PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia

Abstract The gene of protein interacting with C kinase 1 alpha (PICK1) has been implicated in schizophrenia, nevertheless, conflicting results existed. However, its role in cognitive function remains unclear. Besides, cognitive deficits impair the long-term outcome. We explored whether the polymorph...

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Autores principales:	Yi-Ting Chen, Chieh-Hsin Lin, Chiung-Hsien Huang, Wen-Miin Liang, Hsien-Yuan Lane
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/964abec06b184cfe943e07f64cde3bce
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spelling	oai:doaj.org-article:964abec06b184cfe943e07f64cde3bce2021-12-02T12:31:46ZPICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia10.1038/s41598-017-01975-y2045-2322https://doaj.org/article/964abec06b184cfe943e07f64cde3bce2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01975-yhttps://doaj.org/toc/2045-2322Abstract The gene of protein interacting with C kinase 1 alpha (PICK1) has been implicated in schizophrenia, nevertheless, conflicting results existed. However, its role in cognitive function remains unclear. Besides, cognitive deficits impair the long-term outcome. We explored whether the polymorphisms of PICK1 (rs2076369, rs3952) affected cognitive functions in schizophrenic patients. We analyzed 302 patients and tested the differences of cognitive functions, clinical symptoms between genetic groups. We also used general linear model to analyze the effect of PICK1 genetic polymorphisms on cognitive functions. After adjustment for gender, age, education, the patients with rs2076369 G/T genotype showed better performance than T/T homozygotes in the summary score, global composite score, neurocognitive composite score, category fluency subtest, WAIS-III-Digit Symbol Coding subtest, working memory, WMS-III-Spatial Span (backward) subtest, MSCEIT-managing emotions branch (p = 0.038, 0.025, 0.046, 0.036, 0.025, 0.027, 0.035, 0.028, respectively). G/G homozygotes performed better than T/T in category fluency subtest (p = 0.049). A/A homozygotes of rs3952 performed better than G/G in trail making A subtest (p = 0.048). To our knowledge, this is the first study to indicate that PICK1 polymorphisms may associate with cognitive functions in schizophrenic patients. Further replication studies in healthy controls or other ethnic groups are warranted.Yi-Ting ChenChieh-Hsin LinChiung-Hsien HuangWen-Miin LiangHsien-Yuan LaneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-Ting Chen Chieh-Hsin Lin Chiung-Hsien Huang Wen-Miin Liang Hsien-Yuan Lane PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia
description	Abstract The gene of protein interacting with C kinase 1 alpha (PICK1) has been implicated in schizophrenia, nevertheless, conflicting results existed. However, its role in cognitive function remains unclear. Besides, cognitive deficits impair the long-term outcome. We explored whether the polymorphisms of PICK1 (rs2076369, rs3952) affected cognitive functions in schizophrenic patients. We analyzed 302 patients and tested the differences of cognitive functions, clinical symptoms between genetic groups. We also used general linear model to analyze the effect of PICK1 genetic polymorphisms on cognitive functions. After adjustment for gender, age, education, the patients with rs2076369 G/T genotype showed better performance than T/T homozygotes in the summary score, global composite score, neurocognitive composite score, category fluency subtest, WAIS-III-Digit Symbol Coding subtest, working memory, WMS-III-Spatial Span (backward) subtest, MSCEIT-managing emotions branch (p = 0.038, 0.025, 0.046, 0.036, 0.025, 0.027, 0.035, 0.028, respectively). G/G homozygotes performed better than T/T in category fluency subtest (p = 0.049). A/A homozygotes of rs3952 performed better than G/G in trail making A subtest (p = 0.048). To our knowledge, this is the first study to indicate that PICK1 polymorphisms may associate with cognitive functions in schizophrenic patients. Further replication studies in healthy controls or other ethnic groups are warranted.
format	article
author	Yi-Ting Chen Chieh-Hsin Lin Chiung-Hsien Huang Wen-Miin Liang Hsien-Yuan Lane
author_facet	Yi-Ting Chen Chieh-Hsin Lin Chiung-Hsien Huang Wen-Miin Liang Hsien-Yuan Lane
author_sort	Yi-Ting Chen
title	PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia
title_short	PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia
title_full	PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia
title_fullStr	PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia
title_full_unstemmed	PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia
title_sort	pick1 genetic variation and cognitive function in patients with schizophrenia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/964abec06b184cfe943e07f64cde3bce
work_keys_str_mv	AT yitingchen pick1geneticvariationandcognitivefunctioninpatientswithschizophrenia AT chiehhsinlin pick1geneticvariationandcognitivefunctioninpatientswithschizophrenia AT chiunghsienhuang pick1geneticvariationandcognitivefunctioninpatientswithschizophrenia AT wenmiinliang pick1geneticvariationandcognitivefunctioninpatientswithschizophrenia AT hsienyuanlane pick1geneticvariationandcognitivefunctioninpatientswithschizophrenia
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PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia

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