Value of Combining of the NLR and the Fibrinogen Level for Predicting Stroke-Associated Pneumonia

Wei Cheng,1,* Lichang Chen,1,* Huapeng Yu,1 Dongzhu Lu,1 Rong Yu,1 Jian Chen2 1Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, Peo...

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Autores principales:	Cheng W, Chen L, Yu H, Lu D, Yu R, Chen J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	stroke-associated pneumonia neutrophil-to-lymphocyte ratio fibrinogen receiver operating characteristic curve Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/96139139a255497cb4180ff746cf4aba
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spelling	oai:doaj.org-article:96139139a255497cb4180ff746cf4aba2021-12-02T15:01:00ZValue of Combining of the NLR and the Fibrinogen Level for Predicting Stroke-Associated Pneumonia1178-2021https://doaj.org/article/96139139a255497cb4180ff746cf4aba2021-05-01T00:00:00Zhttps://www.dovepress.com/value-of-combining-of-the-nlr-and-the-fibrinogen-level-for-predicting--peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Wei Cheng,1,* Lichang Chen,1,* Huapeng Yu,1 Dongzhu Lu,1 Rong Yu,1 Jian Chen2 1Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian ChenDepartment of Neurology, Zhujiang Hospital of Southern Medical University, No. 253, Industrial Avenue, Guangzhou, Guangdong, 510280, People’s Republic of ChinaTel +86 18665000975Fax +86 02062783083Email smuchenjian@163.comPurpose: To evaluate the value of the NLR (neutrophil-to-lymphocyte ratio) and the fibrinogen level in predicting stroke-associated pneumonia (SAP) in acute ischemic stroke (AIS) patients.Patients and Methods: In total, we enrolled 734 medical-ward patients with AIS in this retrospective study. Patients were divided into SAP (n=52) and non-SAP (n=682) groups according to the diagnostic criteria of SAP. Binary logistic regression analysis was used to analyze the relationship between the NLR, serum fibrinogen concentration and SAP. Receiver operating characteristic (ROC) curves were generated to identify the optimal cutoff points and assess the diagnostic value of the NLR, serum fibrinogen and the combination of NLR and fibrinogen in predicting SAP.Results: SAP occurred in 52 (7.08%) patients among the enrolled AIS patients. Binary logistic regression analysis showed that the NLR (odds ratio [OR]: 2.802, 95% confidence interval [CI]: 1.302– 6.032, P=0.008) and serum fibrinogen concentration (OR: 7.850, 95% CI: 3.636– 16.949, P=0.000) were independently associated with a higher risk of SAP incidence after adjusting for age, sex, ASPECT score, atrial fibrillation, nasogastric tube feeding, LDL-C and TC, temperature at admission and mechanical ventilation. The optimal cutoff points of the NLR and serum fibrinogen to distinguish SAP among AIS patients were 3.603 (AUC, 0.690; NPV, 95.78; PPV, 19.01) and 4.595 (AUC, 0.727; NPV, 95.60; PPV, 24.49), respectively. When the combination of NLR and fibrinogen was used to predict SAP, the optimal cutoff points were > 2.436 for NLR and > 3.24 for fibrinogen (AUC, 0.758; NPV, 98.50; PPV, 11.80).Conclusion: The NLR and serum fibrinogen might have greater negative diagnostic value in predicting SAP among AIS patients. Combining the NLR and serum fibrinogen showed an increased AUC for predicting SAP among AIS patients.Keywords: stroke-associated pneumonia, neutrophil-to-lymphocyte ratio, fibrinogen, receiver operating characteristic curveCheng WChen LYu HLu DYu RChen JDove Medical Pressarticlestroke-associated pneumonianeutrophil-to-lymphocyte ratiofibrinogenreceiver operating characteristic curveNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 1697-1705 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke-associated pneumonia neutrophil-to-lymphocyte ratio fibrinogen receiver operating characteristic curve Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	stroke-associated pneumonia neutrophil-to-lymphocyte ratio fibrinogen receiver operating characteristic curve Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Cheng W Chen L Yu H Lu D Yu R Chen J Value of Combining of the NLR and the Fibrinogen Level for Predicting Stroke-Associated Pneumonia
