Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3

Lysyl hydroxylase 3 (LH3) catalyzes collagen lysine hydroxylation and their subsequent O-linked glycosylation. Here the authors provide mechanistic insights into the lysyl hydroxylase and glycosyltransferase activities of LH3 by determining the crystal structures of full-length human LH3 bound to co...

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Autores principales:	Luigi Scietti, Antonella Chiapparino, Francesca De Giorgi, Marco Fumagalli, Lela Khoriauli, Solomon Nergadze, Shibom Basu, Vincent Olieric, Lucia Cucca, Blerida Banushi, Antonella Profumo, Elena Giulotto, Paul Gissen, Federico Forneris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9671310693c340349b00e760061a12e1
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spelling	oai:doaj.org-article:9671310693c340349b00e760061a12e12021-12-02T17:31:12ZMolecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH310.1038/s41467-018-05631-52041-1723https://doaj.org/article/9671310693c340349b00e760061a12e12018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05631-5https://doaj.org/toc/2041-1723Lysyl hydroxylase 3 (LH3) catalyzes collagen lysine hydroxylation and their subsequent O-linked glycosylation. Here the authors provide mechanistic insights into the lysyl hydroxylase and glycosyltransferase activities of LH3 by determining the crystal structures of full-length human LH3 bound to cofactors and donor substrates.Luigi SciettiAntonella ChiapparinoFrancesca De GiorgiMarco FumagalliLela KhoriauliSolomon NergadzeShibom BasuVincent OliericLucia CuccaBlerida BanushiAntonella ProfumoElena GiulottoPaul GissenFederico FornerisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luigi Scietti Antonella Chiapparino Francesca De Giorgi Marco Fumagalli Lela Khoriauli Solomon Nergadze Shibom Basu Vincent Olieric Lucia Cucca Blerida Banushi Antonella Profumo Elena Giulotto Paul Gissen Federico Forneris Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
description	Lysyl hydroxylase 3 (LH3) catalyzes collagen lysine hydroxylation and their subsequent O-linked glycosylation. Here the authors provide mechanistic insights into the lysyl hydroxylase and glycosyltransferase activities of LH3 by determining the crystal structures of full-length human LH3 bound to cofactors and donor substrates.
format	article
author	Luigi Scietti Antonella Chiapparino Francesca De Giorgi Marco Fumagalli Lela Khoriauli Solomon Nergadze Shibom Basu Vincent Olieric Lucia Cucca Blerida Banushi Antonella Profumo Elena Giulotto Paul Gissen Federico Forneris
author_facet	Luigi Scietti Antonella Chiapparino Francesca De Giorgi Marco Fumagalli Lela Khoriauli Solomon Nergadze Shibom Basu Vincent Olieric Lucia Cucca Blerida Banushi Antonella Profumo Elena Giulotto Paul Gissen Federico Forneris
author_sort	Luigi Scietti
title	Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
title_short	Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
title_full	Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
title_fullStr	Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
title_full_unstemmed	Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
title_sort	molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase lh3
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9671310693c340349b00e760061a12e1
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_version_	1718380686500429824

Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3

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