Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

Cancer subtypes may have distinct metabolic vulnerabilities that can be exploited for therapeutic interventions. Here, the authors show that in lung cancer, genetic activation of distinct oncogenic receptor tyrosine kinases results in unique metabolic liabilities and, in particular, EGFR aberrant ca...

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Autores principales:	Nan Jin, Aiwei Bi, Xiaojing Lan, Jun Xu, Xiaomin Wang, Yingluo Liu, Ting Wang, Shuai Tang, Hanlin Zeng, Ziqi Chen, Minjia Tan, Jing Ai, Hua Xie, Tao Zhang, Dandan Liu, Ruimin Huang, Yue Song, Elaine Lai-Han Leung, Xiaojun Yao, Jian Ding, Meiyu Geng, Shu-Hai Lin, Min Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9657645615f24b61be1f24096a3bc13c
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spelling	oai:doaj.org-article:9657645615f24b61be1f24096a3bc13c2021-12-02T17:01:29ZIdentification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer10.1038/s41467-019-10427-22041-1723https://doaj.org/article/9657645615f24b61be1f24096a3bc13c2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10427-2https://doaj.org/toc/2041-1723Cancer subtypes may have distinct metabolic vulnerabilities that can be exploited for therapeutic interventions. Here, the authors show that in lung cancer, genetic activation of distinct oncogenic receptor tyrosine kinases results in unique metabolic liabilities and, in particular, EGFR aberrant cancers rely on the serine biosynthetic pathway while FGFR aberrant cancers rely on glycolysis.Nan JinAiwei BiXiaojing LanJun XuXiaomin WangYingluo LiuTing WangShuai TangHanlin ZengZiqi ChenMinjia TanJing AiHua XieTao ZhangDandan LiuRuimin HuangYue SongElaine Lai-Han LeungXiaojun YaoJian DingMeiyu GengShu-Hai LinMin HuangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nan Jin Aiwei Bi Xiaojing Lan Jun Xu Xiaomin Wang Yingluo Liu Ting Wang Shuai Tang Hanlin Zeng Ziqi Chen Minjia Tan Jing Ai Hua Xie Tao Zhang Dandan Liu Ruimin Huang Yue Song Elaine Lai-Han Leung Xiaojun Yao Jian Ding Meiyu Geng Shu-Hai Lin Min Huang Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
description	Cancer subtypes may have distinct metabolic vulnerabilities that can be exploited for therapeutic interventions. Here, the authors show that in lung cancer, genetic activation of distinct oncogenic receptor tyrosine kinases results in unique metabolic liabilities and, in particular, EGFR aberrant cancers rely on the serine biosynthetic pathway while FGFR aberrant cancers rely on glycolysis.
format	article
author	Nan Jin Aiwei Bi Xiaojing Lan Jun Xu Xiaomin Wang Yingluo Liu Ting Wang Shuai Tang Hanlin Zeng Ziqi Chen Minjia Tan Jing Ai Hua Xie Tao Zhang Dandan Liu Ruimin Huang Yue Song Elaine Lai-Han Leung Xiaojun Yao Jian Ding Meiyu Geng Shu-Hai Lin Min Huang
author_facet	Nan Jin Aiwei Bi Xiaojing Lan Jun Xu Xiaomin Wang Yingluo Liu Ting Wang Shuai Tang Hanlin Zeng Ziqi Chen Minjia Tan Jing Ai Hua Xie Tao Zhang Dandan Liu Ruimin Huang Yue Song Elaine Lai-Han Leung Xiaojun Yao Jian Ding Meiyu Geng Shu-Hai Lin Min Huang
author_sort	Nan Jin
title	Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
title_short	Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
title_full	Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
title_fullStr	Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
title_full_unstemmed	Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
title_sort	identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9657645615f24b61be1f24096a3bc13c
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Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

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