Bioprospecting Antimicrobials from Lactiplantibacillus plantarum: Key Factors Underlying Its Probiotic Action

Lactiplantibacillus plantarum (L. plantarum) is a well-studied and versatile species of lactobacilli. It is found in several niches, including human mucosal surfaces, and it is largely employed in the food industry and boasts a millenary tradition of safe use, s...

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Autores principales:	Maria Teresa Rocchetti, Pasquale Russo, Vittorio Capozzi, Djamel Drider, Giuseppe Spano, Daniela Fiocco
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Lactiplantibacillus plantarum</i> lactic acid bacteria probiotics antibacterial extracellular compound antiviral extracellular compound probiosis Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9612c95f4678461aa9870af36e11eacc
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spelling	oai:doaj.org-article:9612c95f4678461aa9870af36e11eacc2021-11-11T17:27:52ZBioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action10.3390/ijms2221120761422-00671661-6596https://doaj.org/article/9612c95f4678461aa9870af36e11eacc2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12076https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067<i>Lactiplantibacillus plantarum</i> (<i>L. plantarum</i>) is a well-studied and versatile species of lactobacilli. It is found in several niches, including human mucosal surfaces, and it is largely employed in the food industry and boasts a millenary tradition of safe use, sharing a long-lasting relationship with humans. <i>L. plantarum</i> is generally recognised as safe and exhibits a strong probiotic character, so that several strains are commercialised as health-promoting supplements and functional food products. For these reasons, <i>L. plantarum</i> represents a valuable model to gain insight into the nature and mechanisms of antimicrobials as key factors underlying the probiotic action of health-promoting microbes. Probiotic antimicrobials can inhibit the growth of pathogens in the gut ensuring the intestinal homeostasis and contributing to the host health. Furthermore, they may be attractive alternatives to conventional antibiotics, holding potential in several biomedical applications. The aim of this review is to investigate the most relevant papers published in the last ten years, bioprospecting the antimicrobial activity of characterised probiotic <i>L. plantarum</i> strains. Specifically, it focuses on the different chemical nature, the action spectra and the mechanisms underlying the bioactivity of their antibacterial and antiviral agents. Emerging trends in postbiotics, some in vivo applications of <i>L. plantarum</i> antimicrobials, including strengths and limitations of their therapeutic potential, are addressed and discussed.Maria Teresa RocchettiPasquale RussoVittorio CapozziDjamel DriderGiuseppe SpanoDaniela FioccoMDPI AGarticle<i>Lactiplantibacillus plantarum</i>lactic acid bacteriaprobioticsantibacterial extracellular compoundantiviral extracellular compoundprobiosisBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12076, p 12076 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Lactiplantibacillus plantarum</i> lactic acid bacteria probiotics antibacterial extracellular compound antiviral extracellular compound probiosis Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	<i>Lactiplantibacillus plantarum</i> lactic acid bacteria probiotics antibacterial extracellular compound antiviral extracellular compound probiosis Biology (General) QH301-705.5 Chemistry QD1-999 Maria Teresa Rocchetti Pasquale Russo Vittorio Capozzi Djamel Drider Giuseppe Spano Daniela Fiocco Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action
description	<i>Lactiplantibacillus plantarum</i> (<i>L. plantarum</i>) is a well-studied and versatile species of lactobacilli. It is found in several niches, including human mucosal surfaces, and it is largely employed in the food industry and boasts a millenary tradition of safe use, sharing a long-lasting relationship with humans. <i>L. plantarum</i> is generally recognised as safe and exhibits a strong probiotic character, so that several strains are commercialised as health-promoting supplements and functional food products. For these reasons, <i>L. plantarum</i> represents a valuable model to gain insight into the nature and mechanisms of antimicrobials as key factors underlying the probiotic action of health-promoting microbes. Probiotic antimicrobials can inhibit the growth of pathogens in the gut ensuring the intestinal homeostasis and contributing to the host health. Furthermore, they may be attractive alternatives to conventional antibiotics, holding potential in several biomedical applications. The aim of this review is to investigate the most relevant papers published in the last ten years, bioprospecting the antimicrobial activity of characterised probiotic <i>L. plantarum</i> strains. Specifically, it focuses on the different chemical nature, the action spectra and the mechanisms underlying the bioactivity of their antibacterial and antiviral agents. Emerging trends in postbiotics, some in vivo applications of <i>L. plantarum</i> antimicrobials, including strengths and limitations of their therapeutic potential, are addressed and discussed.
format	article
author	Maria Teresa Rocchetti Pasquale Russo Vittorio Capozzi Djamel Drider Giuseppe Spano Daniela Fiocco
author_facet	Maria Teresa Rocchetti Pasquale Russo Vittorio Capozzi Djamel Drider Giuseppe Spano Daniela Fiocco
author_sort	Maria Teresa Rocchetti
title	Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action
title_short	Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action
title_full	Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action
title_fullStr	Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action
title_full_unstemmed	Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action
title_sort	bioprospecting antimicrobials from <i>lactiplantibacillus plantarum</i>: key factors underlying its probiotic action
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9612c95f4678461aa9870af36e11eacc
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Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action

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