Metabolomic credentialing of murine carcinogen-induced urothelial cancer
Abstract Bladder cancer (BCa) is the most common malignancy of the urinary system with increasing incidence, mortality, and limited treatment options. Therefore, it is imperative to validate preclinical models that faithfully represent BCa cellular, molecular, and metabolic heterogeneity to develop...
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Nature Portfolio
2021
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oai:doaj.org-article:9642edddfaa74bfa8f06a1f1d2f9bd3a2021-11-14T12:18:10ZMetabolomic credentialing of murine carcinogen-induced urothelial cancer10.1038/s41598-021-99746-32045-2322https://doaj.org/article/9642edddfaa74bfa8f06a1f1d2f9bd3a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99746-3https://doaj.org/toc/2045-2322Abstract Bladder cancer (BCa) is the most common malignancy of the urinary system with increasing incidence, mortality, and limited treatment options. Therefore, it is imperative to validate preclinical models that faithfully represent BCa cellular, molecular, and metabolic heterogeneity to develop new therapeutics. We performed metabolomic profiling of premalignant and non-muscle invasive bladder cancer (NMIBC) that ensued in the chemical carcinogenesis N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) mouse model. We identified the enriched metabolic signatures that associate with premalignant and NMIBC. We found that enrichment of lipid metabolism is the forerunner of carcinogen-induced premalignant and NMIBC lesions. Cross-species analysis revealed the prognostic value of the enzymes associated with carcinogen-induced enriched metabolic in human disease. To date, this is the first study describing the global metabolomic profiles associated with early premalignant and NMIBC and provide evidence that these metabolomic signatures can be used for prognostication of human disease.Hesham AfifyAlia GhoneumSameh AlmousaAmmar Yasser AbdulfattahBailey WarrenKendall LangstenDaniela GonzalezRandy CasalsManish BharadwajSteven KridelNeveen SaidNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
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Medicine R Science Q Hesham Afify Alia Ghoneum Sameh Almousa Ammar Yasser Abdulfattah Bailey Warren Kendall Langsten Daniela Gonzalez Randy Casals Manish Bharadwaj Steven Kridel Neveen Said Metabolomic credentialing of murine carcinogen-induced urothelial cancer |
| description |
Abstract Bladder cancer (BCa) is the most common malignancy of the urinary system with increasing incidence, mortality, and limited treatment options. Therefore, it is imperative to validate preclinical models that faithfully represent BCa cellular, molecular, and metabolic heterogeneity to develop new therapeutics. We performed metabolomic profiling of premalignant and non-muscle invasive bladder cancer (NMIBC) that ensued in the chemical carcinogenesis N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) mouse model. We identified the enriched metabolic signatures that associate with premalignant and NMIBC. We found that enrichment of lipid metabolism is the forerunner of carcinogen-induced premalignant and NMIBC lesions. Cross-species analysis revealed the prognostic value of the enzymes associated with carcinogen-induced enriched metabolic in human disease. To date, this is the first study describing the global metabolomic profiles associated with early premalignant and NMIBC and provide evidence that these metabolomic signatures can be used for prognostication of human disease. |
| format |
article |
| author |
Hesham Afify Alia Ghoneum Sameh Almousa Ammar Yasser Abdulfattah Bailey Warren Kendall Langsten Daniela Gonzalez Randy Casals Manish Bharadwaj Steven Kridel Neveen Said |
| author_facet |
Hesham Afify Alia Ghoneum Sameh Almousa Ammar Yasser Abdulfattah Bailey Warren Kendall Langsten Daniela Gonzalez Randy Casals Manish Bharadwaj Steven Kridel Neveen Said |
| author_sort |
Hesham Afify |
| title |
Metabolomic credentialing of murine carcinogen-induced urothelial cancer |
| title_short |
Metabolomic credentialing of murine carcinogen-induced urothelial cancer |
| title_full |
Metabolomic credentialing of murine carcinogen-induced urothelial cancer |
| title_fullStr |
Metabolomic credentialing of murine carcinogen-induced urothelial cancer |
| title_full_unstemmed |
Metabolomic credentialing of murine carcinogen-induced urothelial cancer |
| title_sort |
metabolomic credentialing of murine carcinogen-induced urothelial cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/9642edddfaa74bfa8f06a1f1d2f9bd3a |
| work_keys_str_mv |
AT heshamafify metabolomiccredentialingofmurinecarcinogeninducedurothelialcancer AT aliaghoneum metabolomiccredentialingofmurinecarcinogeninducedurothelialcancer AT samehalmousa metabolomiccredentialingofmurinecarcinogeninducedurothelialcancer AT ammaryasserabdulfattah metabolomiccredentialingofmurinecarcinogeninducedurothelialcancer AT baileywarren metabolomiccredentialingofmurinecarcinogeninducedurothelialcancer AT kendalllangsten metabolomiccredentialingofmurinecarcinogeninducedurothelialcancer AT danielagonzalez metabolomiccredentialingofmurinecarcinogeninducedurothelialcancer AT randycasals metabolomiccredentialingofmurinecarcinogeninducedurothelialcancer AT manishbharadwaj metabolomiccredentialingofmurinecarcinogeninducedurothelialcancer AT stevenkridel metabolomiccredentialingofmurinecarcinogeninducedurothelialcancer AT neveensaid metabolomiccredentialingofmurinecarcinogeninducedurothelialcancer |
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1718429302845865984 |