Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries

Abstract Wound healing is an important function of skin; however, after significant skin injury (burns) or in certain dermatological pathologies (chronic wounds), this important process can be deregulated or lost, resulting in severe complications. To avoid these, studies have focused on developing...

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Autores principales:	Álvaro Sierra-Sánchez, Kevin H. Kim, Gonzalo Blasco-Morente, Salvador Arias-Santiago
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/965dbd619858412c83b46f8a559f2abf
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spelling	oai:doaj.org-article:965dbd619858412c83b46f8a559f2abf2021-12-02T17:40:25ZCellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries10.1038/s41536-021-00144-02057-3995https://doaj.org/article/965dbd619858412c83b46f8a559f2abf2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00144-0https://doaj.org/toc/2057-3995Abstract Wound healing is an important function of skin; however, after significant skin injury (burns) or in certain dermatological pathologies (chronic wounds), this important process can be deregulated or lost, resulting in severe complications. To avoid these, studies have focused on developing tissue-engineered skin substitutes (TESSs), which attempt to replace and regenerate the damaged skin. Autologous cultured epithelial substitutes (CESs) constituted of keratinocytes, allogeneic cultured dermal substitutes (CDSs) composed of biomaterials and fibroblasts and autologous composite skin substitutes (CSSs) comprised of biomaterials, keratinocytes and fibroblasts, have been the most studied clinical TESSs, reporting positive results for different pathological conditions. However, researchers’ purpose is to develop TESSs that resemble in a better way the human skin and its wound healing process. For this reason, they have also evaluated at preclinical level the incorporation of other human cell types such as melanocytes, Merkel and Langerhans cells, skin stem cells (SSCs), induced pluripotent stem cells (iPSCs) or mesenchymal stem cells (MSCs). Among these, MSCs have been also reported in clinical studies with hopeful results. Future perspectives in the field of human-TESSs are focused on improving in vivo animal models, incorporating immune cells, designing specific niches inside the biomaterials to increase stem cell potential and developing three-dimensional bioprinting strategies, with the final purpose of increasing patient’s health care. In this review we summarize the use of different human cell populations for preclinical and clinical TESSs under research, remarking their strengths and limitations and discuss the future perspectives, which could be useful for wound healing purposes.Álvaro Sierra-SánchezKevin H. KimGonzalo Blasco-MorenteSalvador Arias-SantiagoNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-23 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Álvaro Sierra-Sánchez Kevin H. Kim Gonzalo Blasco-Morente Salvador Arias-Santiago Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries
description	Abstract Wound healing is an important function of skin; however, after significant skin injury (burns) or in certain dermatological pathologies (chronic wounds), this important process can be deregulated or lost, resulting in severe complications. To avoid these, studies have focused on developing tissue-engineered skin substitutes (TESSs), which attempt to replace and regenerate the damaged skin. Autologous cultured epithelial substitutes (CESs) constituted of keratinocytes, allogeneic cultured dermal substitutes (CDSs) composed of biomaterials and fibroblasts and autologous composite skin substitutes (CSSs) comprised of biomaterials, keratinocytes and fibroblasts, have been the most studied clinical TESSs, reporting positive results for different pathological conditions. However, researchers’ purpose is to develop TESSs that resemble in a better way the human skin and its wound healing process. For this reason, they have also evaluated at preclinical level the incorporation of other human cell types such as melanocytes, Merkel and Langerhans cells, skin stem cells (SSCs), induced pluripotent stem cells (iPSCs) or mesenchymal stem cells (MSCs). Among these, MSCs have been also reported in clinical studies with hopeful results. Future perspectives in the field of human-TESSs are focused on improving in vivo animal models, incorporating immune cells, designing specific niches inside the biomaterials to increase stem cell potential and developing three-dimensional bioprinting strategies, with the final purpose of increasing patient’s health care. In this review we summarize the use of different human cell populations for preclinical and clinical TESSs under research, remarking their strengths and limitations and discuss the future perspectives, which could be useful for wound healing purposes.
format	article
author	Álvaro Sierra-Sánchez Kevin H. Kim Gonzalo Blasco-Morente Salvador Arias-Santiago
author_facet	Álvaro Sierra-Sánchez Kevin H. Kim Gonzalo Blasco-Morente Salvador Arias-Santiago
author_sort	Álvaro Sierra-Sánchez
title	Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries
title_short	Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries
title_full	Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries
title_fullStr	Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries
title_full_unstemmed	Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries
title_sort	cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/965dbd619858412c83b46f8a559f2abf
work_keys_str_mv	AT alvarosierrasanchez cellularhumantissueengineeredskinsubstitutesinvestigatedfordeepanddifficulttohealinjuries AT kevinhkim cellularhumantissueengineeredskinsubstitutesinvestigatedfordeepanddifficulttohealinjuries AT gonzaloblascomorente cellularhumantissueengineeredskinsubstitutesinvestigatedfordeepanddifficulttohealinjuries AT salvadorariassantiago cellularhumantissueengineeredskinsubstitutesinvestigatedfordeepanddifficulttohealinjuries
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Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries

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