Circulating CTRP7 Is a Potential Predictor for Metabolic Syndrome
BackgroundPrevious animal studies have revealed that CTRP7 is related to energy metabolism. However, little is known regarding the relationship between CTRP7 and metabolic diseases in humans. Hence, this study was designed to explore the association between CTRP7 and MetS through a cross-sectional s...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:963473104aca45c1b392a2cc79f4d6322021-11-11T08:22:02ZCirculating CTRP7 Is a Potential Predictor for Metabolic Syndrome1664-239210.3389/fendo.2021.774309https://doaj.org/article/963473104aca45c1b392a2cc79f4d6322021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.774309/fullhttps://doaj.org/toc/1664-2392BackgroundPrevious animal studies have revealed that CTRP7 is related to energy metabolism. However, little is known regarding the relationship between CTRP7 and metabolic diseases in humans. Hence, this study was designed to explore the association between CTRP7 and MetS through a cross-sectional study and multiple intervention studies.MethodsA total of 624 individuals were enrolled in this study. The levels of CTRP7 and APN were determined by ELISA kit. HEC, OGTT and lipid infusion were performed in heathy individuals to investigate the association of CTRP7 and glucose, insulin and FFA. Bioinformatics analysis was then undertaken to identify genes and signaling pathways associated with CTRP7. The relationship between CTRP7 with MetS components was also evaluated.ResultsIn MetS patients, serum CTRP7 concentrations were significantly higher than in healthy controls, and was positively correlated with WC, BP, FBG, 2h-BG and TG, but negatively correlated with HDL-C and APN. Multivariate logistic regression analysis uncovered that CTRP7 was strongly correlated with the occurrence of MetS. In addition, circulating levels of CTRP7 in patients with two or more MetS components were higher than those with one MetS component. In the intervention studies, OGTTs resulted in a significant reduction in serum CTRP7 concentration. However, the increase in insulin levels caused by EHC and the increase of FFA caused by lipid-infusion led to the significant increase of serum CTRP7 concentration. Meanwhile, bioinformatics analysis revealed that CTRP7 was strongly associated with metabolism-related genes and signal pathways, which further illustrate the association of CTRP7 with whole-body metabolism.ConclusionsSerum CTRP7 is increased in MetS patients, which may be a biomarker related to metabolic diseases.Clinical Trial Registration NumberChiCTR2000032878Wenjing HuBin ZhanQinge LiGangyi YangMengliu YangMinghong TanShan GengHua LiuChen ChenDongfang LiuLing LiFrontiers Media S.A.articleCTRP7MetSinsulin resistanceinterventional testsBioinformaticsDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
| institution |
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DOAJ |
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EN |
| topic |
CTRP7 MetS insulin resistance interventional tests Bioinformatics Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
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CTRP7 MetS insulin resistance interventional tests Bioinformatics Diseases of the endocrine glands. Clinical endocrinology RC648-665 Wenjing Hu Bin Zhan Qinge Li Gangyi Yang Mengliu Yang Minghong Tan Shan Geng Hua Liu Chen Chen Dongfang Liu Ling Li Circulating CTRP7 Is a Potential Predictor for Metabolic Syndrome |
| description |
BackgroundPrevious animal studies have revealed that CTRP7 is related to energy metabolism. However, little is known regarding the relationship between CTRP7 and metabolic diseases in humans. Hence, this study was designed to explore the association between CTRP7 and MetS through a cross-sectional study and multiple intervention studies.MethodsA total of 624 individuals were enrolled in this study. The levels of CTRP7 and APN were determined by ELISA kit. HEC, OGTT and lipid infusion were performed in heathy individuals to investigate the association of CTRP7 and glucose, insulin and FFA. Bioinformatics analysis was then undertaken to identify genes and signaling pathways associated with CTRP7. The relationship between CTRP7 with MetS components was also evaluated.ResultsIn MetS patients, serum CTRP7 concentrations were significantly higher than in healthy controls, and was positively correlated with WC, BP, FBG, 2h-BG and TG, but negatively correlated with HDL-C and APN. Multivariate logistic regression analysis uncovered that CTRP7 was strongly correlated with the occurrence of MetS. In addition, circulating levels of CTRP7 in patients with two or more MetS components were higher than those with one MetS component. In the intervention studies, OGTTs resulted in a significant reduction in serum CTRP7 concentration. However, the increase in insulin levels caused by EHC and the increase of FFA caused by lipid-infusion led to the significant increase of serum CTRP7 concentration. Meanwhile, bioinformatics analysis revealed that CTRP7 was strongly associated with metabolism-related genes and signal pathways, which further illustrate the association of CTRP7 with whole-body metabolism.ConclusionsSerum CTRP7 is increased in MetS patients, which may be a biomarker related to metabolic diseases.Clinical Trial Registration NumberChiCTR2000032878 |
| format |
article |
| author |
Wenjing Hu Bin Zhan Qinge Li Gangyi Yang Mengliu Yang Minghong Tan Shan Geng Hua Liu Chen Chen Dongfang Liu Ling Li |
| author_facet |
Wenjing Hu Bin Zhan Qinge Li Gangyi Yang Mengliu Yang Minghong Tan Shan Geng Hua Liu Chen Chen Dongfang Liu Ling Li |
| author_sort |
Wenjing Hu |
| title |
Circulating CTRP7 Is a Potential Predictor for Metabolic Syndrome |
| title_short |
Circulating CTRP7 Is a Potential Predictor for Metabolic Syndrome |
| title_full |
Circulating CTRP7 Is a Potential Predictor for Metabolic Syndrome |
| title_fullStr |
Circulating CTRP7 Is a Potential Predictor for Metabolic Syndrome |
| title_full_unstemmed |
Circulating CTRP7 Is a Potential Predictor for Metabolic Syndrome |
| title_sort |
circulating ctrp7 is a potential predictor for metabolic syndrome |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/963473104aca45c1b392a2cc79f4d632 |
| work_keys_str_mv |
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