description	Wei Cheng,1,* Lichang Chen,1,* Huapeng Yu,1 Dongzhu Lu,1 Rong Yu,1 Jian Chen2 1Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian ChenDepartment of Neurology, Zhujiang Hospital of Southern Medical University, No. 253, Industrial Avenue, Guangzhou, Guangdong, 510280, People’s Republic of ChinaTel +86 18665000975Fax +86 02062783083Email smuchenjian@163.comPurpose: To evaluate the value of the NLR (neutrophil-to-lymphocyte ratio) and the fibrinogen level in predicting stroke-associated pneumonia (SAP) in acute ischemic stroke (AIS) patients.Patients and Methods: In total, we enrolled 734 medical-ward patients with AIS in this retrospective study. Patients were divided into SAP (n=52) and non-SAP (n=682) groups according to the diagnostic criteria of SAP. Binary logistic regression analysis was used to analyze the relationship between the NLR, serum fibrinogen concentration and SAP. Receiver operating characteristic (ROC) curves were generated to identify the optimal cutoff points and assess the diagnostic value of the NLR, serum fibrinogen and the combination of NLR and fibrinogen in predicting SAP.Results: SAP occurred in 52 (7.08%) patients among the enrolled AIS patients. Binary logistic regression analysis showed that the NLR (odds ratio [OR]: 2.802, 95% confidence interval [CI]: 1.302– 6.032, P=0.008) and serum fibrinogen concentration (OR: 7.850, 95% CI: 3.636– 16.949, P=0.000) were independently associated with a higher risk of SAP incidence after adjusting for age, sex, ASPECT score, atrial fibrillation, nasogastric tube feeding, LDL-C and TC, temperature at admission and mechanical ventilation. The optimal cutoff points of the NLR and serum fibrinogen to distinguish SAP among AIS patients were 3.603 (AUC, 0.690; NPV, 95.78; PPV, 19.01) and 4.595 (AUC, 0.727; NPV, 95.60; PPV, 24.49), respectively. When the combination of NLR and fibrinogen was used to predict SAP, the optimal cutoff points were > 2.436 for NLR and > 3.24 for fibrinogen (AUC, 0.758; NPV, 98.50; PPV, 11.80).Conclusion: The NLR and serum fibrinogen might have greater negative diagnostic value in predicting SAP among AIS patients. Combining the NLR and serum fibrinogen showed an increased AUC for predicting SAP among AIS patients.Keywords: stroke-associated pneumonia, neutrophil-to-lymphocyte ratio, fibrinogen, receiver operating characteristic curve
format	article
author	Cheng W Chen L Yu H Lu D Yu R Chen J
author_facet	Cheng W Chen L Yu H Lu D Yu R Chen J
author_sort	Cheng W
title	Value of Combining of the NLR and the Fibrinogen Level for Predicting Stroke-Associated Pneumonia
title_short	Value of Combining of the NLR and the Fibrinogen Level for Predicting Stroke-Associated Pneumonia
title_full	Value of Combining of the NLR and the Fibrinogen Level for Predicting Stroke-Associated Pneumonia
title_fullStr	Value of Combining of the NLR and the Fibrinogen Level for Predicting Stroke-Associated Pneumonia
title_full_unstemmed	Value of Combining of the NLR and the Fibrinogen Level for Predicting Stroke-Associated Pneumonia
title_sort	value of combining of the nlr and the fibrinogen level for predicting stroke-associated pneumonia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/96139139a255497cb4180ff746cf4aba
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Value of Combining of the NLR and the Fibrinogen Level for Predicting Stroke-Associated Pneumonia

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