Differences in digit ratios between gay men who prefer receptive versus insertive sex roles indicate a role for prenatal androgen

Abstract Among non-human mammals, exposure to androgens during critical periods of development leads to gynephilia (attraction to females), whereas the absence or low levels of prenatal androgens leads to androphilia (attraction to males). However, in humans, retrospective markers of prenatal androg...

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Autores principales:	Ashlyn Swift-Gallant, Victor Di Rita, Christina A. Major, Christopher J. Breedlove, Cynthia L. Jordan, S. Marc Breedlove
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/963e760a9dec413e9e3eb3f3d678c3e9
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spelling	oai:doaj.org-article:963e760a9dec413e9e3eb3f3d678c3e92021-12-02T14:27:56ZDifferences in digit ratios between gay men who prefer receptive versus insertive sex roles indicate a role for prenatal androgen10.1038/s41598-021-87338-02045-2322https://doaj.org/article/963e760a9dec413e9e3eb3f3d678c3e92021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87338-0https://doaj.org/toc/2045-2322Abstract Among non-human mammals, exposure to androgens during critical periods of development leads to gynephilia (attraction to females), whereas the absence or low levels of prenatal androgens leads to androphilia (attraction to males). However, in humans, retrospective markers of prenatal androgens have only been associated with gynephilia among women, but not with androphilia among men. Here, we asked whether an indirect indication of prenatal androgen exposure, 2D:4D, differs between subsets of gay men delineated by anal sex role (ASR). ASR was used as a proxy for subgroups because ASR groups tend to differ in other measures affected by brain sexual differentiation, such as gender conformity. First, we replicated the finding that gay men with a receptive ASR preference (bottoms) report greater gender nonconformity (GNC) compared to gay men with an insertive ASR preference (tops). We then found that Tops have a lower (male-typical) average right-hand digit ratio than Bottoms, and that among all gay men the right-hand 2D:4D correlated with GNC, indicating that a higher (female-typical) 2D:4D is associated with increased GNC. Differences were found between non-exclusive and exclusive same-sex attraction and GNC, and ASR group differences on digit ratios do not reach significance when all non-heterosexual men are included in the analyses, suggesting greater heterogeneity in the development of non-exclusive same-sex sexual orientations. Overall, results support a role for prenatal androgens, as approximated by digit ratios, in influencing the sexual orientation and GNC of a subset of gay men.Ashlyn Swift-GallantVictor Di RitaChristina A. MajorChristopher J. BreedloveCynthia L. JordanS. Marc BreedloveNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ashlyn Swift-Gallant Victor Di Rita Christina A. Major Christopher J. Breedlove Cynthia L. Jordan S. Marc Breedlove Differences in digit ratios between gay men who prefer receptive versus insertive sex roles indicate a role for prenatal androgen
description	Abstract Among non-human mammals, exposure to androgens during critical periods of development leads to gynephilia (attraction to females), whereas the absence or low levels of prenatal androgens leads to androphilia (attraction to males). However, in humans, retrospective markers of prenatal androgens have only been associated with gynephilia among women, but not with androphilia among men. Here, we asked whether an indirect indication of prenatal androgen exposure, 2D:4D, differs between subsets of gay men delineated by anal sex role (ASR). ASR was used as a proxy for subgroups because ASR groups tend to differ in other measures affected by brain sexual differentiation, such as gender conformity. First, we replicated the finding that gay men with a receptive ASR preference (bottoms) report greater gender nonconformity (GNC) compared to gay men with an insertive ASR preference (tops). We then found that Tops have a lower (male-typical) average right-hand digit ratio than Bottoms, and that among all gay men the right-hand 2D:4D correlated with GNC, indicating that a higher (female-typical) 2D:4D is associated with increased GNC. Differences were found between non-exclusive and exclusive same-sex attraction and GNC, and ASR group differences on digit ratios do not reach significance when all non-heterosexual men are included in the analyses, suggesting greater heterogeneity in the development of non-exclusive same-sex sexual orientations. Overall, results support a role for prenatal androgens, as approximated by digit ratios, in influencing the sexual orientation and GNC of a subset of gay men.
format	article
author	Ashlyn Swift-Gallant Victor Di Rita Christina A. Major Christopher J. Breedlove Cynthia L. Jordan S. Marc Breedlove
author_facet	Ashlyn Swift-Gallant Victor Di Rita Christina A. Major Christopher J. Breedlove Cynthia L. Jordan S. Marc Breedlove
author_sort	Ashlyn Swift-Gallant
title	Differences in digit ratios between gay men who prefer receptive versus insertive sex roles indicate a role for prenatal androgen
title_short	Differences in digit ratios between gay men who prefer receptive versus insertive sex roles indicate a role for prenatal androgen
title_full	Differences in digit ratios between gay men who prefer receptive versus insertive sex roles indicate a role for prenatal androgen
title_fullStr	Differences in digit ratios between gay men who prefer receptive versus insertive sex roles indicate a role for prenatal androgen
title_full_unstemmed	Differences in digit ratios between gay men who prefer receptive versus insertive sex roles indicate a role for prenatal androgen
title_sort	differences in digit ratios between gay men who prefer receptive versus insertive sex roles indicate a role for prenatal androgen
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/963e760a9dec413e9e3eb3f3d678c3e9
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Differences in digit ratios between gay men who prefer receptive versus insertive sex roles indicate a role for prenatal androgen

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