Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome.

Evaluation of pain-induced changes in functional connectivity was performed in pediatric complex regional pain syndrome (CRPS) patients. High field functional magnetic resonance imaging was done in the symptomatic painful state and at follow up in the asymptomatic pain free/recovered state. Two type...

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Autores principales:	Clas Linnman, Lino Becerra, Alyssa Lebel, Charles Berde, P Ellen Grant, David Borsook
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/963a6c1d76744629a222b9565238b9e9
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spelling	oai:doaj.org-article:963a6c1d76744629a222b9565238b9e92021-11-18T07:53:03ZTransient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome.1932-620310.1371/journal.pone.0057205https://doaj.org/article/963a6c1d76744629a222b9565238b9e92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23526938/?tool=EBIhttps://doaj.org/toc/1932-6203Evaluation of pain-induced changes in functional connectivity was performed in pediatric complex regional pain syndrome (CRPS) patients. High field functional magnetic resonance imaging was done in the symptomatic painful state and at follow up in the asymptomatic pain free/recovered state. Two types of connectivity alterations were defined: (1) Transient increases in functional connectivity that identified regions with increased cold-induced functional connectivity in the affected limb vs. unaffected limb in the CRPS state, but with normalized connectivity patterns in the recovered state; and (2) Persistent increases in functional connectivity that identified regions with increased cold-induced functional connectivity in the affected limb as compared to the unaffected limb that persisted also in the recovered state (recovered affected limb versus recovered unaffected limb). The data support the notion that even after symptomatic recovery, alterations in brain systems persist, particularly in amygdala and basal ganglia systems. Connectivity analysis may provide a measure of temporal normalization of different circuits/regions when evaluating therapeutic interventions for this condition. The results add emphasis to the importance of early recognition and management in improving outcome of pediatric CRPS.Clas LinnmanLino BecerraAlyssa LebelCharles BerdeP Ellen GrantDavid BorsookPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e57205 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Clas Linnman Lino Becerra Alyssa Lebel Charles Berde P Ellen Grant David Borsook Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome.
description	Evaluation of pain-induced changes in functional connectivity was performed in pediatric complex regional pain syndrome (CRPS) patients. High field functional magnetic resonance imaging was done in the symptomatic painful state and at follow up in the asymptomatic pain free/recovered state. Two types of connectivity alterations were defined: (1) Transient increases in functional connectivity that identified regions with increased cold-induced functional connectivity in the affected limb vs. unaffected limb in the CRPS state, but with normalized connectivity patterns in the recovered state; and (2) Persistent increases in functional connectivity that identified regions with increased cold-induced functional connectivity in the affected limb as compared to the unaffected limb that persisted also in the recovered state (recovered affected limb versus recovered unaffected limb). The data support the notion that even after symptomatic recovery, alterations in brain systems persist, particularly in amygdala and basal ganglia systems. Connectivity analysis may provide a measure of temporal normalization of different circuits/regions when evaluating therapeutic interventions for this condition. The results add emphasis to the importance of early recognition and management in improving outcome of pediatric CRPS.
format	article
author	Clas Linnman Lino Becerra Alyssa Lebel Charles Berde P Ellen Grant David Borsook
author_facet	Clas Linnman Lino Becerra Alyssa Lebel Charles Berde P Ellen Grant David Borsook
author_sort	Clas Linnman
title	Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome.
title_short	Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome.
title_full	Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome.
title_fullStr	Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome.
title_full_unstemmed	Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome.
title_sort	transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/963a6c1d76744629a222b9565238b9e9
work_keys_str_mv	AT claslinnman transientandpersistentpaininducedconnectivityalterationsinpediatriccomplexregionalpainsyndrome AT linobecerra transientandpersistentpaininducedconnectivityalterationsinpediatriccomplexregionalpainsyndrome AT alyssalebel transientandpersistentpaininducedconnectivityalterationsinpediatriccomplexregionalpainsyndrome AT charlesberde transientandpersistentpaininducedconnectivityalterationsinpediatriccomplexregionalpainsyndrome AT pellengrant transientandpersistentpaininducedconnectivityalterationsinpediatriccomplexregionalpainsyndrome AT davidborsook transientandpersistentpaininducedconnectivityalterationsinpediatriccomplexregionalpainsyndrome
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Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome.

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