Changes in waist circumference and mortality in middle-aged men and women.

<h4>Background</h4>Waist circumference (WC) adjusted for body mass index (BMI) is positively associated with mortality, but the association with changes in WC is less clear. We investigated the association between changes in WC and mortality in middle-aged men and women, and evaluated th...

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Autores principales:	Tina Landsvig Berentzen, Marianne Uhre Jakobsen, Jytte Halkjaer, Anne Tjønneland, Kim Overvad, Thorkild I A Sørensen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/96477d80751f4f2f8733995eb2c242bf
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spelling	oai:doaj.org-article:96477d80751f4f2f8733995eb2c242bf2021-11-18T07:03:48ZChanges in waist circumference and mortality in middle-aged men and women.1932-620310.1371/journal.pone.0013097https://doaj.org/article/96477d80751f4f2f8733995eb2c242bf2010-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20927346/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Waist circumference (WC) adjusted for body mass index (BMI) is positively associated with mortality, but the association with changes in WC is less clear. We investigated the association between changes in WC and mortality in middle-aged men and women, and evaluated the influence from concurrent changes in BMI.<h4>Methodology/principal findings</h4>Data on 26,625 healthy men and women from the Danish Diet, Cancer and Health study was analyzed. WC and BMI were assessed in 1993-97 and in 1999-02. Information on mortality was obtained by linkage to the Danish central Person Register. Hazard ratios (HR) were estimated with Cox regression models. During 6.7 years of follow-up, 568 and 361 deaths occurred among men and women, respectively. Changes in WC were positively associated with mortality (HR per 5 cm for the sexes combined = 1.09 (1.02 : 1.16) with adjustment for covariates, baseline WC, BMI and changes in BMI), whereas changes in BMI were inversely associated with mortality (HR per kg/m2 for the sexes combined = 0.91 (0.86, 0.97) with adjustment for covariates, baseline WC, BMI and changes in WC). Associations between changes in WC and mortality were not notably different in sub-groups stratified according to changes in BMI, baseline WC or when smokers or deaths occurring within the first years of follow-up were excluded.<h4>Conclusions/significance</h4>Changes in WC were positively associated with mortality in healthy middle-aged men and women throughout the range of concurrent changes in BMI. These findings suggest a need for development of prevention and treatment strategies targeted against redistribution of fat mass towards the abdominal region.Tina Landsvig BerentzenMarianne Uhre JakobsenJytte HalkjaerAnne TjønnelandKim OvervadThorkild I A SørensenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 9 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tina Landsvig Berentzen Marianne Uhre Jakobsen Jytte Halkjaer Anne Tjønneland Kim Overvad Thorkild I A Sørensen Changes in waist circumference and mortality in middle-aged men and women.
description	<h4>Background</h4>Waist circumference (WC) adjusted for body mass index (BMI) is positively associated with mortality, but the association with changes in WC is less clear. We investigated the association between changes in WC and mortality in middle-aged men and women, and evaluated the influence from concurrent changes in BMI.<h4>Methodology/principal findings</h4>Data on 26,625 healthy men and women from the Danish Diet, Cancer and Health study was analyzed. WC and BMI were assessed in 1993-97 and in 1999-02. Information on mortality was obtained by linkage to the Danish central Person Register. Hazard ratios (HR) were estimated with Cox regression models. During 6.7 years of follow-up, 568 and 361 deaths occurred among men and women, respectively. Changes in WC were positively associated with mortality (HR per 5 cm for the sexes combined = 1.09 (1.02 : 1.16) with adjustment for covariates, baseline WC, BMI and changes in BMI), whereas changes in BMI were inversely associated with mortality (HR per kg/m2 for the sexes combined = 0.91 (0.86, 0.97) with adjustment for covariates, baseline WC, BMI and changes in WC). Associations between changes in WC and mortality were not notably different in sub-groups stratified according to changes in BMI, baseline WC or when smokers or deaths occurring within the first years of follow-up were excluded.<h4>Conclusions/significance</h4>Changes in WC were positively associated with mortality in healthy middle-aged men and women throughout the range of concurrent changes in BMI. These findings suggest a need for development of prevention and treatment strategies targeted against redistribution of fat mass towards the abdominal region.
format	article
author	Tina Landsvig Berentzen Marianne Uhre Jakobsen Jytte Halkjaer Anne Tjønneland Kim Overvad Thorkild I A Sørensen
author_facet	Tina Landsvig Berentzen Marianne Uhre Jakobsen Jytte Halkjaer Anne Tjønneland Kim Overvad Thorkild I A Sørensen
author_sort	Tina Landsvig Berentzen
title	Changes in waist circumference and mortality in middle-aged men and women.
title_short	Changes in waist circumference and mortality in middle-aged men and women.
title_full	Changes in waist circumference and mortality in middle-aged men and women.
title_fullStr	Changes in waist circumference and mortality in middle-aged men and women.
title_full_unstemmed	Changes in waist circumference and mortality in middle-aged men and women.
title_sort	changes in waist circumference and mortality in middle-aged men and women.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/96477d80751f4f2f8733995eb2c242bf
work_keys_str_mv	AT tinalandsvigberentzen changesinwaistcircumferenceandmortalityinmiddleagedmenandwomen AT marianneuhrejakobsen changesinwaistcircumferenceandmortalityinmiddleagedmenandwomen AT jyttehalkjaer changesinwaistcircumferenceandmortalityinmiddleagedmenandwomen AT annetjønneland changesinwaistcircumferenceandmortalityinmiddleagedmenandwomen AT kimovervad changesinwaistcircumferenceandmortalityinmiddleagedmenandwomen AT thorkildiasørensen changesinwaistcircumferenceandmortalityinmiddleagedmenandwomen
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Changes in waist circumference and mortality in middle-aged men and women.

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