A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects

The tibia of New Zealand White rabbits was used as a model of critical bone defects to investigate a new design of composite scaffold for bone defects composed of dual materials. The all-in-one design of a titanium alloy (Ti-6Al-4V) scaffold comprised the structure of a bone plate and gradient poros...

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Autores principales:	Cheng-Tang Pan, Wen-Hsin Hsu, Yu-Shun Cheng, Zhi-Hong Wen, Wen-Fan Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	critical bone defect composite scaffold porosity Ti-6Al-4V hydroxyapatite finite element analysis Mechanical engineering and machinery TJ1-1570
Acceso en línea:	https://doaj.org/article/960ec7b72b5e4eeba207da1b8ef64b58
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spelling	oai:doaj.org-article:960ec7b72b5e4eeba207da1b8ef64b582021-11-25T18:22:53ZA New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects10.3390/mi121112942072-666Xhttps://doaj.org/article/960ec7b72b5e4eeba207da1b8ef64b582021-10-01T00:00:00Zhttps://www.mdpi.com/2072-666X/12/11/1294https://doaj.org/toc/2072-666XThe tibia of New Zealand White rabbits was used as a model of critical bone defects to investigate a new design of composite scaffold for bone defects composed of dual materials. The all-in-one design of a titanium alloy (Ti-6Al-4V) scaffold comprised the structure of a bone plate and gradient porosity cage. Hydroxyapatite (HAp), a biodegradable material, was encapsulated in the center of the scaffold. The gradient pore structure was designed with 70%-65%-60%-55%-50% porosity, since the stresses could be distributed more uniformly when the all-in-one scaffold was placed on the bone contact surface. By covering the center of the scaffold with a low strength of HAp to contact the relatively low strength of bone marrow tissues, the excessive stiffness of the Ti-6Al-4V can be effectively reduced and further diminish the incidence of the stress shielding effect. The simulation results show that the optimized composite scaffold for the 3D model of tibia had a maximum stress value of 27.862 MPa and a maximum strain of 0.065%. The scaffold prepared by selective laser melting was annealed and found that the Young’s coefficient increased from 126.44 GPa to 131.46 GPa, the hardness increased from 3.9 GPa to 4.12 GPa, and the strain decreased from 2.27% to 1.13%. The result demonstrates that the removal of residual stress can lead to a more stable structural strength, which can be used as a reference for the design of future clinical tibial defect repair scaffolds.Cheng-Tang PanWen-Hsin HsuYu-Shun ChengZhi-Hong WenWen-Fan ChenMDPI AGarticlecritical bone defectcomposite scaffoldporosityTi-6Al-4Vhydroxyapatitefinite element analysisMechanical engineering and machineryTJ1-1570ENMicromachines, Vol 12, Iss 1294, p 1294 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	critical bone defect composite scaffold porosity Ti-6Al-4V hydroxyapatite finite element analysis Mechanical engineering and machinery TJ1-1570
spellingShingle	critical bone defect composite scaffold porosity Ti-6Al-4V hydroxyapatite finite element analysis Mechanical engineering and machinery TJ1-1570 Cheng-Tang Pan Wen-Hsin Hsu Yu-Shun Cheng Zhi-Hong Wen Wen-Fan Chen A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
description	The tibia of New Zealand White rabbits was used as a model of critical bone defects to investigate a new design of composite scaffold for bone defects composed of dual materials. The all-in-one design of a titanium alloy (Ti-6Al-4V) scaffold comprised the structure of a bone plate and gradient porosity cage. Hydroxyapatite (HAp), a biodegradable material, was encapsulated in the center of the scaffold. The gradient pore structure was designed with 70%-65%-60%-55%-50% porosity, since the stresses could be distributed more uniformly when the all-in-one scaffold was placed on the bone contact surface. By covering the center of the scaffold with a low strength of HAp to contact the relatively low strength of bone marrow tissues, the excessive stiffness of the Ti-6Al-4V can be effectively reduced and further diminish the incidence of the stress shielding effect. The simulation results show that the optimized composite scaffold for the 3D model of tibia had a maximum stress value of 27.862 MPa and a maximum strain of 0.065%. The scaffold prepared by selective laser melting was annealed and found that the Young’s coefficient increased from 126.44 GPa to 131.46 GPa, the hardness increased from 3.9 GPa to 4.12 GPa, and the strain decreased from 2.27% to 1.13%. The result demonstrates that the removal of residual stress can lead to a more stable structural strength, which can be used as a reference for the design of future clinical tibial defect repair scaffolds.
format	article
author	Cheng-Tang Pan Wen-Hsin Hsu Yu-Shun Cheng Zhi-Hong Wen Wen-Fan Chen
author_facet	Cheng-Tang Pan Wen-Hsin Hsu Yu-Shun Cheng Zhi-Hong Wen Wen-Fan Chen
author_sort	Cheng-Tang Pan
title	A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
title_short	A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
title_full	A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
title_fullStr	A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
title_full_unstemmed	A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
title_sort	new design of porosity gradient ti-6al-4v encapsulated hydroxyapatite dual materials composite scaffold for bone defects
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/960ec7b72b5e4eeba207da1b8ef64b58
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A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects

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