Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

Agonistic CD40 antibodies (αCD40) have broad immunostimulatory properties, however their efficacy in glioma remains unclear. Here the authors show that αCD40 promotes the formation of tertiary lymphoid structures but does not improve survival and impairs the response to immune checkpoint blockade in...

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Autores principales: Luuk van Hooren, Alessandra Vaccaro, Mohanraj Ramachandran, Konstantinos Vazaios, Sylwia Libard, Tiarne van de Walle, Maria Georganaki, Hua Huang, Ilkka Pietilä, Joey Lau, Maria H. Ulvmar, Mikael C. I. Karlsson, Maria Zetterling, Sara M. Mangsbo, Asgeir S. Jakola, Thomas Olsson Bontell, Anja Smits, Magnus Essand, Anna Dimberg
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/960c23767579410eb75556847b8c9b3f
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spelling oai:doaj.org-article:960c23767579410eb75556847b8c9b3f2021-12-02T18:33:59ZAgonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma10.1038/s41467-021-24347-72041-1723https://doaj.org/article/960c23767579410eb75556847b8c9b3f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24347-7https://doaj.org/toc/2041-1723Agonistic CD40 antibodies (αCD40) have broad immunostimulatory properties, however their efficacy in glioma remains unclear. Here the authors show that αCD40 promotes the formation of tertiary lymphoid structures but does not improve survival and impairs the response to immune checkpoint blockade in murine glioma models.Luuk van HoorenAlessandra VaccaroMohanraj RamachandranKonstantinos VazaiosSylwia LibardTiarne van de WalleMaria GeorganakiHua HuangIlkka PietiläJoey LauMaria H. UlvmarMikael C. I. KarlssonMaria ZetterlingSara M. MangsboAsgeir S. JakolaThomas Olsson BontellAnja SmitsMagnus EssandAnna DimbergNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Luuk van Hooren
Alessandra Vaccaro
Mohanraj Ramachandran
Konstantinos Vazaios
Sylwia Libard
Tiarne van de Walle
Maria Georganaki
Hua Huang
Ilkka Pietilä
Joey Lau
Maria H. Ulvmar
Mikael C. I. Karlsson
Maria Zetterling
Sara M. Mangsbo
Asgeir S. Jakola
Thomas Olsson Bontell
Anja Smits
Magnus Essand
Anna Dimberg
Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
description Agonistic CD40 antibodies (αCD40) have broad immunostimulatory properties, however their efficacy in glioma remains unclear. Here the authors show that αCD40 promotes the formation of tertiary lymphoid structures but does not improve survival and impairs the response to immune checkpoint blockade in murine glioma models.
format article
author Luuk van Hooren
Alessandra Vaccaro
Mohanraj Ramachandran
Konstantinos Vazaios
Sylwia Libard
Tiarne van de Walle
Maria Georganaki
Hua Huang
Ilkka Pietilä
Joey Lau
Maria H. Ulvmar
Mikael C. I. Karlsson
Maria Zetterling
Sara M. Mangsbo
Asgeir S. Jakola
Thomas Olsson Bontell
Anja Smits
Magnus Essand
Anna Dimberg
author_facet Luuk van Hooren
Alessandra Vaccaro
Mohanraj Ramachandran
Konstantinos Vazaios
Sylwia Libard
Tiarne van de Walle
Maria Georganaki
Hua Huang
Ilkka Pietilä
Joey Lau
Maria H. Ulvmar
Mikael C. I. Karlsson
Maria Zetterling
Sara M. Mangsbo
Asgeir S. Jakola
Thomas Olsson Bontell
Anja Smits
Magnus Essand
Anna Dimberg
author_sort Luuk van Hooren
title Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
title_short Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
title_full Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
title_fullStr Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
title_full_unstemmed Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
title_sort agonistic cd40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/960c23767579410eb75556847b8c9b3f
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