Rate and Predictors of Mortality Among Adults on Antiretroviral Therapy at Debre Markos Referral Hospital, North West Ethiopia

Haddis Birhanu,1 Atsede Alle,2 Molla Yigzaw Birhanu2 1Debre Markos Referral Hospital, Debre Markos, Ethiopia; 2Department of Public Health, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Molla Yigzaw Birhanu P. O. Box 269 Email mollayigzaw33@gmail.comBackg...

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Autores principales:	Birhanu H, Alle A, Birhanu MY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hiv art mortality predictors of mortality debre markos ethiopia. Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/967346699bd94ab3a243c70233ccaf64
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spelling	oai:doaj.org-article:967346699bd94ab3a243c70233ccaf642021-12-02T14:32:47ZRate and Predictors of Mortality Among Adults on Antiretroviral Therapy at Debre Markos Referral Hospital, North West Ethiopia1179-1373https://doaj.org/article/967346699bd94ab3a243c70233ccaf642021-03-01T00:00:00Zhttps://www.dovepress.com/rate-and-predictors-of-mortality-among-adults-on-antiretroviral-therap-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Haddis Birhanu,1 Atsede Alle,2 Molla Yigzaw Birhanu2 1Debre Markos Referral Hospital, Debre Markos, Ethiopia; 2Department of Public Health, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Molla Yigzaw Birhanu P. O. Box 269 Email mollayigzaw33@gmail.comBackground: Human immunodeficiency virus/Acquired immunodeficiency syndrome is a chronic communicable disease with devastating global socio-economic, and political impacts commonly affecting the young and early adult populations. Ethiopia is doing well in controlling HIV/AIDS epidemic infection among African countries. This study set out to determine the mortality rate and its predictors among adults on antiretroviral therapy at Debre Markos Referral Hospital, northwest Ethiopia.Methods: A hospital-based retrospective follow-up study was conducted from February to March 2018. A computer-generated simple random sample selected 480 cards of patients on antiretroviral therapy who were enrolled between February 2010 to January 2018. Epi-data Version 4.2 software was used for data entry and SPSS Version 25 for management and analysis. An adjusted hazard rate with a 95% confidence interval was used to identify significant predictors of mortality.Results: The mortality rate was about 3.9 per 100 person-years. Cotrimoxazole prophylactic therapy (AHR: 2.99; 95% CI: 1.58, 5.70), being single (AHR: 2.37: 95% CI: 1.15, 4.87), non-disclosed status (AHR: 7.77; 95% CI: 3.76, 16.06), anemia (AHR: 2.16; 95% CI: 1.14, 4.09), bedridden (AHR: 6.11; 95% CI: 2.42, 15.41) or ambulatory (AHR: 2.16; 95%: 1.04, 4.51), presence of opportunistic infections (OIs) (AHR: 5.02; 95% CI: 1.70, 14.83) and tuberculosis (TB) co-infection (AHR: 5.57; 95% CI: 2.23, 13.88) were the significant predictors.Conclusion and Recommendation: This study had a high mortality rate. Being single, bedridden, TB coinfection, anemia, and cotrimoxazole prophylaxis were the predictors of mortality. Therefore, psychological support and close follow-up for single, non-disclosed, non-adherent patients and early detection and treatment of anemia, tuberculosis, and OIs to reduce mortality is recommended.Keywords: HIV, ART, mortality, predictors of mortality, Debre Markos, EthiopiaBirhanu HAlle ABirhanu MYDove Medical Pressarticlehivartmortalitypredictors of mortalitydebre markosethiopia.Immunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 251-259 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hiv art mortality predictors of mortality debre markos ethiopia. Immunologic diseases. Allergy RC581-607
spellingShingle	hiv art mortality predictors of mortality debre markos ethiopia. Immunologic diseases. Allergy RC581-607 Birhanu H Alle A Birhanu MY Rate and Predictors of Mortality Among Adults on Antiretroviral Therapy at Debre Markos Referral Hospital, North West Ethiopia
description	Haddis Birhanu,1 Atsede Alle,2 Molla Yigzaw Birhanu2 1Debre Markos Referral Hospital, Debre Markos, Ethiopia; 2Department of Public Health, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Molla Yigzaw Birhanu P. O. Box 269 Email mollayigzaw33@gmail.comBackground: Human immunodeficiency virus/Acquired immunodeficiency syndrome is a chronic communicable disease with devastating global socio-economic, and political impacts commonly affecting the young and early adult populations. Ethiopia is doing well in controlling HIV/AIDS epidemic infection among African countries. This study set out to determine the mortality rate and its predictors among adults on antiretroviral therapy at Debre Markos Referral Hospital, northwest Ethiopia.Methods: A hospital-based retrospective follow-up study was conducted from February to March 2018. A computer-generated simple random sample selected 480 cards of patients on antiretroviral therapy who were enrolled between February 2010 to January 2018. Epi-data Version 4.2 software was used for data entry and SPSS Version 25 for management and analysis. An adjusted hazard rate with a 95% confidence interval was used to identify significant predictors of mortality.Results: The mortality rate was about 3.9 per 100 person-years. Cotrimoxazole prophylactic therapy (AHR: 2.99; 95% CI: 1.58, 5.70), being single (AHR: 2.37: 95% CI: 1.15, 4.87), non-disclosed status (AHR: 7.77; 95% CI: 3.76, 16.06), anemia (AHR: 2.16; 95% CI: 1.14, 4.09), bedridden (AHR: 6.11; 95% CI: 2.42, 15.41) or ambulatory (AHR: 2.16; 95%: 1.04, 4.51), presence of opportunistic infections (OIs) (AHR: 5.02; 95% CI: 1.70, 14.83) and tuberculosis (TB) co-infection (AHR: 5.57; 95% CI: 2.23, 13.88) were the significant predictors.Conclusion and Recommendation: This study had a high mortality rate. Being single, bedridden, TB coinfection, anemia, and cotrimoxazole prophylaxis were the predictors of mortality. Therefore, psychological support and close follow-up for single, non-disclosed, non-adherent patients and early detection and treatment of anemia, tuberculosis, and OIs to reduce mortality is recommended.Keywords: HIV, ART, mortality, predictors of mortality, Debre Markos, Ethiopia
format	article
author	Birhanu H Alle A Birhanu MY
author_facet	Birhanu H Alle A Birhanu MY
author_sort	Birhanu H
title	Rate and Predictors of Mortality Among Adults on Antiretroviral Therapy at Debre Markos Referral Hospital, North West Ethiopia
title_short	Rate and Predictors of Mortality Among Adults on Antiretroviral Therapy at Debre Markos Referral Hospital, North West Ethiopia
title_full	Rate and Predictors of Mortality Among Adults on Antiretroviral Therapy at Debre Markos Referral Hospital, North West Ethiopia
title_fullStr	Rate and Predictors of Mortality Among Adults on Antiretroviral Therapy at Debre Markos Referral Hospital, North West Ethiopia
title_full_unstemmed	Rate and Predictors of Mortality Among Adults on Antiretroviral Therapy at Debre Markos Referral Hospital, North West Ethiopia
title_sort	rate and predictors of mortality among adults on antiretroviral therapy at debre markos referral hospital, north west ethiopia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/967346699bd94ab3a243c70233ccaf64
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_version_	1718391207270285312

Rate and Predictors of Mortality Among Adults on Antiretroviral Therapy at Debre Markos Referral Hospital, North West Ethiopia

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