Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery

Ai-Zheng Chen,1–3 Lin-Qing Chen,1 Shi-Bin Wang,1–3 Ya-Qiong Wang,1 Jun-Zhe Zha1 1College of Chemical Engineering, 2Institute of Pharmaceutical Engineering, 3Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, People’s Republic of China Abstra...

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Autores principales:	Chen AZ, Chen LQ, Wang SB, Wang YQ, Zha JZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/96612a45ece94225a7ec69e6e0268b42
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spelling	oai:doaj.org-article:96612a45ece94225a7ec69e6e0268b422021-12-02T06:31:49ZStudy of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery1178-2013https://doaj.org/article/96612a45ece94225a7ec69e6e0268b422015-07-01T00:00:00Zhttp://www.dovepress.com/study-of-magnetic-silk-fibroin-nanoparticles-for-massage-like-transder-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ai-Zheng Chen,1–3 Lin-Qing Chen,1 Shi-Bin Wang,1–3 Ya-Qiong Wang,1 Jun-Zhe Zha1 1College of Chemical Engineering, 2Institute of Pharmaceutical Engineering, 3Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, People’s Republic of China Abstract: A synergistic approach by the combination of magnetic nanoparticles with an alternating magnetic field for transdermal drug delivery was investigated. Methotrexate-loaded silk fibroin magnetic nanoparticles were prepared using suspension-enhanced dispersion by supercritical CO2. The physiochemical properties of the magnetic nanoparticles were characterized. In vitro studies on drug permeation across skin were performed under different magnetic fields in comparison with passive diffusion. The permeation flux enhancement factor was found to increase under a stationary magnetic field, while an alternating magnetic field enhanced drug permeation more effectively; the combination of stationary and alternating magnetic fields, which has a massage-like effect on the skin, achieved the best result. The mechanistic studies using attenuated total reflection Fourier-transform infrared spectroscopy demonstrate that an alternating magnetic field can change the ordered structure of the stratum corneum lipid bilayers from the gel to the lipid-crystalline state, which can increase the fluidity of the stratum corneum lipids, thus enhancing skin penetration. Compared with the other groups, the fluorescence signal with a bigger area detected in deeper regions of the skin also reveals that the simulated massage could enhance the drug permeation across the skin by increasing the follicular transport. The combination of magnetic nanoparticles with stationary/alternating magnetic fields has potential for effective massage-like transdermal drug delivery. Keywords: magnetic nanoparticles, magnetophoresis, supercritical fluid, alternating magnetic field, methotrexateChen AZChen LQWang SBWang YQZha JZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4639-4651 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chen AZ Chen LQ Wang SB Wang YQ Zha JZ Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery
description	Ai-Zheng Chen,1–3 Lin-Qing Chen,1 Shi-Bin Wang,1–3 Ya-Qiong Wang,1 Jun-Zhe Zha1 1College of Chemical Engineering, 2Institute of Pharmaceutical Engineering, 3Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, People’s Republic of China Abstract: A synergistic approach by the combination of magnetic nanoparticles with an alternating magnetic field for transdermal drug delivery was investigated. Methotrexate-loaded silk fibroin magnetic nanoparticles were prepared using suspension-enhanced dispersion by supercritical CO2. The physiochemical properties of the magnetic nanoparticles were characterized. In vitro studies on drug permeation across skin were performed under different magnetic fields in comparison with passive diffusion. The permeation flux enhancement factor was found to increase under a stationary magnetic field, while an alternating magnetic field enhanced drug permeation more effectively; the combination of stationary and alternating magnetic fields, which has a massage-like effect on the skin, achieved the best result. The mechanistic studies using attenuated total reflection Fourier-transform infrared spectroscopy demonstrate that an alternating magnetic field can change the ordered structure of the stratum corneum lipid bilayers from the gel to the lipid-crystalline state, which can increase the fluidity of the stratum corneum lipids, thus enhancing skin penetration. Compared with the other groups, the fluorescence signal with a bigger area detected in deeper regions of the skin also reveals that the simulated massage could enhance the drug permeation across the skin by increasing the follicular transport. The combination of magnetic nanoparticles with stationary/alternating magnetic fields has potential for effective massage-like transdermal drug delivery. Keywords: magnetic nanoparticles, magnetophoresis, supercritical fluid, alternating magnetic field, methotrexate
format	article
author	Chen AZ Chen LQ Wang SB Wang YQ Zha JZ
author_facet	Chen AZ Chen LQ Wang SB Wang YQ Zha JZ
author_sort	Chen AZ
title	Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery
title_short	Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery
title_full	Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery
title_fullStr	Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery
title_full_unstemmed	Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery
title_sort	study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/96612a45ece94225a7ec69e6e0268b42
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Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery

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