Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells

Living cells and tissues experience various complex modes of forces but how different force modes impact gene expression is elusive. Here authors apply forces via magnetic beads to integrins on a cell surface and observe force-mode dependent chromatin stretching and gene upregulation in cells and id...

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Autores principales:	Fuxiang Wei, Xiangyu Xu, Cunyu Zhang, Yawen Liao, Baohua Ji, Ning Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/962d1725337f4e5b8e220adf785b2708
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id	oai:doaj.org-article:962d1725337f4e5b8e220adf785b2708
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spelling	oai:doaj.org-article:962d1725337f4e5b8e220adf785b27082021-12-02T19:16:47ZStress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells10.1038/s41467-020-18584-52041-1723https://doaj.org/article/962d1725337f4e5b8e220adf785b27082020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18584-5https://doaj.org/toc/2041-1723Living cells and tissues experience various complex modes of forces but how different force modes impact gene expression is elusive. Here authors apply forces via magnetic beads to integrins on a cell surface and observe force-mode dependent chromatin stretching and gene upregulation in cells and identify underlying mechanisms.Fuxiang WeiXiangyu XuCunyu ZhangYawen LiaoBaohua JiNing WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fuxiang Wei Xiangyu Xu Cunyu Zhang Yawen Liao Baohua Ji Ning Wang Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells
description	Living cells and tissues experience various complex modes of forces but how different force modes impact gene expression is elusive. Here authors apply forces via magnetic beads to integrins on a cell surface and observe force-mode dependent chromatin stretching and gene upregulation in cells and identify underlying mechanisms.
format	article
author	Fuxiang Wei Xiangyu Xu Cunyu Zhang Yawen Liao Baohua Ji Ning Wang
author_facet	Fuxiang Wei Xiangyu Xu Cunyu Zhang Yawen Liao Baohua Ji Ning Wang
author_sort	Fuxiang Wei
title	Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells
title_short	Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells
title_full	Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells
title_fullStr	Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells
title_full_unstemmed	Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells
title_sort	stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/962d1725337f4e5b8e220adf785b2708
work_keys_str_mv	AT fuxiangwei stressfiberanisotropycontributestoforcemodedependentchromatinstretchingandgeneupregulationinlivingcells AT xiangyuxu stressfiberanisotropycontributestoforcemodedependentchromatinstretchingandgeneupregulationinlivingcells AT cunyuzhang stressfiberanisotropycontributestoforcemodedependentchromatinstretchingandgeneupregulationinlivingcells AT yawenliao stressfiberanisotropycontributestoforcemodedependentchromatinstretchingandgeneupregulationinlivingcells AT baohuaji stressfiberanisotropycontributestoforcemodedependentchromatinstretchingandgeneupregulationinlivingcells AT ningwang stressfiberanisotropycontributestoforcemodedependentchromatinstretchingandgeneupregulationinlivingcells
_version_	1718376927747637248

Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells

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