CORRELATION OF NEOPTERINE AND IFNγ LEVELS IN THE PATIENTS WITH EXACERBATION OF CHRONIC PERIODONTITIS AND INTOLERANCE OF DENTAL MATERIALS

Studies of potential biomarkers in periodontology are focused on analysis of oral liquid which revealed a number of potential salivary periodontitis biomarkers. The biomarkers should be simple to perform, with easily interpretable results providing relevant information from initial stages of disease...

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Autor principal:	I. Yu. Karpuk
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	neopterine chronic periodontitis interferon-gamma diagnostics biomarker Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/962ae63dab634f8088efe4d84eff3a28
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spelling	oai:doaj.org-article:962ae63dab634f8088efe4d84eff3a282021-11-18T08:03:45ZCORRELATION OF NEOPTERINE AND IFNγ LEVELS IN THE PATIENTS WITH EXACERBATION OF CHRONIC PERIODONTITIS AND INTOLERANCE OF DENTAL MATERIALS1563-06252313-741X10.15789/1563-0625-2017-1-55-64https://doaj.org/article/962ae63dab634f8088efe4d84eff3a282017-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1165https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XStudies of potential biomarkers in periodontology are focused on analysis of oral liquid which revealed a number of potential salivary periodontitis biomarkers. The biomarkers should be simple to perform, with easily interpretable results providing relevant information from initial stages of disease, to measure its activity, thus reflecting the disease evolution (e.g., from gingivitis to periodontitis). However there are some more scientific, clinical and technological tasks to develop successful clinical salivary diagnostics for periodontitis treatment. The purpose of our study was to assess interrelations of IFNγ and neopterine in oral fluid of the patients with chronic generalized periodontitis (CGP), aiming for more complete understanding of periodontal disorders and at patients with an intolerance of stomatologic materials. It is shown that the average levels of neopterine in exacerbated moderate-stage CGP patients was raised before treatment to 11.6 [8.0; 15.4] ng/ml, as compared with post-treatment level of 5,5 [4,1; 7,1] ng/ml (р < 0.05) Average amount of IFNγ in oral fluid from these patients group was 6.7 [5.0; 8.7] pg/ml before treatment, as compared to 5.5 [3.5; 7.1] pg/ml after treatment (no significant difference). Neopterine level in patients with exacerbated severe CGP before treatment was even higher than in patients of moderate/severe group, with an average of 8.2 [6.0; 9.9] ng/ml thus sufficiently exceeding post-treatment levels, i.e., 5.5 [4.1; 7.1] ng/ml (р < 0.05). A course of periodontal therapy in this group was associated with sufficient changes of IFNγ levels in oral fluid: appropriate levels before and after treatment were, respectively, 8.6 [7.3; 11.2] pg/ml, and 5.4 [4.3; 6.7] pg/ml. We have revealed that the OHI-S and SBI indexes characterizing conditions of oral cavity are interconnected with local neopterine and IFNγ levels. It is shown that an increased neopterine concentration in oral fluid and its correlation with SBI index in CGP patients is an independent biomarker of therapeutic effect. The patients with a CGP exhibited a highly significant correlation between initial levels of IFNγ and neopterine in oral fluid (R = 0.82; p = 0.0001), and after treatment (R = 0.78; p = 0.0001) in both groups of the patients.Level of a neopterin and IFNγ at patients with complaints to intolerance of dentoprosthetic materials before removal of artificial limbs and after removal of orthopedic designs authentically didn't change.I. Yu. KarpukSPb RAACIarticleneopterinechronic periodontitisinterferon-gammadiagnosticsbiomarkerImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 1, Pp 55-64 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	neopterine chronic periodontitis interferon-gamma diagnostics biomarker Immunologic diseases. Allergy RC581-607
