mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

mTORC1 is a key mediator of drug resistance and also regulates autophagy. In this study, the authors demonstrate that cancer cells with acquired drug resistance exibit metabolic vulnerabilities mediated by high levels of mTORC1 and the consequent inhibition of autophagy.

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Autores principales:	Niklas Gremke, Pierfrancesco Polo, Aaron Dort, Jean Schneikert, Sabrina Elmshäuser, Corinna Brehm, Ursula Klingmüller, Anna Schmitt, Hans Christian Reinhardt, Oleg Timofeev, Michael Wanzel, Thorsten Stiewe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9653fbfc87624dd8b531af0c6eab20e9
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spelling	oai:doaj.org-article:9653fbfc87624dd8b531af0c6eab20e92021-12-02T18:02:24ZmTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability10.1038/s41467-020-18504-72041-1723https://doaj.org/article/9653fbfc87624dd8b531af0c6eab20e92020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18504-7https://doaj.org/toc/2041-1723mTORC1 is a key mediator of drug resistance and also regulates autophagy. In this study, the authors demonstrate that cancer cells with acquired drug resistance exibit metabolic vulnerabilities mediated by high levels of mTORC1 and the consequent inhibition of autophagy.Niklas GremkePierfrancesco PoloAaron DortJean SchneikertSabrina ElmshäuserCorinna BrehmUrsula KlingmüllerAnna SchmittHans Christian ReinhardtOleg TimofeevMichael WanzelThorsten StieweNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Niklas Gremke Pierfrancesco Polo Aaron Dort Jean Schneikert Sabrina Elmshäuser Corinna Brehm Ursula Klingmüller Anna Schmitt Hans Christian Reinhardt Oleg Timofeev Michael Wanzel Thorsten Stiewe mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
description	mTORC1 is a key mediator of drug resistance and also regulates autophagy. In this study, the authors demonstrate that cancer cells with acquired drug resistance exibit metabolic vulnerabilities mediated by high levels of mTORC1 and the consequent inhibition of autophagy.
format	article
author	Niklas Gremke Pierfrancesco Polo Aaron Dort Jean Schneikert Sabrina Elmshäuser Corinna Brehm Ursula Klingmüller Anna Schmitt Hans Christian Reinhardt Oleg Timofeev Michael Wanzel Thorsten Stiewe
author_facet	Niklas Gremke Pierfrancesco Polo Aaron Dort Jean Schneikert Sabrina Elmshäuser Corinna Brehm Ursula Klingmüller Anna Schmitt Hans Christian Reinhardt Oleg Timofeev Michael Wanzel Thorsten Stiewe
author_sort	Niklas Gremke
title	mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
title_short	mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
title_full	mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
title_fullStr	mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
title_full_unstemmed	mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
title_sort	mtor-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9653fbfc87624dd8b531af0c6eab20e9
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mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

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