Recombinant human melatonin receptor MT1 isolated in mixed detergents shows pharmacology similar to that in mammalian cell membranes.

The human melatonin MT1 receptor-belonging to the large family of G protein-coupled receptors (GPCRs)-plays a key role in circadian rhythm regulation and is notably involved in sleep disorders and depression. Structural and functional information at the molecular level are highly desired for fine ch...

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Autores principales: Christel Logez, Sylvie Berger, Céline Legros, Jean-Louis Banères, William Cohen, Philippe Delagrange, Olivier Nosjean, Jean A Boutin, Gilles Ferry, Frédéric Simonin, Renaud Wagner
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/961a2e8080f24c94a99bea2e9fb8eaad
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