p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR

The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of poly-PR/GR dipeptide repeats, which are encoded by the chromosome 9 open reading frame 72 (C9orf72) gene. Recently, it was shown that poly-PR/GR alters chromatin accessibility, w...

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Autores principales: Sinem Usluer, Emil Spreitzer, Benjamin Bourgeois, Tobias Madl
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
p53
Acceso en línea:https://doaj.org/article/965c28834c58400c9c7371f54ff27797
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