Increased mean platelet volume in patients with panic disorder

Mehmet Hanifi Kokacya,1 Umit Sertan Copoglu,1 Yüksel Kivrak,2 Mustafa Ari,1 Musa Sahpolat,1 Kemal Türker Ulutas3 1Department of Psychiatry, Faculty of Medicine, Mustafa Kemal University, Hatay, 2Department of Psychiatry, Faculty of Medicine, Kafkas University, Kars, 3Department of...

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Autores principales:	Kokacya MH, Copoglu US, Kivrak Y, Ari M, Sahpolat M, Ulutas KT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/964af09558a949b0b077a019a7e9aa5e
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spelling	oai:doaj.org-article:964af09558a949b0b077a019a7e9aa5e2021-12-02T06:18:01ZIncreased mean platelet volume in patients with panic disorder1178-2021https://doaj.org/article/964af09558a949b0b077a019a7e9aa5e2015-10-01T00:00:00Zhttps://www.dovepress.com/increased-mean-platelet-volume-in-patients-with-panic-disorder-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Mehmet Hanifi Kokacya,1 Umit Sertan Copoglu,1 Yüksel Kivrak,2 Mustafa Ari,1 Musa Sahpolat,1 Kemal Türker Ulutas3 1Department of Psychiatry, Faculty of Medicine, Mustafa Kemal University, Hatay, 2Department of Psychiatry, Faculty of Medicine, Kafkas University, Kars, 3Department of Biochemistry, Kadirli State Hospital, Osmaniye, Turkey Objective: The relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD).Methods: Sixty-one drug-free patients, aged 18–65 years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age- and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject.Results: The MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI.Conclusion: Alterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients. Keywords: mean platelet volume, panic disorder, anxietyKokacya MHCopoglu USKivrak YAri MSahpolat MUlutas KTDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2629-2633 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kokacya MH Copoglu US Kivrak Y Ari M Sahpolat M Ulutas KT Increased mean platelet volume in patients with panic disorder
description	Mehmet Hanifi Kokacya,1 Umit Sertan Copoglu,1 Yüksel Kivrak,2 Mustafa Ari,1 Musa Sahpolat,1 Kemal Türker Ulutas3 1Department of Psychiatry, Faculty of Medicine, Mustafa Kemal University, Hatay, 2Department of Psychiatry, Faculty of Medicine, Kafkas University, Kars, 3Department of Biochemistry, Kadirli State Hospital, Osmaniye, Turkey Objective: The relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD).Methods: Sixty-one drug-free patients, aged 18–65 years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age- and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject.Results: The MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI.Conclusion: Alterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients. Keywords: mean platelet volume, panic disorder, anxiety
format	article
author	Kokacya MH Copoglu US Kivrak Y Ari M Sahpolat M Ulutas KT
author_facet	Kokacya MH Copoglu US Kivrak Y Ari M Sahpolat M Ulutas KT
author_sort	Kokacya MH
title	Increased mean platelet volume in patients with panic disorder
title_short	Increased mean platelet volume in patients with panic disorder
title_full	Increased mean platelet volume in patients with panic disorder
title_fullStr	Increased mean platelet volume in patients with panic disorder
title_full_unstemmed	Increased mean platelet volume in patients with panic disorder
title_sort	increased mean platelet volume in patients with panic disorder
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/964af09558a949b0b077a019a7e9aa5e
work_keys_str_mv	AT kokacyamh increasedmeanplateletvolumeinpatientswithpanicdisorder AT copogluus increasedmeanplateletvolumeinpatientswithpanicdisorder AT kivraky increasedmeanplateletvolumeinpatientswithpanicdisorder AT arim increasedmeanplateletvolumeinpatientswithpanicdisorder AT sahpolatm increasedmeanplateletvolumeinpatientswithpanicdisorder AT ulutaskt increasedmeanplateletvolumeinpatientswithpanicdisorder
_version_	1718400003508011008

Increased mean platelet volume in patients with panic disorder

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