Frequency, risk factors, and outcomes of hospital readmissions of COVID-19 patients
Abstract To determine the proportion of patients with COVID-19 who were readmitted to the hospital and the most common causes and the factors associated with readmission. Multicenter nationwide cohort study in Spain. Patients included in the study were admitted to 147 hospitals from March 1 to April...
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Nature Portfolio
2021
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oai:doaj.org-article:962f9ba3c67840f490235bd10a0902e42021-12-02T16:31:58ZFrequency, risk factors, and outcomes of hospital readmissions of COVID-19 patients10.1038/s41598-021-93076-02045-2322https://doaj.org/article/962f9ba3c67840f490235bd10a0902e42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93076-0https://doaj.org/toc/2045-2322Abstract To determine the proportion of patients with COVID-19 who were readmitted to the hospital and the most common causes and the factors associated with readmission. Multicenter nationwide cohort study in Spain. Patients included in the study were admitted to 147 hospitals from March 1 to April 30, 2020. Readmission was defined as a new hospital admission during the 30 days after discharge. Emergency department visits after discharge were not considered readmission. During the study period 8392 patients were admitted to hospitals participating in the SEMI-COVID-19 network. 298 patients (4.2%) out of 7137 patients were readmitted after being discharged. 1541 (17.7%) died during the index admission and 35 died during hospital readmission (11.7%, p = 0.007). The median time from discharge to readmission was 7 days (IQR 3–15 days). The most frequent causes of hospital readmission were worsening of previous pneumonia (54%), bacterial infection (13%), venous thromboembolism (5%), and heart failure (5%). Age [odds ratio (OR): 1.02; 95% confident interval (95% CI): 1.01–1.03], age-adjusted Charlson comorbidity index score (OR: 1.13; 95% CI: 1.06–1.21), chronic obstructive pulmonary disease (OR: 1.84; 95% CI: 1.26–2.69), asthma (OR: 1.52; 95% CI: 1.04–2.22), hemoglobin level at admission (OR: 0.92; 95% CI: 0.86–0.99), ground-glass opacification at admission (OR: 0.86; 95% CI:0.76–0.98) and glucocorticoid treatment (OR: 1.29; 95% CI: 1.00–1.66) were independently associated with hospital readmission. The rate of readmission after hospital discharge for COVID-19 was low. Advanced age and comorbidity were associated with increased risk of readmission.Antonio Ramos-MartínezLina Marcela Parra-RamírezIgnacio MorrásMaría CarnevaliLorena Jiménez-IbañezManuel Rubio-RivasFrancisco ArnalichJosé Luis BeatoDaniel MongeUxua AsínCarmen SuárezSantiago Jesús FreireManuel Méndez-BailónIsabel PeralesJosé Loureiro-AmigoAna Belén Gómez-BeldaPaula María PesqueiraRicardo Gómez-HuelgasCarmen MellaLuis Felipe Díez-GarcíaJoaquim Fernández-SolaRuth González-FerrerMarina ArozaJuan Miguel Antón-SantosCarlos Lumbreras BermejoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Antonio Ramos-Martínez Lina Marcela Parra-Ramírez Ignacio Morrás María Carnevali Lorena Jiménez-Ibañez Manuel Rubio-Rivas Francisco Arnalich José Luis Beato Daniel Monge Uxua Asín Carmen Suárez Santiago Jesús Freire Manuel Méndez-Bailón Isabel Perales José Loureiro-Amigo Ana Belén Gómez-Belda Paula María Pesqueira Ricardo Gómez-Huelgas Carmen Mella Luis Felipe Díez-García Joaquim Fernández-Sola Ruth González-Ferrer Marina Aroza Juan Miguel Antón-Santos Carlos Lumbreras Bermejo Frequency, risk factors, and outcomes of hospital readmissions of COVID-19 patients |
| description |
Abstract To determine the proportion of patients with COVID-19 who were readmitted to the hospital and the most common causes and the factors associated with readmission. Multicenter nationwide cohort study in Spain. Patients included in the study were admitted to 147 hospitals from March 1 to April 30, 2020. Readmission was defined as a new hospital admission during the 30 days after discharge. Emergency department visits after discharge were not considered readmission. During the study period 8392 patients were admitted to hospitals participating in the SEMI-COVID-19 network. 298 patients (4.2%) out of 7137 patients were readmitted after being discharged. 1541 (17.7%) died during the index admission and 35 died during hospital readmission (11.7%, p = 0.007). The median time from discharge to readmission was 7 days (IQR 3–15 days). The most frequent causes of hospital readmission were worsening of previous pneumonia (54%), bacterial infection (13%), venous thromboembolism (5%), and heart failure (5%). Age [odds ratio (OR): 1.02; 95% confident interval (95% CI): 1.01–1.03], age-adjusted Charlson comorbidity index score (OR: 1.13; 95% CI: 1.06–1.21), chronic obstructive pulmonary disease (OR: 1.84; 95% CI: 1.26–2.69), asthma (OR: 1.52; 95% CI: 1.04–2.22), hemoglobin level at admission (OR: 0.92; 95% CI: 0.86–0.99), ground-glass opacification at admission (OR: 0.86; 95% CI:0.76–0.98) and glucocorticoid treatment (OR: 1.29; 95% CI: 1.00–1.66) were independently associated with hospital readmission. The rate of readmission after hospital discharge for COVID-19 was low. Advanced age and comorbidity were associated with increased risk of readmission. |
| format |
article |
| author |
Antonio Ramos-Martínez Lina Marcela Parra-Ramírez Ignacio Morrás María Carnevali Lorena Jiménez-Ibañez Manuel Rubio-Rivas Francisco Arnalich José Luis Beato Daniel Monge Uxua Asín Carmen Suárez Santiago Jesús Freire Manuel Méndez-Bailón Isabel Perales José Loureiro-Amigo Ana Belén Gómez-Belda Paula María Pesqueira Ricardo Gómez-Huelgas Carmen Mella Luis Felipe Díez-García Joaquim Fernández-Sola Ruth González-Ferrer Marina Aroza Juan Miguel Antón-Santos Carlos Lumbreras Bermejo |
| author_facet |
Antonio Ramos-Martínez Lina Marcela Parra-Ramírez Ignacio Morrás María Carnevali Lorena Jiménez-Ibañez Manuel Rubio-Rivas Francisco Arnalich José Luis Beato Daniel Monge Uxua Asín Carmen Suárez Santiago Jesús Freire Manuel Méndez-Bailón Isabel Perales José Loureiro-Amigo Ana Belén Gómez-Belda Paula María Pesqueira Ricardo Gómez-Huelgas Carmen Mella Luis Felipe Díez-García Joaquim Fernández-Sola Ruth González-Ferrer Marina Aroza Juan Miguel Antón-Santos Carlos Lumbreras Bermejo |
| author_sort |
Antonio Ramos-Martínez |
| title |
Frequency, risk factors, and outcomes of hospital readmissions of COVID-19 patients |
| title_short |
Frequency, risk factors, and outcomes of hospital readmissions of COVID-19 patients |
| title_full |
Frequency, risk factors, and outcomes of hospital readmissions of COVID-19 patients |
| title_fullStr |
Frequency, risk factors, and outcomes of hospital readmissions of COVID-19 patients |
| title_full_unstemmed |
Frequency, risk factors, and outcomes of hospital readmissions of COVID-19 patients |
| title_sort |
frequency, risk factors, and outcomes of hospital readmissions of covid-19 patients |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/962f9ba3c67840f490235bd10a0902e4 |
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