Multiple autoimmunity and epitope spreading in monozygotic twins

We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibo...

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Autores principales:	Esperanza Avalos-Díaz, Elena Pérez-Pérez, Julio Granados, Deyanira Pacheco-Tovar, Juan-José Bollain-y-Goytia-de-la-Rosa, Rafael Herrera-Esparza
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Autoimmunity Autoimmune diseases Vitiligo Thyroiditis Multiple autoimmunity Epitope spreading Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/96716d78d7b847b79ee3bf6617c2d4d0
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spelling	oai:doaj.org-article:96716d78d7b847b79ee3bf6617c2d4d02021-11-14T04:35:14ZMultiple autoimmunity and epitope spreading in monozygotic twins2589-909010.1016/j.jtauto.2021.100132https://doaj.org/article/96716d78d7b847b79ee3bf6617c2d4d02021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589909021000526https://doaj.org/toc/2589-9090We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB104-DQB103:02 and HLA-DRB103-DQB10201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.Esperanza Avalos-DíazElena Pérez-PérezJulio GranadosDeyanira Pacheco-TovarJuan-José Bollain-y-Goytia-de-la-RosaRafael Herrera-EsparzaElsevierarticleAutoimmunityAutoimmune diseasesVitiligoThyroiditisMultiple autoimmunityEpitope spreadingImmunologic diseases. AllergyRC581-607ENJournal of Translational Autoimmunity, Vol 4, Iss , Pp 100132- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Autoimmunity Autoimmune diseases Vitiligo Thyroiditis Multiple autoimmunity Epitope spreading Immunologic diseases. Allergy RC581-607
spellingShingle	Autoimmunity Autoimmune diseases Vitiligo Thyroiditis Multiple autoimmunity Epitope spreading Immunologic diseases. Allergy RC581-607 Esperanza Avalos-Díaz Elena Pérez-Pérez Julio Granados Deyanira Pacheco-Tovar Juan-José Bollain-y-Goytia-de-la-Rosa Rafael Herrera-Esparza Multiple autoimmunity and epitope spreading in monozygotic twins
description	We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB104-DQB103:02 and HLA-DRB103-DQB10201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.
format	article
author	Esperanza Avalos-Díaz Elena Pérez-Pérez Julio Granados Deyanira Pacheco-Tovar Juan-José Bollain-y-Goytia-de-la-Rosa Rafael Herrera-Esparza
author_facet	Esperanza Avalos-Díaz Elena Pérez-Pérez Julio Granados Deyanira Pacheco-Tovar Juan-José Bollain-y-Goytia-de-la-Rosa Rafael Herrera-Esparza
author_sort	Esperanza Avalos-Díaz
title	Multiple autoimmunity and epitope spreading in monozygotic twins
title_short	Multiple autoimmunity and epitope spreading in monozygotic twins
title_full	Multiple autoimmunity and epitope spreading in monozygotic twins
title_fullStr	Multiple autoimmunity and epitope spreading in monozygotic twins
title_full_unstemmed	Multiple autoimmunity and epitope spreading in monozygotic twins
title_sort	multiple autoimmunity and epitope spreading in monozygotic twins
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/96716d78d7b847b79ee3bf6617c2d4d0
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_version_	1718429910733684736

Multiple autoimmunity and epitope spreading in monozygotic twins

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