The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease

The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease

Parkinson’s disease (PD) is characterized by neurodegeneration associated with loss of dopaminergic (DA) neurons and deposition of Lewy bodies. Here, Wang et al. use co-expression network analysis to pinpoint disease pathways and propose reduced expression of STMN2 as a cause of presynaptic function...

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Autores principales: Qian Wang, Yuanxi Zhang, Minghui Wang, Won-Min Song, Qi Shen, Andrew McKenzie, Insup Choi, Xianxiao Zhou, Ping-Yue Pan, Zhenyu Yue, Bin Zhang
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/96444c6437f24e2ca9c8556203493dfa
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spelling oai:doaj.org-article:96444c6437f24e2ca9c8556203493dfa2021-12-02T14:39:41ZThe landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease10.1038/s41467-019-13144-y2041-1723https://doaj.org/article/96444c6437f24e2ca9c8556203493dfa2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13144-yhttps://doaj.org/toc/2041-1723Parkinson’s disease (PD) is characterized by neurodegeneration associated with loss of dopaminergic (DA) neurons and deposition of Lewy bodies. Here, Wang et al. use co-expression network analysis to pinpoint disease pathways and propose reduced expression of STMN2 as a cause of presynaptic function loss in PD.Qian WangYuanxi ZhangMinghui WangWon-Min SongQi ShenAndrew McKenzieInsup ChoiXianxiao ZhouPing-Yue PanZhenyu YueBin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qian Wang
Yuanxi Zhang
Minghui Wang
Won-Min Song
Qi Shen
Andrew McKenzie
Insup Choi
Xianxiao Zhou
Ping-Yue Pan
Zhenyu Yue
Bin Zhang
The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease
description Parkinson’s disease (PD) is characterized by neurodegeneration associated with loss of dopaminergic (DA) neurons and deposition of Lewy bodies. Here, Wang et al. use co-expression network analysis to pinpoint disease pathways and propose reduced expression of STMN2 as a cause of presynaptic function loss in PD.
format article
author Qian Wang
Yuanxi Zhang
Minghui Wang
Won-Min Song
Qi Shen
Andrew McKenzie
Insup Choi
Xianxiao Zhou
Ping-Yue Pan
Zhenyu Yue
Bin Zhang
author_facet Qian Wang
Yuanxi Zhang
Minghui Wang
Won-Min Song
Qi Shen
Andrew McKenzie
Insup Choi
Xianxiao Zhou
Ping-Yue Pan
Zhenyu Yue
Bin Zhang
author_sort Qian Wang
title The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease
title_short The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease
title_full The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease
title_fullStr The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease
title_full_unstemmed The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease
title_sort landscape of multiscale transcriptomic networks and key regulators in parkinson’s disease
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/96444c6437f24e2ca9c8556203493dfa
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