Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis

Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis

Esophageal squamous-cell carcinomas (ESCC) have poor prognosis, and detailed molecular profiles are necessary to identify prognostic markers. Here the authors analyse 60 ESCC patient samples using scRNA-seq, TCR-seq and genomics; they find mucosal immunity markers associated with survival and immuno...

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Autores principales: Xiannian Zhang, Linna Peng, Yingying Luo, Shaosen Zhang, Yang Pu, Yamei Chen, Wenjia Guo, Jiacheng Yao, Mingming Shao, Wenyi Fan, Qionghua Cui, Yiyi Xi, Yanxia Sun, Xiangjie Niu, Xuan Zhao, Liping Chen, Yuqian Wang, Yachen Liu, Xinyu Yang, Chengcheng Wang, Ce Zhong, Wen Tan, Jianbin Wang, Chen Wu, Dongxin Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/966baaf37bd24053a182f83c179aec72
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spelling oai:doaj.org-article:966baaf37bd24053a182f83c179aec722021-12-02T17:19:39ZDissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis10.1038/s41467-021-25539-x2041-1723https://doaj.org/article/966baaf37bd24053a182f83c179aec722021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25539-xhttps://doaj.org/toc/2041-1723Esophageal squamous-cell carcinomas (ESCC) have poor prognosis, and detailed molecular profiles are necessary to identify prognostic markers. Here the authors analyse 60 ESCC patient samples using scRNA-seq, TCR-seq and genomics; they find mucosal immunity markers associated with survival and immunosuppressive microenvironments.Xiannian ZhangLinna PengYingying LuoShaosen ZhangYang PuYamei ChenWenjia GuoJiacheng YaoMingming ShaoWenyi FanQionghua CuiYiyi XiYanxia SunXiangjie NiuXuan ZhaoLiping ChenYuqian WangYachen LiuXinyu YangChengcheng WangCe ZhongWen TanJianbin WangChen WuDongxin LinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiannian Zhang
Linna Peng
Yingying Luo
Shaosen Zhang
Yang Pu
Yamei Chen
Wenjia Guo
Jiacheng Yao
Mingming Shao
Wenyi Fan
Qionghua Cui
Yiyi Xi
Yanxia Sun
Xiangjie Niu
Xuan Zhao
Liping Chen
Yuqian Wang
Yachen Liu
Xinyu Yang
Chengcheng Wang
Ce Zhong
Wen Tan
Jianbin Wang
Chen Wu
Dongxin Lin
Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis
description Esophageal squamous-cell carcinomas (ESCC) have poor prognosis, and detailed molecular profiles are necessary to identify prognostic markers. Here the authors analyse 60 ESCC patient samples using scRNA-seq, TCR-seq and genomics; they find mucosal immunity markers associated with survival and immunosuppressive microenvironments.
format article
author Xiannian Zhang
Linna Peng
Yingying Luo
Shaosen Zhang
Yang Pu
Yamei Chen
Wenjia Guo
Jiacheng Yao
Mingming Shao
Wenyi Fan
Qionghua Cui
Yiyi Xi
Yanxia Sun
Xiangjie Niu
Xuan Zhao
Liping Chen
Yuqian Wang
Yachen Liu
Xinyu Yang
Chengcheng Wang
Ce Zhong
Wen Tan
Jianbin Wang
Chen Wu
Dongxin Lin
author_facet Xiannian Zhang
Linna Peng
Yingying Luo
Shaosen Zhang
Yang Pu
Yamei Chen
Wenjia Guo
Jiacheng Yao
Mingming Shao
Wenyi Fan
Qionghua Cui
Yiyi Xi
Yanxia Sun
Xiangjie Niu
Xuan Zhao
Liping Chen
Yuqian Wang
Yachen Liu
Xinyu Yang
Chengcheng Wang
Ce Zhong
Wen Tan
Jianbin Wang
Chen Wu
Dongxin Lin
author_sort Xiannian Zhang
title Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis
title_short Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis
title_full Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis
title_fullStr Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis
title_full_unstemmed Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis
title_sort dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/966baaf37bd24053a182f83c179aec72
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