Khalifeh
author_facet	Zahra Haghparas Zoheir Kordrostami Mohsen Sorouri Maryam Rajabzadeh Reza Khalifeh
author_sort	Zahra Haghparas
title	Highly sensitive non-enzymatic electrochemical glucose sensor based on dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures
title_short	Highly sensitive non-enzymatic electrochemical glucose sensor based on dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures
title_full	Highly sensitive non-enzymatic electrochemical glucose sensor based on dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures
title_fullStr	Highly sensitive non-enzymatic electrochemical glucose sensor based on dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures
title_full_unstemmed	Highly sensitive non-enzymatic electrochemical glucose sensor based on dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures
title_sort	highly sensitive non-enzymatic electrochemical glucose sensor based on dumbbell-shaped double-shelled hollow nanoporous cuo/zno microstructures
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/95fe6b8a1e3348ccb390ffc8d01231f5
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Highly sensitive non-enzymatic electrochemical glucose sensor based on dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures

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