Pilot study quantifying muscle glycosaminoglycan using bi-exponential T1ρ mapping in patients with muscle stiffness after stroke

Abstract Post stroke muscle stiffness is a common problem, which left untreated can lead to disabling muscle contractures. The purpose of this pilot study was to evaluate the feasibility of bi-exponential T1ρ mapping in patients with arm muscle stiffness after stroke and its ability to measure treat...

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Autores principales:	Rajiv G. Menon, Preeti Raghavan, Ravinder R. Regatte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9652661f91174c13bc9e5d6b8046cfee
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spelling	oai:doaj.org-article:9652661f91174c13bc9e5d6b8046cfee2021-12-02T15:39:41ZPilot study quantifying muscle glycosaminoglycan using bi-exponential T1ρ mapping in patients with muscle stiffness after stroke10.1038/s41598-021-93304-72045-2322https://doaj.org/article/9652661f91174c13bc9e5d6b8046cfee2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93304-7https://doaj.org/toc/2045-2322Abstract Post stroke muscle stiffness is a common problem, which left untreated can lead to disabling muscle contractures. The purpose of this pilot study was to evaluate the feasibility of bi-exponential T1ρ mapping in patients with arm muscle stiffness after stroke and its ability to measure treatment related changes in muscle glycosaminoglycans (GAGs). Five patients with muscle stiffness after stroke and 5 healthy controls were recruited for imaging of the upper arm with 3D-T1ρ mapping. Patients were scanned before and after treatment with hyaluronidase injections, whereas the controls were scanned once. Wilcoxon Mann–Whitney tests compared patients vs. controls and patients pre-treatment vs. post-treatment. With bi-exponential modeling, the long component, T1ρl was significantly longer in the patients (biceps P = 0.01; triceps P = 0.004) compared to controls. There was also a significant difference in the signal fractions of the long and short components (biceps P = 0.03, triceps P = 0.04). The results suggest that muscle stiffness is characterized by increased muscle free water and GAG content. Post-treatment, the T1ρ parameters shifted toward control values. This pilot study demonstrates the application of bi-exponential T1ρ mapping as a marker for GAG content in muscle and as a potential treatment monitoring tool for patients with muscle stiffness after stroke.Rajiv G. MenonPreeti RaghavanRavinder R. RegatteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rajiv G. Menon Preeti Raghavan Ravinder R. Regatte Pilot study quantifying muscle glycosaminoglycan using bi-exponential T1ρ mapping in patients with muscle stiffness after stroke
description	Abstract Post stroke muscle stiffness is a common problem, which left untreated can lead to disabling muscle contractures. The purpose of this pilot study was to evaluate the feasibility of bi-exponential T1ρ mapping in patients with arm muscle stiffness after stroke and its ability to measure treatment related changes in muscle glycosaminoglycans (GAGs). Five patients with muscle stiffness after stroke and 5 healthy controls were recruited for imaging of the upper arm with 3D-T1ρ mapping. Patients were scanned before and after treatment with hyaluronidase injections, whereas the controls were scanned once. Wilcoxon Mann–Whitney tests compared patients vs. controls and patients pre-treatment vs. post-treatment. With bi-exponential modeling, the long component, T1ρl was significantly longer in the patients (biceps P = 0.01; triceps P = 0.004) compared to controls. There was also a significant difference in the signal fractions of the long and short components (biceps P = 0.03, triceps P = 0.04). The results suggest that muscle stiffness is characterized by increased muscle free water and GAG content. Post-treatment, the T1ρ parameters shifted toward control values. This pilot study demonstrates the application of bi-exponential T1ρ mapping as a marker for GAG content in muscle and as a potential treatment monitoring tool for patients with muscle stiffness after stroke.
format	article
author	Rajiv G. Menon Preeti Raghavan Ravinder R. Regatte
author_facet	Rajiv G. Menon Preeti Raghavan Ravinder R. Regatte
author_sort	Rajiv G. Menon
title	Pilot study quantifying muscle glycosaminoglycan using bi-exponential T1ρ mapping in patients with muscle stiffness after stroke
title_short	Pilot study quantifying muscle glycosaminoglycan using bi-exponential T1ρ mapping in patients with muscle stiffness after stroke
title_full	Pilot study quantifying muscle glycosaminoglycan using bi-exponential T1ρ mapping in patients with muscle stiffness after stroke
title_fullStr	Pilot study quantifying muscle glycosaminoglycan using bi-exponential T1ρ mapping in patients with muscle stiffness after stroke
title_full_unstemmed	Pilot study quantifying muscle glycosaminoglycan using bi-exponential T1ρ mapping in patients with muscle stiffness after stroke
title_sort	pilot study quantifying muscle glycosaminoglycan using bi-exponential t1ρ mapping in patients with muscle stiffness after stroke
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9652661f91174c13bc9e5d6b8046cfee
work_keys_str_mv	AT rajivgmenon pilotstudyquantifyingmuscleglycosaminoglycanusingbiexponentialt1rmappinginpatientswithmusclestiffnessafterstroke AT preetiraghavan pilotstudyquantifyingmuscleglycosaminoglycanusingbiexponentialt1rmappinginpatientswithmusclestiffnessafterstroke AT ravinderrregatte pilotstudyquantifyingmuscleglycosaminoglycanusingbiexponentialt1rmappinginpatientswithmusclestiffnessafterstroke
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Pilot study quantifying muscle glycosaminoglycan using bi-exponential T1ρ mapping in patients with muscle stiffness after stroke

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