Pivotal response treatment for autism spectrum disorder: current perspectives

Jiedi Lei, Pamela Ventola Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA Abstract: Pivotal response treatment (PRT) is an evidence-based behavioral intervention based on applied behavior analysis principles aimed to improve social communication skills in i...

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Autores principales:	Lei J, Ventola P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Pivotal Response Treatment (PRT) Autism Spectrum Disorder (ASD) biomarkers neuroimaging precision medicine biological motion Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9615635e35fd41c7ad90330f613aabf5
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spelling	oai:doaj.org-article:9615635e35fd41c7ad90330f613aabf52021-12-02T04:38:12ZPivotal response treatment for autism spectrum disorder: current perspectives1178-2021https://doaj.org/article/9615635e35fd41c7ad90330f613aabf52017-06-01T00:00:00Zhttps://www.dovepress.com/pivotal-response-treatment-for-autism-spectrum-disorder-current-perspe-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jiedi Lei, Pamela Ventola Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA Abstract: Pivotal response treatment (PRT) is an evidence-based behavioral intervention based on applied behavior analysis principles aimed to improve social communication skills in individuals with autism spectrum disorder (ASD). PRT adopts a more naturalistic approach and focuses on using a number of strategies to help increase children’s motivation during intervention. Since its conceptualization, PRT has received much empirical support for eliciting therapeutic gains in greater use of functional social communication skills in individuals with ASD. Building upon the empirical evidence supporting PRT, recent advancements have increasingly turned to using interdisciplinary research integrating neuroimaging techniques and behavioral measures to help identify objective biomarkers of treatment, which have two primary purposes. First, neuroimaging results can help characterize how PRT may elicit change, and facilitate partitioning of the heterogeneous profiles of neural mechanisms underlying similar profile of behavioral changes observed over PRT. Second, neuroimaging provides an objective means to both map and track how biomarkers may serve as reliable and sensitive predictors of responder profiles to PRT, assisting clinicians to identify who will most likely benefit from PRT. Together, a better understanding of both mechanisms of change and predictors of responder profile will help PRT to serve as a more precise and targeted intervention for individuals with ASD, thus moving towards the goal of precision medicine and improving quality of care. This review focuses on the recent emerging neuroimaging evidences supporting PRT, offering current perspectives on the importance of interdisciplinary research to help clinicians better understand how PRT works and predict who will respond to PRT. Keywords: PRT, ASD, biomarkers, neuroimaging, precision medicine, biological motionLei JVentola PDove Medical PressarticlePivotal Response Treatment (PRT)Autism Spectrum Disorder (ASD)biomarkersneuroimagingprecision medicinebiological motionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1613-1626 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pivotal Response Treatment (PRT) Autism Spectrum Disorder (ASD) biomarkers neuroimaging precision medicine biological motion Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Pivotal Response Treatment (PRT) Autism Spectrum Disorder (ASD) biomarkers neuroimaging precision medicine biological motion Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lei J Ventola P Pivotal response treatment for autism spectrum disorder: current perspectives
description	Jiedi Lei, Pamela Ventola Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA Abstract: Pivotal response treatment (PRT) is an evidence-based behavioral intervention based on applied behavior analysis principles aimed to improve social communication skills in individuals with autism spectrum disorder (ASD). PRT adopts a more naturalistic approach and focuses on using a number of strategies to help increase children’s motivation during intervention. Since its conceptualization, PRT has received much empirical support for eliciting therapeutic gains in greater use of functional social communication skills in individuals with ASD. Building upon the empirical evidence supporting PRT, recent advancements have increasingly turned to using interdisciplinary research integrating neuroimaging techniques and behavioral measures to help identify objective biomarkers of treatment, which have two primary purposes. First, neuroimaging results can help characterize how PRT may elicit change, and facilitate partitioning of the heterogeneous profiles of neural mechanisms underlying similar profile of behavioral changes observed over PRT. Second, neuroimaging provides an objective means to both map and track how biomarkers may serve as reliable and sensitive predictors of responder profiles to PRT, assisting clinicians to identify who will most likely benefit from PRT. Together, a better understanding of both mechanisms of change and predictors of responder profile will help PRT to serve as a more precise and targeted intervention for individuals with ASD, thus moving towards the goal of precision medicine and improving quality of care. This review focuses on the recent emerging neuroimaging evidences supporting PRT, offering current perspectives on the importance of interdisciplinary research to help clinicians better understand how PRT works and predict who will respond to PRT. Keywords: PRT, ASD, biomarkers, neuroimaging, precision medicine, biological motion
format	article
author	Lei J Ventola P
author_facet	Lei J Ventola P
author_sort	Lei J
title	Pivotal response treatment for autism spectrum disorder: current perspectives
title_short	Pivotal response treatment for autism spectrum disorder: current perspectives
title_full	Pivotal response treatment for autism spectrum disorder: current perspectives
title_fullStr	Pivotal response treatment for autism spectrum disorder: current perspectives
title_full_unstemmed	Pivotal response treatment for autism spectrum disorder: current perspectives
title_sort	pivotal response treatment for autism spectrum disorder: current perspectives
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/9615635e35fd41c7ad90330f613aabf5
work_keys_str_mv	AT leij pivotalresponsetreatmentforautismspectrumdisordercurrentperspectives AT ventolap pivotalresponsetreatmentforautismspectrumdisordercurrentperspectives
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Pivotal response treatment for autism spectrum disorder: current perspectives

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