Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

Endosomal sequestration of lipid-based nanoparticles is a barrier to delivery of nucleic acids. Here the authors test an array of cholesterol variants and perform in-depth investigation of nanoparticle shape, internal structure and intracellular trafficking.

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Detalles Bibliográficos
Autores principales:	Siddharth Patel, N. Ashwanikumar, Ema Robinson, Yan Xia, Cosmin Mihai, Joseph P. Griffith, Shangguo Hou, Adam A. Esposito, Tatiana Ketova, Kevin Welsher, John L. Joyal, Örn Almarsson, Gaurav Sahay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9657095ce49a4c28856fa65a8bc45d65
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spelling	oai:doaj.org-article:9657095ce49a4c28856fa65a8bc45d652021-12-02T14:42:46ZNaturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA10.1038/s41467-020-14527-22041-1723https://doaj.org/article/9657095ce49a4c28856fa65a8bc45d652020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14527-2https://doaj.org/toc/2041-1723Endosomal sequestration of lipid-based nanoparticles is a barrier to delivery of nucleic acids. Here the authors test an array of cholesterol variants and perform in-depth investigation of nanoparticle shape, internal structure and intracellular trafficking.Siddharth PatelN. AshwanikumarEma RobinsonYan XiaCosmin MihaiJoseph P. GriffithShangguo HouAdam A. EspositoTatiana KetovaKevin WelsherJohn L. JoyalÖrn AlmarssonGaurav SahayNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siddharth Patel N. Ashwanikumar Ema Robinson Yan Xia Cosmin Mihai Joseph P. Griffith Shangguo Hou Adam A. Esposito Tatiana Ketova Kevin Welsher John L. Joyal Örn Almarsson Gaurav Sahay Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
description	Endosomal sequestration of lipid-based nanoparticles is a barrier to delivery of nucleic acids. Here the authors test an array of cholesterol variants and perform in-depth investigation of nanoparticle shape, internal structure and intracellular trafficking.
format	article
author	Siddharth Patel N. Ashwanikumar Ema Robinson Yan Xia Cosmin Mihai Joseph P. Griffith Shangguo Hou Adam A. Esposito Tatiana Ketova Kevin Welsher John L. Joyal Örn Almarsson Gaurav Sahay
author_facet	Siddharth Patel N. Ashwanikumar Ema Robinson Yan Xia Cosmin Mihai Joseph P. Griffith Shangguo Hou Adam A. Esposito Tatiana Ketova Kevin Welsher John L. Joyal Örn Almarsson Gaurav Sahay
author_sort	Siddharth Patel
title	Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
title_short	Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
title_full	Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
title_fullStr	Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
title_full_unstemmed	Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
title_sort	naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mrna
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9657095ce49a4c28856fa65a8bc45d65
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Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

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