HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China
Abstract The goal of this study was to assess risk factors associated with HIV/AIDS progression. Between May 2007 and December 2014, 114 subjects were enrolled in Wuxi City and examined every 6 months. The pol gene sequence was amplified to ascertain the HIV-1 subtype. A Cox proportional hazards reg...
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Nature Portfolio
2017
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oai:doaj.org-article:960e0e1cfcc24b5d862bc212eff579312021-12-02T12:32:20ZHIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China10.1038/s41598-017-01858-22045-2322https://doaj.org/article/960e0e1cfcc24b5d862bc212eff579312017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01858-2https://doaj.org/toc/2045-2322Abstract The goal of this study was to assess risk factors associated with HIV/AIDS progression. Between May 2007 and December 2014, 114 subjects were enrolled in Wuxi City and examined every 6 months. The pol gene sequence was amplified to ascertain the HIV-1 subtype. A Cox proportional hazards regression model was used to estimate the factors associated with HIV/AIDS progression. The median follow-up time for all 114 subjects was 26.70 months (IQR: 18.50–41.47), while the median progression time of the 38 progressed subjects was 24.80 months (IQR: 14.13–34.38). Overall, the CRF01_AE subtype was correlated with a significant risk of accelerated progression compared to non-CRF01_AE subtypes (HR = 3.14, 95%CI: 1.39–7.08, P = 0.006). In addition, a lower CD4 count (350–499) at baseline was associated with a risk of accelerated HIV/AIDS progression compared to higher CD4 count (≥500) (HR = 4.38, 95%CI: 1.95–9.82, P < 0.001). Furthermore, interaction analyses showed that HIV-1 subtypes interacted multiplicatively with transmission routes or CD4 count at baseline to contribute to HIV/AIDS progression (P = 0.023 and P < 0.001, respectively). In conclusion, the CRF01_AE subtype and a lower CD4 count at baseline tend to be associated with the faster progression of HIV/AIDS. Understanding the factors affecting HIV/AIDS progression is crucial for developing personalized management and clinical counselling strategies.Minjie ChuWuhong ZhangXuan ZhangWenjie JiangXiping HuanXiaojun MengBowen ZhuYue YangYusha TaoTian TianYihua LuLiying JiangLei ZhangXun ZhuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
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Medicine R Science Q Minjie Chu Wuhong Zhang Xuan Zhang Wenjie Jiang Xiping Huan Xiaojun Meng Bowen Zhu Yue Yang Yusha Tao Tian Tian Yihua Lu Liying Jiang Lei Zhang Xun Zhuang HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China |
| description |
Abstract The goal of this study was to assess risk factors associated with HIV/AIDS progression. Between May 2007 and December 2014, 114 subjects were enrolled in Wuxi City and examined every 6 months. The pol gene sequence was amplified to ascertain the HIV-1 subtype. A Cox proportional hazards regression model was used to estimate the factors associated with HIV/AIDS progression. The median follow-up time for all 114 subjects was 26.70 months (IQR: 18.50–41.47), while the median progression time of the 38 progressed subjects was 24.80 months (IQR: 14.13–34.38). Overall, the CRF01_AE subtype was correlated with a significant risk of accelerated progression compared to non-CRF01_AE subtypes (HR = 3.14, 95%CI: 1.39–7.08, P = 0.006). In addition, a lower CD4 count (350–499) at baseline was associated with a risk of accelerated HIV/AIDS progression compared to higher CD4 count (≥500) (HR = 4.38, 95%CI: 1.95–9.82, P < 0.001). Furthermore, interaction analyses showed that HIV-1 subtypes interacted multiplicatively with transmission routes or CD4 count at baseline to contribute to HIV/AIDS progression (P = 0.023 and P < 0.001, respectively). In conclusion, the CRF01_AE subtype and a lower CD4 count at baseline tend to be associated with the faster progression of HIV/AIDS. Understanding the factors affecting HIV/AIDS progression is crucial for developing personalized management and clinical counselling strategies. |
| format |
article |
| author |
Minjie Chu Wuhong Zhang Xuan Zhang Wenjie Jiang Xiping Huan Xiaojun Meng Bowen Zhu Yue Yang Yusha Tao Tian Tian Yihua Lu Liying Jiang Lei Zhang Xun Zhuang |
| author_facet |
Minjie Chu Wuhong Zhang Xuan Zhang Wenjie Jiang Xiping Huan Xiaojun Meng Bowen Zhu Yue Yang Yusha Tao Tian Tian Yihua Lu Liying Jiang Lei Zhang Xun Zhuang |
| author_sort |
Minjie Chu |
| title |
HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China |
| title_short |
HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China |
| title_full |
HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China |
| title_fullStr |
HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China |
| title_full_unstemmed |
HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China |
| title_sort |
hiv-1 crf01_ae strain is associated with faster hiv/aids progression in jiangsu province, china |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/960e0e1cfcc24b5d862bc212eff57931 |
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