spellingShingle	neopterine chronic periodontitis interferon-gamma diagnostics biomarker Immunologic diseases. Allergy RC581-607 I. Yu. Karpuk CORRELATION OF NEOPTERINE AND IFNγ LEVELS IN THE PATIENTS WITH EXACERBATION OF CHRONIC PERIODONTITIS AND INTOLERANCE OF DENTAL MATERIALS
description	Studies of potential biomarkers in periodontology are focused on analysis of oral liquid which revealed a number of potential salivary periodontitis biomarkers. The biomarkers should be simple to perform, with easily interpretable results providing relevant information from initial stages of disease, to measure its activity, thus reflecting the disease evolution (e.g., from gingivitis to periodontitis). However there are some more scientific, clinical and technological tasks to develop successful clinical salivary diagnostics for periodontitis treatment. The purpose of our study was to assess interrelations of IFNγ and neopterine in oral fluid of the patients with chronic generalized periodontitis (CGP), aiming for more complete understanding of periodontal disorders and at patients with an intolerance of stomatologic materials. It is shown that the average levels of neopterine in exacerbated moderate-stage CGP patients was raised before treatment to 11.6 [8.0; 15.4] ng/ml, as compared with post-treatment level of 5,5 [4,1; 7,1] ng/ml (р < 0.05) Average amount of IFNγ in oral fluid from these patients group was 6.7 [5.0; 8.7] pg/ml before treatment, as compared to 5.5 [3.5; 7.1] pg/ml after treatment (no significant difference). Neopterine level in patients with exacerbated severe CGP before treatment was even higher than in patients of moderate/severe group, with an average of 8.2 [6.0; 9.9] ng/ml thus sufficiently exceeding post-treatment levels, i.e., 5.5 [4.1; 7.1] ng/ml (р < 0.05). A course of periodontal therapy in this group was associated with sufficient changes of IFNγ levels in oral fluid: appropriate levels before and after treatment were, respectively, 8.6 [7.3; 11.2] pg/ml, and 5.4 [4.3; 6.7] pg/ml. We have revealed that the OHI-S and SBI indexes characterizing conditions of oral cavity are interconnected with local neopterine and IFNγ levels. It is shown that an increased neopterine concentration in oral fluid and its correlation with SBI index in CGP patients is an independent biomarker of therapeutic effect. The patients with a CGP exhibited a highly significant correlation between initial levels of IFNγ and neopterine in oral fluid (R = 0.82; p = 0.0001), and after treatment (R = 0.78; p = 0.0001) in both groups of the patients.Level of a neopterin and IFNγ at patients with complaints to intolerance of dentoprosthetic materials before removal of artificial limbs and after removal of orthopedic designs authentically didn't change.
format	article
author	I. Yu. Karpuk
author_facet	I. Yu. Karpuk
author_sort	I. Yu. Karpuk
title	CORRELATION OF NEOPTERINE AND IFNγ LEVELS IN THE PATIENTS WITH EXACERBATION OF CHRONIC PERIODONTITIS AND INTOLERANCE OF DENTAL MATERIALS
title_short	CORRELATION OF NEOPTERINE AND IFNγ LEVELS IN THE PATIENTS WITH EXACERBATION OF CHRONIC PERIODONTITIS AND INTOLERANCE OF DENTAL MATERIALS
title_full	CORRELATION OF NEOPTERINE AND IFNγ LEVELS IN THE PATIENTS WITH EXACERBATION OF CHRONIC PERIODONTITIS AND INTOLERANCE OF DENTAL MATERIALS
title_fullStr	CORRELATION OF NEOPTERINE AND IFNγ LEVELS IN THE PATIENTS WITH EXACERBATION OF CHRONIC PERIODONTITIS AND INTOLERANCE OF DENTAL MATERIALS
title_full_unstemmed	CORRELATION OF NEOPTERINE AND IFNγ LEVELS IN THE PATIENTS WITH EXACERBATION OF CHRONIC PERIODONTITIS AND INTOLERANCE OF DENTAL MATERIALS
title_sort	correlation of neopterine and ifnγ levels in the patients with exacerbation of chronic periodontitis and intolerance of dental materials
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/962ae63dab634f8088efe4d84eff3a28
work_keys_str_mv	AT iyukarpuk correlationofneopterineandifnglevelsinthepatientswithexacerbationofchronicperiodontitisandintoleranceofdentalmaterials
_version_	1718422435000221696

CORRELATION OF NEOPTERINE AND IFNγ LEVELS IN THE PATIENTS WITH EXACERBATION OF CHRONIC PERIODONTITIS AND INTOLERANCE OF DENTAL MATERIALS

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