Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women

Lygia Paccini Lustosa,1 Patrícia Parreira Batista,1 Daniele Sirineu Pereira,2 Leani Souza Máximo Pereira,1 Aline Scianni,1 Giane Amorim Ribeiro-Samora1 1Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte, 2Physical Therapy Department, Universidad...

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Autores principales:	Lustosa LP, Batista PP, Pereira DS, Pereira LS, Scianni A, Ribeiro-Samora GA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	sarcopenia muscle performance inflammatory mediators aging. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/966052982c3f491b9666f2d3829e2673
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spelling	oai:doaj.org-article:966052982c3f491b9666f2d3829e26732021-12-02T03:45:36ZComparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women1178-1998https://doaj.org/article/966052982c3f491b9666f2d3829e26732017-08-01T00:00:00Zhttps://www.dovepress.com/comparison-between-parameters-of-muscle-performance-and-inflammatory-b-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Lygia Paccini Lustosa,1 Patrícia Parreira Batista,1 Daniele Sirineu Pereira,2 Leani Souza Máximo Pereira,1 Aline Scianni,1 Giane Amorim Ribeiro-Samora1 1Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte, 2Physical Therapy Department, Universidade Federal de Alfenas, Alfenas, Brazil Background: Sarcopenia is a multifactorial geriatric syndrome with complex interrelationships. Increased plasma levels of inflammatory mediators increase the catabolic stimuli of the musculature, thereby causing a decrease in mass and muscular function. Objective: The objective of this study was to compare the performance of the knee extensors test (by isokinetic dynamometer) and plasma levels of interleukin-6 (IL-6) and soluble receptors of tumor necrosis factor alpha (sTNFR1) between sarcopenics and non-sarcopenics community-dwelling elderly women residents of Brazil. Material and methods: The diagnosis of sarcopenia included measurements of body composition (by densitometry with dual energy source of X-ray), handgrip strength (by Jamar® dynamometer), and the usual gait velocity according to the recommendations of the European Working Group on Sarcopenia in Older People. In both sarcopenics and non-sarcopenics elderly women, we evaluated the muscle function by knee extensors test (using an isokinetic dynamometer Byodex System 4 Pro®) at angular speeds of 60°/s and 180°/s) and also we evaluated the plasma concentrations of IL-6 and sTNFR1. Comparisons of muscle performance between groups were carried out using mixed factorial ANOVA with post hoc Bonferroni test; sTNFR1 and IL-6 variables were analyzed by applying Mann–Whitney U test. Results: Statistical differences were observed between groups regarding muscle power (P=0.01), total work adjusted to body weight (P=0.01) at a rate of 180°/s, and plasma levels of sTNFR1 (P=0.01). Conclusion: Sarcopenic elder women showed lower performance of the lower limbs, especially at a higher speed, predisposing these older women to greater vulnerability in functional activities that require agility and postural stability. Plasma levels of sTNFR1 were higher for non-sarcopenics elderlies. However, due to the observational nature of the study, it was impossible to infer causality among the variables surveyed. Keywords: sarcopenia, muscle performance, inflammatory mediators, agingLustosa LPBatista PPPereira DSPereira LSScianni ARibeiro-Samora GADove Medical Pressarticlesarcopeniamuscle performanceinflammatory mediatorsaging.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 1183-1191 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	sarcopenia muscle performance inflammatory mediators aging. Geriatrics RC952-954.6
spellingShingle	sarcopenia muscle performance inflammatory mediators aging. Geriatrics RC952-954.6 Lustosa LP Batista PP Pereira DS Pereira LS Scianni A Ribeiro-Samora GA Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women
description	Lygia Paccini Lustosa,1 Patrícia Parreira Batista,1 Daniele Sirineu Pereira,2 Leani Souza Máximo Pereira,1 Aline Scianni,1 Giane Amorim Ribeiro-Samora1 1Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte, 2Physical Therapy Department, Universidade Federal de Alfenas, Alfenas, Brazil Background: Sarcopenia is a multifactorial geriatric syndrome with complex interrelationships. Increased plasma levels of inflammatory mediators increase the catabolic stimuli of the musculature, thereby causing a decrease in mass and muscular function. Objective: The objective of this study was to compare the performance of the knee extensors test (by isokinetic dynamometer) and plasma levels of interleukin-6 (IL-6) and soluble receptors of tumor necrosis factor alpha (sTNFR1) between sarcopenics and non-sarcopenics community-dwelling elderly women residents of Brazil. Material and methods: The diagnosis of sarcopenia included measurements of body composition (by densitometry with dual energy source of X-ray), handgrip strength (by Jamar® dynamometer), and the usual gait velocity according to the recommendations of the European Working Group on Sarcopenia in Older People. In both sarcopenics and non-sarcopenics elderly women, we evaluated the muscle function by knee extensors test (using an isokinetic dynamometer Byodex System 4 Pro®) at angular speeds of 60°/s and 180°/s) and also we evaluated the plasma concentrations of IL-6 and sTNFR1. Comparisons of muscle performance between groups were carried out using mixed factorial ANOVA with post hoc Bonferroni test; sTNFR1 and IL-6 variables were analyzed by applying Mann–Whitney U test. Results: Statistical differences were observed between groups regarding muscle power (P=0.01), total work adjusted to body weight (P=0.01) at a rate of 180°/s, and plasma levels of sTNFR1 (P=0.01). Conclusion: Sarcopenic elder women showed lower performance of the lower limbs, especially at a higher speed, predisposing these older women to greater vulnerability in functional activities that require agility and postural stability. Plasma levels of sTNFR1 were higher for non-sarcopenics elderlies. However, due to the observational nature of the study, it was impossible to infer causality among the variables surveyed. Keywords: sarcopenia, muscle performance, inflammatory mediators, aging
format	article
author	Lustosa LP Batista PP Pereira DS Pereira LS Scianni A Ribeiro-Samora GA
author_facet	Lustosa LP Batista PP Pereira DS Pereira LS Scianni A Ribeiro-Samora GA
author_sort	Lustosa LP
title	Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women
title_short	Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women
title_full	Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women
title_fullStr	Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women
title_full_unstemmed	Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women
title_sort	comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/966052982c3f491b9666f2d3829e2673
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Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women

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