Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour

Abstract Differences in gut microbiota composition have been observed in patients with major depressive disorder (MDD) compared to healthy individuals. Here, we investigated if faecal microbiota transplantation (FMT) from patients with MDD into rats could induce a depressive-like phenotype. We perfo...

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Autores principales:	Julie Kristine Knudsen, Thomas Yssing Michaelsen, Caspar Bundgaard-Nielsen, René Ernst Nielsen, Simon Hjerrild, Peter Leutscher, Gregers Wegener, Suzette Sørensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/963a1d1277cb4b60a37e14b6f6692306
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spelling	oai:doaj.org-article:963a1d1277cb4b60a37e14b6f66923062021-11-14T12:22:36ZFaecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour10.1038/s41598-021-01248-92045-2322https://doaj.org/article/963a1d1277cb4b60a37e14b6f66923062021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01248-9https://doaj.org/toc/2045-2322Abstract Differences in gut microbiota composition have been observed in patients with major depressive disorder (MDD) compared to healthy individuals. Here, we investigated if faecal microbiota transplantation (FMT) from patients with MDD into rats could induce a depressive-like phenotype. We performed FMT from patients with MDD (FMT-MDD) and healthy individuals (FMT-Healthy) into male Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats and assessed depressive-like behaviour. No behavioural differences were observed in the FSL rats. In FRL rats, the FMT-Healthy group displayed significantly less depressive-like behaviour than the FMT-MDD group. However, there was no difference in behaviour between FMT-MDD FRL rats and negative controls, indicating that FMT-Healthy FRL rats received beneficial bacteria. We additionally found different taxa between the FMT-MDD and the FMT-Healthy FRL rats, which could be traced to the donors. Four taxa, three belonging to the family Ruminococcaceae and the genus Lachnospira, were significantly elevated in relative abundance in FMT-MDD rats, while the genus Coprococcus was depleted. In this study, the FMT-MDD group was different from the FMT-Healthy group based on behaviour and intestinal taxa.Julie Kristine KnudsenThomas Yssing MichaelsenCaspar Bundgaard-NielsenRené Ernst NielsenSimon HjerrildPeter LeutscherGregers WegenerSuzette SørensenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julie Kristine Knudsen Thomas Yssing Michaelsen Caspar Bundgaard-Nielsen René Ernst Nielsen Simon Hjerrild Peter Leutscher Gregers Wegener Suzette Sørensen Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour
description	Abstract Differences in gut microbiota composition have been observed in patients with major depressive disorder (MDD) compared to healthy individuals. Here, we investigated if faecal microbiota transplantation (FMT) from patients with MDD into rats could induce a depressive-like phenotype. We performed FMT from patients with MDD (FMT-MDD) and healthy individuals (FMT-Healthy) into male Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats and assessed depressive-like behaviour. No behavioural differences were observed in the FSL rats. In FRL rats, the FMT-Healthy group displayed significantly less depressive-like behaviour than the FMT-MDD group. However, there was no difference in behaviour between FMT-MDD FRL rats and negative controls, indicating that FMT-Healthy FRL rats received beneficial bacteria. We additionally found different taxa between the FMT-MDD and the FMT-Healthy FRL rats, which could be traced to the donors. Four taxa, three belonging to the family Ruminococcaceae and the genus Lachnospira, were significantly elevated in relative abundance in FMT-MDD rats, while the genus Coprococcus was depleted. In this study, the FMT-MDD group was different from the FMT-Healthy group based on behaviour and intestinal taxa.
format	article
author	Julie Kristine Knudsen Thomas Yssing Michaelsen Caspar Bundgaard-Nielsen René Ernst Nielsen Simon Hjerrild Peter Leutscher Gregers Wegener Suzette Sørensen
author_facet	Julie Kristine Knudsen Thomas Yssing Michaelsen Caspar Bundgaard-Nielsen René Ernst Nielsen Simon Hjerrild Peter Leutscher Gregers Wegener Suzette Sørensen
author_sort	Julie Kristine Knudsen
title	Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour
title_short	Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour
title_full	Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour
title_fullStr	Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour
title_full_unstemmed	Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour
title_sort	faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/963a1d1277cb4b60a37e14b6f6692306
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Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour

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