The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome

The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome

The inactive X chromosome (Xi) has an atypical structure, with global loss of TADs, A/B compartments and formation of mega-domains. Here the authors show that the non-canonical SMC family protein, SmcHD1, important for developmental gene silencing on Xi, antagonises TAD formation and compartmentaliz...

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Autores principales: Michal R. Gdula, Tatyana B. Nesterova, Greta Pintacuda, Jonathan Godwin, Ye Zhan, Hakan Ozadam, Michael McClellan, Daniella Moralli, Felix Krueger, Catherine M. Green, Wolf Reik, Skirmantas Kriaucionis, Edith Heard, Job Dekker, Neil Brockdorff
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Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/9651dc44fd574c31817692a66b9637db
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spelling oai:doaj.org-article:9651dc44fd574c31817692a66b9637db2021-12-02T15:35:48ZThe non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome10.1038/s41467-018-07907-22041-1723https://doaj.org/article/9651dc44fd574c31817692a66b9637db2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07907-2https://doaj.org/toc/2041-1723The inactive X chromosome (Xi) has an atypical structure, with global loss of TADs, A/B compartments and formation of mega-domains. Here the authors show that the non-canonical SMC family protein, SmcHD1, important for developmental gene silencing on Xi, antagonises TAD formation and compartmentalization on the Xi in a transcription independent way.Michal R. GdulaTatyana B. NesterovaGreta PintacudaJonathan GodwinYe ZhanHakan OzadamMichael McClellanDaniella MoralliFelix KruegerCatherine M. GreenWolf ReikSkirmantas KriaucionisEdith HeardJob DekkerNeil BrockdorffNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Michal R. Gdula
Tatyana B. Nesterova
Greta Pintacuda
Jonathan Godwin
Ye Zhan
Hakan Ozadam
Michael McClellan
Daniella Moralli
Felix Krueger
Catherine M. Green
Wolf Reik
Skirmantas Kriaucionis
Edith Heard
Job Dekker
Neil Brockdorff
The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome
description The inactive X chromosome (Xi) has an atypical structure, with global loss of TADs, A/B compartments and formation of mega-domains. Here the authors show that the non-canonical SMC family protein, SmcHD1, important for developmental gene silencing on Xi, antagonises TAD formation and compartmentalization on the Xi in a transcription independent way.
format article
author Michal R. Gdula
Tatyana B. Nesterova
Greta Pintacuda
Jonathan Godwin
Ye Zhan
Hakan Ozadam
Michael McClellan
Daniella Moralli
Felix Krueger
Catherine M. Green
Wolf Reik
Skirmantas Kriaucionis
Edith Heard
Job Dekker
Neil Brockdorff
author_facet Michal R. Gdula
Tatyana B. Nesterova
Greta Pintacuda
Jonathan Godwin
Ye Zhan
Hakan Ozadam
Michael McClellan
Daniella Moralli
Felix Krueger
Catherine M. Green
Wolf Reik
Skirmantas Kriaucionis
Edith Heard
Job Dekker
Neil Brockdorff
author_sort Michal R. Gdula
title The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome
title_short The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome
title_full The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome
title_fullStr The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome
title_full_unstemmed The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome
title_sort non-canonical smc protein smchd1 antagonises tad formation and compartmentalisation on the inactive x chromosome
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/9651dc44fd574c31817692a66b9637db
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