Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice.

Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice.

<h4>Objective</h4>Determination of the in vivo significance of LDL receptor-related protein 1 (LRP1) dysfunction on lipid metabolism and atherosclerosis development in absence of its main ligand apoE.<h4>Methods and results</h4>LRP1 knock-in mice carrying an inactivating muta...

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Autores principales: Philip L S M Gordts, Alexander Bartelt, Stefan K Nilsson, Wim Annaert, Christina Christoffersen, Lars Bo Nielsen, Joerg Heeren, Anton J M Roebroek
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/964b5f858a5f4d03bd8bfaeec9dd7143
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