Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.

Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed "click" reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-r...

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Autores principales:	Anthony T S Lo, Noeris K Salam, David E Hibbs, Peter J Rutledge, Matthew H Todd
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/960d9000aebd4e979253594fa32617f3
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spelling	oai:doaj.org-article:960d9000aebd4e979253594fa32617f32021-11-18T06:54:15ZPolyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.1932-620310.1371/journal.pone.0017446https://doaj.org/article/960d9000aebd4e979253594fa32617f32011-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21573061/?tool=EBIhttps://doaj.org/toc/1932-6203Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed "click" reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodynamic profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail.Anthony T S LoNoeris K SalamDavid E HibbsPeter J RutledgeMatthew H ToddPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e17446 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anthony T S Lo Noeris K Salam David E Hibbs Peter J Rutledge Matthew H Todd Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.
description	Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed "click" reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodynamic profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail.
format	article
author	Anthony T S Lo Noeris K Salam David E Hibbs Peter J Rutledge Matthew H Todd
author_facet	Anthony T S Lo Noeris K Salam David E Hibbs Peter J Rutledge Matthew H Todd
author_sort	Anthony T S Lo
title	Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.
title_short	Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.
title_full	Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.
title_fullStr	Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.
title_full_unstemmed	Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.
title_sort	polyamide-scorpion cyclam lexitropsins selectively bind at-rich dna independently of the nature of the coordinated metal.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/960d9000aebd4e979253594fa32617f3
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Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.

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