BRN2 is a non-canonical melanoma tumor-suppressor
The transcription factor BRN2 regulates melanoma migration and invasion, but its role during melanoma initiation is unclear. Here the authors show that BRN2 is a haplo-insufficient tumour suppressor that positively regulates PTEN expression and in the context of BRAF mutation and heterozygous PTEN,...
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Nature Portfolio
2021
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oai:doaj.org-article:963d00b98bc54a4ea97659da7f5bc5532021-12-02T17:40:27ZBRN2 is a non-canonical melanoma tumor-suppressor10.1038/s41467-021-23973-52041-1723https://doaj.org/article/963d00b98bc54a4ea97659da7f5bc5532021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23973-5https://doaj.org/toc/2041-1723The transcription factor BRN2 regulates melanoma migration and invasion, but its role during melanoma initiation is unclear. Here the authors show that BRN2 is a haplo-insufficient tumour suppressor that positively regulates PTEN expression and in the context of BRAF mutation and heterozygous PTEN, BRN2 loss promotes melanoma initiation and progression.Michael HammPierre SohierValérie PetitJérémy H. RaymondVéronique DelmasMadeleine Le CozFranck GesbertColin KennyZackie AktaryMarie PouteauxFlorian RambowAlain SarasinNisamanee CharoenchonAlfonso BellacosaLuis Sanchez-del-CampoLaura MosteoMartin LaussDies MeijerEirikur SteingrimssonGöran B. JönssonRobert A. CornellIrwin DavidsonColin R. GodingLionel LarueNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Michael Hamm Pierre Sohier Valérie Petit Jérémy H. Raymond Véronique Delmas Madeleine Le Coz Franck Gesbert Colin Kenny Zackie Aktary Marie Pouteaux Florian Rambow Alain Sarasin Nisamanee Charoenchon Alfonso Bellacosa Luis Sanchez-del-Campo Laura Mosteo Martin Lauss Dies Meijer Eirikur Steingrimsson Göran B. Jönsson Robert A. Cornell Irwin Davidson Colin R. Goding Lionel Larue BRN2 is a non-canonical melanoma tumor-suppressor |
| description |
The transcription factor BRN2 regulates melanoma migration and invasion, but its role during melanoma initiation is unclear. Here the authors show that BRN2 is a haplo-insufficient tumour suppressor that positively regulates PTEN expression and in the context of BRAF mutation and heterozygous PTEN, BRN2 loss promotes melanoma initiation and progression. |
| format |
article |
| author |
Michael Hamm Pierre Sohier Valérie Petit Jérémy H. Raymond Véronique Delmas Madeleine Le Coz Franck Gesbert Colin Kenny Zackie Aktary Marie Pouteaux Florian Rambow Alain Sarasin Nisamanee Charoenchon Alfonso Bellacosa Luis Sanchez-del-Campo Laura Mosteo Martin Lauss Dies Meijer Eirikur Steingrimsson Göran B. Jönsson Robert A. Cornell Irwin Davidson Colin R. Goding Lionel Larue |
| author_facet |
Michael Hamm Pierre Sohier Valérie Petit Jérémy H. Raymond Véronique Delmas Madeleine Le Coz Franck Gesbert Colin Kenny Zackie Aktary Marie Pouteaux Florian Rambow Alain Sarasin Nisamanee Charoenchon Alfonso Bellacosa Luis Sanchez-del-Campo Laura Mosteo Martin Lauss Dies Meijer Eirikur Steingrimsson Göran B. Jönsson Robert A. Cornell Irwin Davidson Colin R. Goding Lionel Larue |
| author_sort |
Michael Hamm |
| title |
BRN2 is a non-canonical melanoma tumor-suppressor |
| title_short |
BRN2 is a non-canonical melanoma tumor-suppressor |
| title_full |
BRN2 is a non-canonical melanoma tumor-suppressor |
| title_fullStr |
BRN2 is a non-canonical melanoma tumor-suppressor |
| title_full_unstemmed |
BRN2 is a non-canonical melanoma tumor-suppressor |
| title_sort |
brn2 is a non-canonical melanoma tumor-suppressor |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/963d00b98bc54a4ea97659da7f5bc553 |
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